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SCI REP:晚发性循环衰竭和持续气道正压是早产儿视网膜病变治疗需要的有用预测因素:一个9年回顾性分析

2017-06-20 MedSci MedSci原创

我们确定了TR-ROP的有用预测因子。我们的研究结果表明,具有LCC病史和CPAP长期呼吸支持的早产儿具有发展TR-ROP的高风险。

如果可以预测需要治疗的ROP(TR-ROP),则可以预防由早产儿视网膜病变引起的视力损失(ROP)。在这项回顾性研究中,包括418名胎龄≤32周(GA)和/或≤1500克出生体重的婴儿,在这项研究中尝试识别有用的预测因子。研究人员还检查了与现有预测模型ROPScore和CHOP模型相比的重要预测因子的效率。多变量逻辑回归分析支持以下因素对于预测所有婴儿中的ROP以及婴儿带有的任何形式的ROP:GA(优势比[OR],0.47和0.48),晚发性循环衰竭(LCC)(OR, 2.76和2.44),以及在经期后35周(OR,3.78和4.50)使用持续气道正压(CPAP)。受试者工作特征曲线下的区域比较表明,所有婴儿中的ROP和任何形式的婴儿ROP(P = 0.007和0.02)和LCC,CPAP和ROP评分的组合优于ROP评分,并且预测所有婴儿和任何形式的婴儿ROP时,LCC,CPAP和CHOP模型的组合也优于CHOP模型(P = 0.01和0.02)。表明,具有LCC史和长期CPAP支持的婴儿的TR-ROP发病率很高。

结论:研究人员 确定了TR-ROP的有用预测因子。研究结果表明,具有LCC病史和CPAP长期呼吸支持的早产儿具有发展TR-ROP的高风险。

原文出处:

Kanako Fujikawa,Koh-Hei Sonoda,et al.Late-onset Circulatory Collapse and Continuous Positive Airway Pressure are Useful Predictors of Treatment-requiring Retinopathy of Prematurity: A 9-year Retrospective Analysis.[J]Scientific Reports 7, Article number:3904(2017), doi:10.1038/s41598-017-04269-5

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    2017-06-22 zutt
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