Baidu
map

消化

订阅

MedSci主页 / 所有栏目 / 消化

AACR19：APX005M具有治疗转移性胰腺癌的前景

2019-04-02 不详 网络

APX005M转移性胰腺癌紫杉醇
关注

Apexigen制药公司在美国癌症研究协会（AACR）年度会议上报告了其实验性药物APX005M在联合方案中治疗转移性胰腺癌的早期阳性数据。APX005M是靶向CD40的单克隆抗体。在Ib/ II期研究中，未接受过治疗的转移性胰腺导管腺癌患者接受了APX005M、吉西他滨和紫杉醇组成的标准化疗，其余受试者接受了nivolumab单抗的治疗。

Apexigen制药公司在美国癌症研究协会（AACR）年度会议上报告了其实验性药物APX005M在联合方案中治疗转移性胰腺癌的早期阳性数据。APX005M是靶向CD40的单克隆抗体。在Ib/ II期研究中，未接受过治疗的转移性胰腺导管腺癌患者接受了APX005M、吉西他滨和紫杉醇组成的标准化疗，其余受试者接受了nivolumab单抗的治疗。

这项中期分析的结果显示，24名患者中有20名患者的肿瘤组织缩小。Apexigen首席医疗官奥维德·特里芬说：“一些患者在接受治疗一年后仍在接受治疗，鉴于大多数转移性胰腺癌患者在开始一线化疗后约5个月内有癌症进展的证据，能够看到有几位患者在这项试验中停留一年以上是令人兴奋的”。


原始出处：

http://www.firstwordpharma.com/node/1632530#axzz5jptFWRuj

本文系梅斯医学（MedSci）原创编译整理，转载需授权!

版权声明：
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料，版权均属于梅斯医学所有。非经授权，任何媒体、网站或个人不得转载，授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章，或“梅斯号”自媒体发布的文章，仅系出于传递更多信息之目的，本站仅负责审核内容合规，其内容不代表本站立场，本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系，我们将立即进行删除处理。
在此留言
评论区 (5)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=2033931, encodeId=2bb52033931c7, content=<a href='/topic/show?id=1fd42e02fd' target=_blank style='color:#2F92EE;'>#APX005M#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2702, encryptionId=1fd42e02fd, topicName=APX005M)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ce68183, createdName=xiongke010, createdTime=Sat Nov 30 15:00:00 CST 2019, time=2019-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1386484, encodeId=982113864848e, content=<a href='/topic/show?id=f08293399f9' target=_blank style='color:#2F92EE;'>#转移性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93399, encryptionId=f08293399f9, topicName=转移性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1ac22500003, createdName=1249842em09(暂无昵称), createdTime=Thu Apr 04 01:00:00 CST 2019, time=2019-04-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1390221, encodeId=520213902217d, content=<a href='/topic/show?id=8c36934354a' target=_blank style='color:#2F92EE;'>#转移性胰腺癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93435, encryptionId=8c36934354a, topicName=转移性胰腺癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a5002500055, createdName=124986d2m09暂无昵称, createdTime=Thu Apr 04 01:00:00 CST 2019, time=2019-04-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1400419, encodeId=81b61400419c4, content=<a href='/topic/show?id=e7c018e7af' target=_blank style='color:#2F92EE;'>#ACR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1877, encryptionId=e7c018e7af, topicName=ACR)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Thu Apr 04 01:00:00 CST 2019, time=2019-04-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1551990, encodeId=528a1551990d3, content=<a href='/topic/show?id=169c166430' target=_blank style='color:#2F92EE;'>#AACR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1664, encryptionId=169c166430, topicName=AACR)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6b2714248200, createdName=Luyuxie_14, createdTime=Thu Apr 04 01:00:00 CST 2019, time=2019-04-04, status=1, ipAttribution=)]
    2019-11-30 xiongke010

    #APX005M#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=2033931, encodeId=2bb52033931c7, content=<a href='/topic/show?id=1fd42e02fd' target=_blank style='color:#2F92EE;'>#APX005M#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2702, encryptionId=1fd42e02fd, topicName=APX005M)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ce68183, createdName=xiongke010, createdTime=Sat Nov 30 15:00:00 CST 2019, time=2019-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1386484, encodeId=982113864848e, content=<a href='/topic/show?id=f08293399f9' target=_blank style='color:#2F92EE;'>#转移性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93399, encryptionId=f08293399f9, topicName=转移性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1ac22500003, createdName=1249842em09(暂无昵称), createdTime=Thu Apr 04 01:00:00 CST 2019, time=2019-04-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1390221, encodeId=520213902217d, content=<a href='/topic/show?id=8c36934354a' target=_blank style='color:#2F92EE;'>#转移性胰腺癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93435, encryptionId=8c36934354a, topicName=转移性胰腺癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a5002500055, createdName=124986d2m09暂无昵称, createdTime=Thu Apr 04 01:00:00 CST 2019, time=2019-04-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1400419, encodeId=81b61400419c4, content=<a href='/topic/show?id=e7c018e7af' target=_blank style='color:#2F92EE;'>#ACR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1877, encryptionId=e7c018e7af, topicName=ACR)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Thu Apr 04 01:00:00 CST 2019, time=2019-04-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1551990, encodeId=528a1551990d3, content=<a href='/topic/show?id=169c166430' target=_blank style='color:#2F92EE;'>#AACR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1664, encryptionId=169c166430, topicName=AACR)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6b2714248200, createdName=Luyuxie_14, createdTime=Thu Apr 04 01:00:00 CST 2019, time=2019-04-04, status=1, ipAttribution=)]
    2019-04-04 1249842em09(暂无昵称)

    #转移性#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=2033931, encodeId=2bb52033931c7, content=<a href='/topic/show?id=1fd42e02fd' target=_blank style='color:#2F92EE;'>#APX005M#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2702, encryptionId=1fd42e02fd, topicName=APX005M)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ce68183, createdName=xiongke010, createdTime=Sat Nov 30 15:00:00 CST 2019, time=2019-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1386484, encodeId=982113864848e, content=<a href='/topic/show?id=f08293399f9' target=_blank style='color:#2F92EE;'>#转移性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93399, encryptionId=f08293399f9, topicName=转移性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1ac22500003, createdName=1249842em09(暂无昵称), createdTime=Thu Apr 04 01:00:00 CST 2019, time=2019-04-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1390221, encodeId=520213902217d, content=<a href='/topic/show?id=8c36934354a' target=_blank style='color:#2F92EE;'>#转移性胰腺癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93435, encryptionId=8c36934354a, topicName=转移性胰腺癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a5002500055, createdName=124986d2m09暂无昵称, createdTime=Thu Apr 04 01:00:00 CST 2019, time=2019-04-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1400419, encodeId=81b61400419c4, content=<a href='/topic/show?id=e7c018e7af' target=_blank style='color:#2F92EE;'>#ACR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1877, encryptionId=e7c018e7af, topicName=ACR)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Thu Apr 04 01:00:00 CST 2019, time=2019-04-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1551990, encodeId=528a1551990d3, content=<a href='/topic/show?id=169c166430' target=_blank style='color:#2F92EE;'>#AACR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1664, encryptionId=169c166430, topicName=AACR)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6b2714248200, createdName=Luyuxie_14, createdTime=Thu Apr 04 01:00:00 CST 2019, time=2019-04-04, status=1, ipAttribution=)]
    2019-04-04 124986d2m09暂无昵称

    #转移性胰腺癌#

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=2033931, encodeId=2bb52033931c7, content=<a href='/topic/show?id=1fd42e02fd' target=_blank style='color:#2F92EE;'>#APX005M#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2702, encryptionId=1fd42e02fd, topicName=APX005M)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ce68183, createdName=xiongke010, createdTime=Sat Nov 30 15:00:00 CST 2019, time=2019-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1386484, encodeId=982113864848e, content=<a href='/topic/show?id=f08293399f9' target=_blank style='color:#2F92EE;'>#转移性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93399, encryptionId=f08293399f9, topicName=转移性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1ac22500003, createdName=1249842em09(暂无昵称), createdTime=Thu Apr 04 01:00:00 CST 2019, time=2019-04-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1390221, encodeId=520213902217d, content=<a href='/topic/show?id=8c36934354a' target=_blank style='color:#2F92EE;'>#转移性胰腺癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93435, encryptionId=8c36934354a, topicName=转移性胰腺癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a5002500055, createdName=124986d2m09暂无昵称, createdTime=Thu Apr 04 01:00:00 CST 2019, time=2019-04-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1400419, encodeId=81b61400419c4, content=<a href='/topic/show?id=e7c018e7af' target=_blank style='color:#2F92EE;'>#ACR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1877, encryptionId=e7c018e7af, topicName=ACR)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Thu Apr 04 01:00:00 CST 2019, time=2019-04-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1551990, encodeId=528a1551990d3, content=<a href='/topic/show?id=169c166430' target=_blank style='color:#2F92EE;'>#AACR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1664, encryptionId=169c166430, topicName=AACR)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6b2714248200, createdName=Luyuxie_14, createdTime=Thu Apr 04 01:00:00 CST 2019, time=2019-04-04, status=1, ipAttribution=)]
    2019-04-04 heli0118

    #ACR#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=2033931, encodeId=2bb52033931c7, content=<a href='/topic/show?id=1fd42e02fd' target=_blank style='color:#2F92EE;'>#APX005M#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2702, encryptionId=1fd42e02fd, topicName=APX005M)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ce68183, createdName=xiongke010, createdTime=Sat Nov 30 15:00:00 CST 2019, time=2019-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1386484, encodeId=982113864848e, content=<a href='/topic/show?id=f08293399f9' target=_blank style='color:#2F92EE;'>#转移性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93399, encryptionId=f08293399f9, topicName=转移性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1ac22500003, createdName=1249842em09(暂无昵称), createdTime=Thu Apr 04 01:00:00 CST 2019, time=2019-04-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1390221, encodeId=520213902217d, content=<a href='/topic/show?id=8c36934354a' target=_blank style='color:#2F92EE;'>#转移性胰腺癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93435, encryptionId=8c36934354a, topicName=转移性胰腺癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a5002500055, createdName=124986d2m09暂无昵称, createdTime=Thu Apr 04 01:00:00 CST 2019, time=2019-04-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1400419, encodeId=81b61400419c4, content=<a href='/topic/show?id=e7c018e7af' target=_blank style='color:#2F92EE;'>#ACR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1877, encryptionId=e7c018e7af, topicName=ACR)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Thu Apr 04 01:00:00 CST 2019, time=2019-04-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1551990, encodeId=528a1551990d3, content=<a href='/topic/show?id=169c166430' target=_blank style='color:#2F92EE;'>#AACR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1664, encryptionId=169c166430, topicName=AACR)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6b2714248200, createdName=Luyuxie_14, createdTime=Thu Apr 04 01:00:00 CST 2019, time=2019-04-04, status=1, ipAttribution=)]
    2019-04-04 Luyuxie_14

    #AACR#

    0

Baidu
map
Baidu
map
Baidu
map