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J Endod：非甾体抗炎药物作为下牙槽神经阻滞麻醉的术前口服药对治疗不可逆牙髓炎的效果

2018-06-08 lishiting MedSci原创

IANBNSAID
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下牙槽神经阻滞麻醉(IANB)的成功是治疗下颌不可逆牙髓炎的必要条件。这篇系统性的文献回顾的目的是为了评估非甾体抗炎药物(NSAIDs)作为IANB的术前口服药物对治疗不可逆牙髓炎的效果。

下牙槽神经阻滞麻醉(IANB)的成功是治疗下颌不可逆牙髓炎的必要条件。这篇系统性的文献回顾的目的是为了评估非甾体抗炎药物(NSAIDs)作为IANB的术前口服药物对治疗不可逆牙髓炎的效果。研究通过3个数据库搜索鉴定2017年以前的临床随机试验(RCTs)。使用修正循证医学风险偏倚工具对所搜索到的RCTs进行评估。药物的最初有效结果为IANB麻醉的成功率。通过随机效果模型进行Meta分析评估(risk ratio [RR] with 95% confidence intervals [CIs])，通过漏斗图分析评估出版文章的倾向性。通过试验序贯分析评估随机误差，并通过推荐，评估，开发和评估方法的分级来鉴定证据质量。结果显示，研究共筛选共13项RCTs (N = 1034)。8篇研究偏向风险较低。对高质量的RCTs统计学分析显示，与安慰剂相比，任何NSAID都可以显著增加IANBs的麻醉成功率(RR = 1.92； 95% CI， 1.55-2.38)。亚组的分析显示，布洛芬、双氯芬酸和酮咯酸也具有相似的有效结果(RR = 1.83 [95% CI， 1.43-2.35]， RR = 2.

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    2018-10-02 gdsun

    #口服药#

    0

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    2018-12-03 jxrzshh

    #牙髓#

    0

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    2018-06-10 ms8888626721583891

    #非甾体抗炎药#

    0

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    2018-06-10 xinmeili

    #抗炎药#

    0

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    2018-06-10 hb2011ye

    #牙髓炎#

    0

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    2018-06-08 哈哈869

    学了

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