Neurology：动脉瘤性蛛网膜下腔出血后癫痫相关的长期死亡分析！

2017-06-15 xing.T MedSci原创

由此可见，在SIA-SAH后的12个月幸存者中在长期随访中伴发癫痫与死亡风险增加相关。SIA-SAH幸存者需要长期精心随访，包括伴发癫痫的识别和有效的治疗以防止可以避免的死亡。

近日，神经病学领域权威取杂志Neurology上发表了一篇研究文章，研究人员旨在阐明囊形颅内动脉瘤导致的蛛网膜下腔出血（SIA-SAH）12个月幸存者癫痫相关的死亡原因以及随后的过量长期死亡率。

研究人员通过库奥皮奥SIA数据库纳入了所有的入住库奥皮奥大学医院的SIA-SAH患者。该研究队列由在1995年至2007年期间入院的779例患者组成，并且这些患者在SIA-SAH后幸存了12个月。研究人员从芬兰国家登记中心获得1994年至2014年期间这些患者所使用的补偿抗癫痫药物和死亡原因（ICD-10）。

该研究共有779例12个月存活者，随访至其死亡（n=197）或2014年12月31日，SIA-SAH后平均12年。SIA-SAH后有121例（15%）患者被确诊为癫痫，34/121（28%）死于随访结束时，7/34例（21%）患者以癫痫作为死亡的直接原因。SIA-SAH后12个月仍存活的779例患者中，癫痫是死亡的独立危险因素（风险比为1.8，95%可信区间为1.1-3）。

由此可见，在SIA-SAH后的12个月幸存者中在长期随访中伴发癫痫与死亡风险增加相关。SIA-SAH幸存者需要长期精心随访，包括伴发癫痫的识别和有效的治疗以防止可以避免的死亡。

原始出处：

Jukka Huttunen,et al. Epilepsy-associated long-term mortality after aneurysmal subarachnoid hemorrhage. Neurology. 2017.http://dx.doi.org/10.1212/WNL.0000000000004113

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#插入话题

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2018-04-16 aliceclz

#蛛网膜#

38 0
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2018-02-11 yinhl1978

#Neurol#

34 0
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2017-06-17 紫砂壶

#动脉瘤性蛛网膜下腔出血#

32 0
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2017-06-16 dachengl

数据库+良好的随访的贡献

73 0
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2017-06-16 meiliwuxian

学习一下

69 0
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2017-06-16 1e10c84am36(暂无匿称)

好文章，值得拜读，受益

68 0
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2017-06-15 虈亣靌

学习了，受益匪浅。

51 0

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