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Am J Cardiol:经皮主动脉瓣置入无心脑高风险

2012-03-03 MedSci MedSci原创

 意大利学者的一项研究表明,与外科主动脉瓣置换(SAVR)相比,经皮主动脉瓣置入(TAVI)与1年严重不良心脑血管事件(MACCE)高风险无相关性。论文于2012年2月23日在线发表于《美国心脏病学杂志》(Am J Cardiol)。   此项研究连续性纳入218例成功接受TAVI治疗和400例接受单独SAVR治疗的患者,并对其早期和中期转归进行了评估。主要终点为1年MACC

 意大利学者的一项研究表明,与外科主动脉瓣置换(SAVR)相比,经皮主动脉瓣置入(TAVI)与1年严重不良心脑血管事件(MACCE)高风险无相关性。论文于2012年2月23日在线发表于《美国心脏病学杂志》(Am J Cardiol)。

  此项研究连续性纳入218例成功接受TAVI治疗和400例接受单独SAVR治疗的患者,并对其早期和中期转归进行了评估。主要终点为1年MACCE发生率。

  结果显示,共有73例(11.8%)患者出现院内MACCE,SAVR组患者发生率高于TAVI组(P=0.022)。利用3种统计校正方法明确潜在混淆因素后,SAVR与MACCE风险升高始终相关;30天时相对危险度估计值为2.2~2.6,60天时为2.4~2.5,12个月时为 2.0~2.2。差异由SAVR组6和12个月时致死性出血和12个月时卒中校正风险升高引起;两组患者各时间点的死亡、卒中和心肌梗死风险均无差异。

  链接:

  Comparison of Complications and Outcomes to One Year of Transcatheter Aortic Valve Implantation Versus Surgical Aortic Valve Replacement in Patients With Severe Aortic Stenosis

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