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J Am Geriatr Soc:英国研究称,≥80岁老人血压降至135 mmHg以下有害

2017-09-06 文韬 中国循环杂志

英国近期一项观察近8万人随访4年的研究发现,对于≥80岁的老年人,收缩压在于135~154 mmHg者的全因死亡率最低,而治疗后血压水平<135 mmHg者全因死亡率则增加25%。

英国近期一项观察近8万人随访4年的研究发现,对于≥80岁的老年人,收缩压在于135~154 mmHg者的全因死亡率最低,而治疗后血压水平<135 mmHg者全因死亡率则增加25%。

研究估计,每将13例患者的血压降至<135 mmHg,就多增加1例死亡事件。

研究还发现,治疗后血压水平>155 mmHg者的死亡情况与<135 mmHg者是相似的。

作者称,高龄老年高血压患者的血压并非降得越低越好。有必要进一步研究确定老年患者的理想降压目标。


不同血压水平的高龄老年患者死亡风险

总体而言,心肌梗死风险与血压水平呈线性相关,随治疗后血压水平增加而进行性增加。


血压与心肌梗死风险呈线性相关

卒中和心力衰竭风险在治疗后血压水平仍>155 mmHg是增加的。治疗后血压水平<125 mmHg的患者的心力衰竭风险也增加。


血压>155 mmHg后卒中风险增加

但是,治疗后血压水平与脆性骨折并无相关性,无证据表明血压增高可增加骨折风险。

研究入选了英国初级保健实践数据库中79 376例至少处方应用1种降压药物、3年间至少3次测量血压、年龄≥80岁的、基线无痴呆症、癌症、冠心病、卒中、心力衰竭(HF)及终末期肾功能衰竭的老年高血压患者,根据治疗后血压水平对受试者进行分组分析(最低组为<125 mmHg,最高组为>185 mmHg,中间以10 mmHg为增量进行分组)。患者的平均年龄为82.1岁,女性占69.5%。

原始出处:Delgado J, Masoli JAH, Bowman K, et al. Outcomes of treated hypertension at age 80 and older: cohort analysis of 79,376 individuals. J Am Geriatr Soc 2017;65:995-1003.

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    2017-09-27 1e207054m17(暂无匿称)

    对于老年人降压程度.又有了新证据.谢谢

    0

  2. 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beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Thu Sep 07 08:13:45 CST 2017, time=2017-09-07, status=1, ipAttribution=)]
    2017-09-13 189****7206

    学习了受益匪浅

    0

  4. 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beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Thu Sep 07 08:13:45 CST 2017, time=2017-09-07, status=1, ipAttribution=)]
    2017-09-11 guangyi1980

    学习了

    0

  5. 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beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Thu Sep 07 08:13:45 CST 2017, time=2017-09-07, status=1, ipAttribution=)]
    2017-09-10 184****9840

    学习了受益匪浅

    0

  6. 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createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLPeNmuNF9ibgMfMOAs7Iic5MpiaU8RLmRH67xCKuk5wzfhb7G4ib7ia6z9lrnsTicj1nAUfEOMecZDtvvu/0, createdBy=d7f91939785, createdName=186****0580(小山羊), createdTime=Thu Sep 07 09:37:32 CST 2017, time=2017-09-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=241389, encodeId=fe0524138939, content=英国近期一项观察近8万人随访4年的研究发现.对于≥80岁的老年人.收缩压在于135~154 mmHg者的全因死亡率最低.而治疗后血压水平<135 mmHg者全因死亡率则增加25%. , beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3wrgsNyr5lh6N2MY5xSnbvo4g5sRlc3MZoDdWpMeSdozUCPNhA96wndwQe3X5Z5oYMNxVUdOib63nw/0, createdBy=d8d11998754, createdName=Julie W, createdTime=Thu Sep 07 08:40:31 CST 2017, time=2017-09-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=241368, encodeId=1c7e24136836, content=学习了很有用不错, 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    2017-09-08 yfjms

    学习了

    0

  7. 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createdTime=Fri Sep 08 07:06:35 CST 2017, time=2017-09-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=241509, encodeId=f0f424150959, content=很好.学习了.很有帮助., beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Thu Sep 07 19:39:27 CST 2017, time=2017-09-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=241414, encodeId=8fdb24141436, content=学习了谢谢了, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLPeNmuNF9ibgMfMOAs7Iic5MpiaU8RLmRH67xCKuk5wzfhb7G4ib7ia6z9lrnsTicj1nAUfEOMecZDtvvu/0, createdBy=d7f91939785, createdName=186****0580(小山羊), createdTime=Thu Sep 07 09:37:32 CST 2017, time=2017-09-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=241389, encodeId=fe0524138939, content=英国近期一项观察近8万人随访4年的研究发现.对于≥80岁的老年人.收缩压在于135~154 mmHg者的全因死亡率最低.而治疗后血压水平<135 mmHg者全因死亡率则增加25%. , beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3wrgsNyr5lh6N2MY5xSnbvo4g5sRlc3MZoDdWpMeSdozUCPNhA96wndwQe3X5Z5oYMNxVUdOib63nw/0, createdBy=d8d11998754, createdName=Julie W, createdTime=Thu Sep 07 08:40:31 CST 2017, time=2017-09-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=241368, encodeId=1c7e24136836, content=学习了很有用不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Thu Sep 07 08:13:45 CST 2017, time=2017-09-07, status=1, ipAttribution=)]
    2017-09-07 李东泽

    很好.学习了.很有帮助.

    0

  8. 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createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLPeNmuNF9ibgMfMOAs7Iic5MpiaU8RLmRH67xCKuk5wzfhb7G4ib7ia6z9lrnsTicj1nAUfEOMecZDtvvu/0, createdBy=d7f91939785, createdName=186****0580(小山羊), createdTime=Thu Sep 07 09:37:32 CST 2017, time=2017-09-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=241389, encodeId=fe0524138939, content=英国近期一项观察近8万人随访4年的研究发现.对于≥80岁的老年人.收缩压在于135~154 mmHg者的全因死亡率最低.而治疗后血压水平<135 mmHg者全因死亡率则增加25%. , beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3wrgsNyr5lh6N2MY5xSnbvo4g5sRlc3MZoDdWpMeSdozUCPNhA96wndwQe3X5Z5oYMNxVUdOib63nw/0, createdBy=d8d11998754, createdName=Julie W, createdTime=Thu Sep 07 08:40:31 CST 2017, time=2017-09-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=241368, encodeId=1c7e24136836, content=学习了很有用不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Thu Sep 07 08:13:45 CST 2017, time=2017-09-07, status=1, ipAttribution=)]
    2017-09-07 186****0580(小山羊)

    学习了谢谢了

    0

  9. 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beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Thu Sep 07 08:13:45 CST 2017, time=2017-09-07, status=1, ipAttribution=)]
    2017-09-07 Julie W

    英国近期一项观察近8万人随访4年的研究发现.对于≥80岁的老年人.收缩压在于135~154 mmHg者的全因死亡率最低.而治疗后血压水平<135 mmHg者全因死亡率则增加25%.

    0

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    2017-09-07 飛歌

    学习了很有用不错

    0

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