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JAMA Psychiatry:陆林教授找到消除烟瘾记忆的新方法

2017-02-07 MedSci MedSci原创

<!--ewebeditor:page title=""--> 尼古丁依赖等病理性记忆相关精神心理问题无长期有效治疗方法,成为医学与社会难题。近日,<span style=""><span style="padding: 0px; margin: 0px; list-style: none; text-indent: 28px;">北京大学第六医院院长,北京大学精神卫生研究所所长,</span></span><span style="">陆林课题组一开创性研究成果为难以戒烟的人群带来福音。</span><br><br>陆林教授(北京大学IDG/麦戈文脑研究院和北京大学-清华大学生命科学联合中心的PI)课题组题为“应用普萘洛尔特异性抑制激活的尼古丁相关记忆对尼古丁心理渴求的影响”的研究论文成果见于2月1日的JAMA Psychiatry(《美国医学会杂志·精神病学》)杂志。<br><br>该研究成功实现了从动物研究到临床试验的成果转化,消除尼古丁依赖者的成瘾记忆、降低心理渴求。北京大学中国药物依赖性研究所薛言学副研究员和北京大学第六医院邓佳慧博士为该论文的共同第一作者,陆林为通讯作者。

尼古丁依赖等病理性记忆相关精神心理问题无长期有效治疗方法,成为医学与社会难题。近日,北京大学第六医院院长,北京大学精神卫生研究所所长,陆林课题组一开创性研究成果为难以戒烟的人群带来福音。

陆林教授(北京大学IDG/麦戈文脑研究院和北京大学-清华大学生命科学联合中心的PI)课题组题为“应用普萘洛尔特异性抑制激活的尼古丁相关记忆对尼古丁心理渴求的影响”的研究论文成果见于2月1日的JAMA Psychiatry(《美国医学会杂志·精神病学》)杂志。

该研究成功实现了从动物研究到临床试验的成果转化,消除尼古丁依赖者的成瘾记忆、降低心理渴求。北京大学中国药物依赖性研究所薛言学副研究员和北京大学第六医院邓佳慧博士为该论文的共同第一作者,陆林为通讯作者。

陆林介绍,烟草成瘾和依赖的本质是尼古丁依赖,是一种慢性高复发性疾病。尼古丁会导致大脑的神经通路发生可塑性改变,形成强烈持久的尼古丁成瘾记忆,使尼古丁依赖者持续存在吸烟欲望,这种欲望会削弱甚至摧毁戒烟的决心。因此,消除尼古丁依赖者的病理性成瘾记忆、降低心理渴求是临床戒烟成功的关键。

据悉,该研究成功实现了从动物研究到临床试验的成果转化,首先在动物尼古丁成瘾记忆模型中发现,采用小剂量尼古丁作为非条件性刺激唤起成瘾记忆后,再巩固时间窗内给予普萘洛尔可以有效消除动物的所有的尼古丁成瘾记忆。在吸烟成瘾人群中进一步研究发现,给予非条件性刺激(是指人吸烟后进入机体的尼古丁)后,在再巩固时间窗内口服普萘洛尔可以消除吸烟相关的记忆,降低多种吸烟相关线索诱发的心理渴求。

据中国疾病预防控制中心发布的《2015中国成人烟草调查报告》显示,我国15岁及以上人群吸烟率为27.7%,其中男性吸烟率为52.1%。吸烟者总数在2010年至2015年的五年时间里增加了1500万,已高达3.16亿。

陆林课题组在前期系列研究的基础上深入探索所取得的重要成果。陆林课题组于2012年和2015年分别在《科学》和《自然通讯》杂志发表论文,先后提出条件性线索记忆唤起和非条件性线索记忆唤起——消退心理学范式,发现记忆操纵范式可消除成瘾动物和成瘾者的成瘾记忆,降低其对于成瘾性药物的心理渴求及复吸的风险。这些研究成果也相继被国际同行在其他成瘾动物模型和成瘾人群中重复和验证。


原始出处:

Xue YX, Deng JH, Chen YY, Zhang LB, Wu P, Huang GD, Luo YX, Bao YP, Wang YM, Shaham Y, Shi J, Lu L. Effect of Selective Inhibition of Reactivated Nicotine-Associated Memories With Propranolol on Nicotine Craving. JAMA Psychiatry. 2017 Feb 1. doi: 10.1001/jamapsychiatry.2016.3907.

关于陆林:
陆林,教授

陆林,19669月生,男,医学博士,教授,博士生导师,北京大学第六医院院长,北京大学精神卫生研究所所长,国家自然科学杰出青年基金获得者,教育部***奖励计划特聘教授,国家自然科学基金委创新群体负责人.

研究论文多次发表在包括 Science, Nature Neuroscience,Trends in Neuroscience, American Journal of PsychiatryBiological Psychiatry Journal of Neuroscience等多个著名的国际期刊上,被国际同行多次引用,在精神病学以及药物依赖领域产生了重要影响。在国际性SCI期刊上发表学术论文150余篇,有十多篇文章被SCI期刊引用率超过100次,总引用率超过5000多次。主编(译)或参编论著15部,其中英文论著3部。

承担国家自然科学基金重点项目,973课题,863项目和重大科学计划项目等二十余项。担任美国神经免疫药理学会Councillor、中国药物依赖专业委员会主任委员、中国神经科学会精神病专业委员会常委和中国药理学会神经药理专业委员会委员、中国医院管理学会精神病院专业委员会委员和中国卫生经济学会医院经济专业委员会委员等。同时担任《中国药物依赖性杂志》主编、国际SCI杂志Drug AlcoholDepend副主编,Int JNeuropsychopharmacol, AddictionPlos One编辑及Int J Ment Health Addiction Am J Drug Alcohol Abuse编委,以及Science, Nat Med, Nat Neurosci,J Neurosci, Biol Psychiatry, Neuropsychopharmacology等四十余种国际杂志审稿人

研究兴趣:

神经精神疾病(如物质成瘾、抑郁症等)已成为二十一世纪危害人类健康的最主要疾病之一。陆林实验室研究抑郁症和药物依赖的神经生物学和临床治疗学。采用动物研究(大鼠及小鼠)及人体研究(抑郁症患者,药物成瘾者)相结合的模式,综合运用分子生物学、药理学、电生理、分子遗传学、心理学及神经影像学手段,探索 (1)抑郁症和药物依赖发病后的脑内突触可塑性改变;(2)病理性记忆动态变化的分子生物学机制;(3)抑郁症和药物依赖患者的心理、认知的变化规律及其干预手段。

代表性科研论文:

1.Xue YX, Luo YX, Wu P, Shi HS, Xue LF, Chen C, Zhu WL, Ding ZB, Bao YP, Shi J, Epstein DH, Shaham Y, Lu L.*(2012) A memory retrieval-extinction procedure to prevent drug craving and relapse. Science, 336(6078):241-5.

2.Zhang XL, Shi J, Zhao LY, Sun LL, Wang J, Wang GB, Epstein DH, Lu L.* (2011) Effects of Stress on Decision-Making Deficits in Formerly Heroin-Dependent Patients After Different Durations of Abstinence. Am J Psychiatry. , 168(6):610-6.

3.Li YQ, Xue YX, He YY, Li FQ, Xue LF, Xu CM, Sacktor TC, Shaham Y, Lu L.*(2011) Inhibition of PKMzeta in nucleus accumbens core abolishes long-term drug reward memory. J Neurosci., 31(14):5436-46.

4.Li FQ, Xue YX, Wang JS, Fang Q, Li YQ, Zhu WL, He YY, Liu JF, Xue LF, Shaham Y, Lu L.*(2010) Basolateral amygdala cdk5 activity mediates consolidation and reconsolidation of memories for cocaine cues. J Neurosci, 30:10351-9.

5.Wang X, Luo YX, He YY, Li FQ, Shi HS, Xue LF, Xue YX, Lu L.* (2010 Sep 22) Nucleus accumbens core mammalian target of rapamycin signaling pathway is critical for cue-induced reinstatement of cocaine seeking in rats. J Neurosci, 30(38):12632-41

6.Li SX, Shi J, Epstein DH, Wang X, Zhang XL, Bao YP, Zhang D, Zhang XY, Kosten TR, Lu L.* (2009) Circadian Alteration in Neurobiology During 30 Days of Abstinence in Heroin Users. Biol Psychiatry, 65(10):905-12

7.Wang XY, Zhao M, Ghitza UE, Li YQ, Lu L.* (2008)  Stress impairs reconsolidation of drug memory via glucocorticoid receptors in the basolateral amygdala. J Neurosci, 28:5602-10.

8.Lu L., Hope BT, Dempsey J, Liu SY, Bossert JM, Shaham Y*.(2005) Central amygdala ERK signaling pathway is critical to incubation of cocaine craving. Nat Neurosci., 8:212-9.

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    2017-08-09 kord1982
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    2017-02-09 天涯183

    最新研究进展

    0

  4. 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    2017-02-08 天涯183

    说的非常好

    0

  5. 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level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7f142008051, createdName=望平真人, createdTime=Tue Feb 07 19:31:04 CST 2017, time=2017-02-07, status=1, ipAttribution=)]
    2017-02-08 卡圣

    长见识了

    0

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createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K3ycVveJIVibcQDzZtvWnelEp0f6IZo3gsgiaCuRIEMlGEF570q8Dic6vDITW6icqBf0pKo8Kfo8D5om/0, createdBy=4d8650145, createdName=bettysun, createdTime=Tue Feb 07 19:57:49 CST 2017, time=2017-02-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=174809, encodeId=ab931e4809f1, content=尼古丁依赖等病理性记忆相关精神心理问题无长期有效治疗方法,成为医学与社会难题, beContent=null, objectType=article, channel=null, level=null, likeNumber=140, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuF63NQckT5BOaic1el7cRelbpr859YXtZQHQSaWnqZCRPOZzDBcjsBNx7AFefLHh1UvMPS4kPP0BG/0, createdBy=47831990981, createdName=1e1a50a1m36(暂无匿称), createdTime=Tue Feb 07 19:57:17 CST 2017, time=2017-02-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=174801, encodeId=d4cc1e480193, content=戒烟有了新方法, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7f142008051, createdName=望平真人, createdTime=Tue Feb 07 19:31:04 CST 2017, time=2017-02-07, status=1, ipAttribution=)]
    2017-02-08 只玩辅助

    挺好的,学习了

    0

  7. 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level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7f142008051, createdName=望平真人, createdTime=Tue Feb 07 19:31:04 CST 2017, time=2017-02-07, status=1, ipAttribution=)]
    2017-02-07 墨尔

    这个真的高大上

    0

  8. 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level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7f142008051, createdName=望平真人, createdTime=Tue Feb 07 19:31:04 CST 2017, time=2017-02-07, status=1, ipAttribution=)]
    2017-02-07 bettysun

    烟瘾和雾霾一起消散!

    0

  9. 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level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7f142008051, createdName=望平真人, createdTime=Tue Feb 07 19:31:04 CST 2017, time=2017-02-07, status=1, ipAttribution=)]
    2017-02-07 1e1a50a1m36(暂无匿称)

    尼古丁依赖等病理性记忆相关精神心理问题无长期有效治疗方法,成为医学与社会难题

    0

  10. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=75381686177, createdName=只玩辅助, createdTime=Wed Feb 08 00:02:33 CST 2017, time=2017-02-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=174826, encodeId=e2881e4826ff, content=这个真的高大上, beContent=null, objectType=article, channel=null, level=null, likeNumber=159, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ee471989203, createdName=墨尔, createdTime=Tue Feb 07 21:27:37 CST 2017, time=2017-02-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=174810, encodeId=d9e21e48100b, content=烟瘾和雾霾一起消散!, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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    2017-02-07 望平真人

    戒烟有了新方法

    0

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