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Cell Biosci:糖尿病与阿尔茨海默病的因果关系评价及抗糖尿病药物的基因分析

2022-03-21 从医路漫漫 MedSci原创

阿尔茨海默病(AD)是最常见的进行性神经退行性疾病,在全球范围内发病率呈上升趋势。

背景:阿尔茨海默病(AD)是最常见的进行性神经退行性疾病,在全球范围内发病率呈上升趋势。根据阿尔茨海默病国际组织发布的《2018年世界阿尔茨海默病报告》,全球有超过5000万人患有痴呆症,阿尔茨海默病占所有痴呆症病例的60%-80%。随着疾病的加重,AD患者会表现出一系列的临床特征,包括进行性记忆丧失、认知功能逐渐受损、行为和个性改变。考虑到患者、家庭和社会负担的稳步增加,已经进行了可改变的危险因素筛查,以降低AD的风险。糖尿病,包括1型糖尿病(T1D)、2型糖尿病(T2D)和妊娠期糖尿病,是一种高血糖水平的慢性代谢性疾病,可损害血管和神经,并导致多种严重并发症。根据国际糖尿病联合会的数据,每11个成年人中就有1人患有糖尿病(4.25亿人),2017年全球卫生支出的12%用于糖尿病。

    最近,AD与几种慢性疾病的关系越来越受到关注,其中糖尿病因一系列致病关联而引起人们的极大兴趣。例如,在过去的几十年里,重要的流行病学证据表明,糖尿病患者患AD的风险增加了约53%。此外,与糖尿病相关的机制,如IR/PI3K/Akt信号转导功能障碍、炎症增加、氧化应激等,可能加速AD病理事件的发展。此外,越来越多的研究也在基因水平上支持AD和糖尿病之间的联系。先前的一项研究已经确定了395个SNPs共享AD和T2D的相同风险等位基因,这表明两种疾病之间存在共同的遗传病因风险因素。相应地,在这两种疾病之间密切联系的启发下,研究抗糖尿病药物治疗AD的研究大大增加。令人兴奋的是,初步研究表明,许多抗糖尿病药物,如利拉鲁肽、吡格列酮、利昔那肽、罗格列酮、胰岛素和exendin-4等对AD具有治疗作用,提示糖尿病和AD可能有共同的遗传病因危险因素,特别是为AD药物的开发提供了一条潜在的新途径。

目的:这些研究表明糖尿病与AD的风险密切相关,抗糖尿病药物在治疗AD方面也备受关注;然而,糖尿病与AD是否存在因果关系尚不清楚,抗糖尿病药物靶点对AD的影响仍有待进一步评估。孟德尔随机化使用遗传变异作为可修改风险因素的替代,以测试风险因素是否与感兴趣的结果因果相关,这可以将混杂因素的影响降至最低[15]。因此,本研究进行了两样本孟德尔随机化(2SMR)分析,以评估:i)糖尿病是否与AD风险的增加存在因果关系;ii)如果是,哪些与糖尿病相关的生理参数,如血糖、胰岛素和其他,与AD有关;iii)如何将糖尿病药物用作治疗AD的候选药物。

结果:首先,2SMR分析提供了遗传预测的1型糖尿病(T1D)与轻微增加的AD风险之间的关联(OR=1.04,95%CI=[1.01,1.06]),而2型糖尿病(T2D)与AD风险的关联更强(OR=1.34,95%CI=[1.05,1.70])。其次,进一步的2SMR分析显示糖尿病相关的生理参数如空腹血糖和总胆固醇水平可能在AD的发生发展中起不利作用。第三,我们获得了74种降糖药物,并确定了SNPs来替代降糖药物的靶点。2 SMR分析显示,ETFDH、GANC和MGAM三个靶基因的表达与AD的危险性增加有关,而CPE可能是AD的保护因素。此外,进一步的PPI网络发现GANC与MGAM相互作用,并进一步与与AD相关的强遗传位点CD33相互作用。

图1.2 T1D与AD风险之间因果关系的SMR分析。散布图。直线的斜率对应于使用四种不同方法中的每一种方法的因果估计。B漏斗图。竖线显示了两种不同方法中每一种方法的因果估计,使用的是将所有SNPs组合成一个工具。C森林地块。每个黑点表示使用Wald比率的每个SNP的MR估计,水平线表示95%的CI。

表1.2糖尿病和阿尔茨海默病之间因果关系的SMR估计

图2.2 T2D与AD风险之间因果关系的SMR分析。散布图。直线的斜率对应于使用四种不同方法中的每一种方法的因果估计。B漏斗图。竖线显示了两种不同方法中每一种方法的因果估计,使用的是将所有SNPs组合成一个工具。C森林地块。每个黑点表示使用Wald比率的每个SNP的MR估计,水平线表示95%的CI。

图3.2空腹血糖和总胆固醇水平与AD之间因果关系的SMR估计。A)空腹血糖和阿尔茨海默病的因果关系。B)总胆固醇水平和阿尔茨海默病的因果关系

图7基于识别的目标(CPE、ETFDH、GANC、MGAM)和AD易感基因的基于网络的分析。组合分数映射到边大小,结点度映射到节点大小和节点颜色

结论:总而言之,本研究提供了糖尿病和AD风险增加之间存在因果关系的证据,也为药物开发提供了有用的遗传线索。

原文出处:  Meng L,  Wang Z,  Ji HF,et al.Causal association evaluation of diabetes with Alzheimer's disease and genetic analysis of antidiabetic drugs against Alzheimer's disease.Cell Biosci 2022 Mar 10;12(1) 

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    2022-05-24 sunylz
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channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97776, encryptionId=17b59e77626, topicName=阿尔茨)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Bnia2EtH2IvyBtniaWHPQOYAicsN3IAL1ZuPV7qyALcdCiawRJdEiafMxWTxzERQW7eeKg8HfCKCRK2CJicy073C4RJg/132, createdBy=464b2500186, createdName=ms1948154235210413, createdTime=Mon Sep 26 18:47:05 CST 2022, time=2022-09-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1205423, encodeId=089e120542320, content=全面认识, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1d465591916, createdName=ms2000001386604039, createdTime=Thu Mar 24 05:35:45 CST 2022, time=2022-03-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1204824, encodeId=9b021204824db, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=fe282986430, createdName=15288412745, createdTime=Tue Mar 22 08:18:06 CST 2022, time=2022-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1204771, encodeId=48ac1204e7116, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Mon Mar 21 22:49:16 CST 2022, time=2022-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1444764, encodeId=7bd71444e6478, content=<a href='/topic/show?id=3d9291459d1' target=_blank style='color:#2F92EE;'>#评价#</a>, beContent=null, objectType=article, 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    2022-04-18 维他命
  4. 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  5. 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  6. 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  7. 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createdName=12498da4m32(暂无昵称), createdTime=Thu May 12 15:47:05 CST 2022, time=2022-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1962724, encodeId=b8471962e24dc, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Mon Apr 18 04:47:05 CST 2022, time=2022-04-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2054435, encodeId=b185205443558, content=<a href='/topic/show?id=3fde416964a' target=_blank style='color:#2F92EE;'>#基因分析#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41696, encryptionId=3fde416964a, topicName=基因分析)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b632500090, createdName=h.y200607_23674418, createdTime=Wed Dec 07 00:47:05 CST 2022, time=2022-12-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1872399, encodeId=49bd18e2399a4, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Mon Nov 07 17:47:05 CST 2022, time=2022-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1817176, encodeId=93b5181e176de, content=<a href='/topic/show?id=17b59e77626' target=_blank style='color:#2F92EE;'>#阿尔茨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97776, encryptionId=17b59e77626, topicName=阿尔茨)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Bnia2EtH2IvyBtniaWHPQOYAicsN3IAL1ZuPV7qyALcdCiawRJdEiafMxWTxzERQW7eeKg8HfCKCRK2CJicy073C4RJg/132, createdBy=464b2500186, createdName=ms1948154235210413, createdTime=Mon Sep 26 18:47:05 CST 2022, time=2022-09-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1205423, encodeId=089e120542320, content=全面认识, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1d465591916, createdName=ms2000001386604039, createdTime=Thu Mar 24 05:35:45 CST 2022, time=2022-03-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1204824, encodeId=9b021204824db, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=fe282986430, createdName=15288412745, createdTime=Tue Mar 22 08:18:06 CST 2022, time=2022-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1204771, encodeId=48ac1204e7116, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Mon Mar 21 22:49:16 CST 2022, time=2022-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1444764, encodeId=7bd71444e6478, content=<a href='/topic/show?id=3d9291459d1' target=_blank style='color:#2F92EE;'>#评价#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91459, encryptionId=3d9291459d1, topicName=评价)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1fee5134542, createdName=huagfeg, createdTime=Mon Mar 21 13:47:05 CST 2022, time=2022-03-21, status=1, ipAttribution=)]
    2022-03-24 ms2000001386604039

    全面认识

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1919413, encodeId=6140191941348, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Tue May 24 19:47:05 CST 2022, time=2022-05-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1818199, encodeId=61b51818199c8, content=<a href='/topic/show?id=4c9f9e777ac' target=_blank style='color:#2F92EE;'>#阿尔茨海#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97777, encryptionId=4c9f9e777ac, topicName=阿尔茨海)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=636e2500187, createdName=12498da4m32(暂无昵称), createdTime=Thu May 12 15:47:05 CST 2022, time=2022-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1962724, encodeId=b8471962e24dc, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Mon Apr 18 04:47:05 CST 2022, time=2022-04-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2054435, encodeId=b185205443558, content=<a href='/topic/show?id=3fde416964a' target=_blank style='color:#2F92EE;'>#基因分析#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41696, encryptionId=3fde416964a, topicName=基因分析)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b632500090, createdName=h.y200607_23674418, createdTime=Wed Dec 07 00:47:05 CST 2022, time=2022-12-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1872399, encodeId=49bd18e2399a4, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Mon Nov 07 17:47:05 CST 2022, time=2022-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1817176, encodeId=93b5181e176de, content=<a href='/topic/show?id=17b59e77626' target=_blank style='color:#2F92EE;'>#阿尔茨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97776, encryptionId=17b59e77626, topicName=阿尔茨)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Bnia2EtH2IvyBtniaWHPQOYAicsN3IAL1ZuPV7qyALcdCiawRJdEiafMxWTxzERQW7eeKg8HfCKCRK2CJicy073C4RJg/132, createdBy=464b2500186, createdName=ms1948154235210413, createdTime=Mon Sep 26 18:47:05 CST 2022, time=2022-09-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1205423, encodeId=089e120542320, content=全面认识, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1d465591916, createdName=ms2000001386604039, createdTime=Thu Mar 24 05:35:45 CST 2022, time=2022-03-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1204824, encodeId=9b021204824db, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=fe282986430, createdName=15288412745, createdTime=Tue Mar 22 08:18:06 CST 2022, time=2022-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1204771, encodeId=48ac1204e7116, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Mon Mar 21 22:49:16 CST 2022, time=2022-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1444764, encodeId=7bd71444e6478, content=<a href='/topic/show?id=3d9291459d1' target=_blank style='color:#2F92EE;'>#评价#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91459, encryptionId=3d9291459d1, topicName=评价)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1fee5134542, createdName=huagfeg, createdTime=Mon Mar 21 13:47:05 CST 2022, time=2022-03-21, status=1, ipAttribution=)]
    2022-03-22 15288412745

    学习

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1919413, encodeId=6140191941348, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Tue May 24 19:47:05 CST 2022, time=2022-05-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1818199, encodeId=61b51818199c8, content=<a href='/topic/show?id=4c9f9e777ac' target=_blank style='color:#2F92EE;'>#阿尔茨海#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97777, encryptionId=4c9f9e777ac, topicName=阿尔茨海)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=636e2500187, 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encryptionId=3fde416964a, topicName=基因分析)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b632500090, createdName=h.y200607_23674418, createdTime=Wed Dec 07 00:47:05 CST 2022, time=2022-12-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1872399, encodeId=49bd18e2399a4, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Mon Nov 07 17:47:05 CST 2022, time=2022-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1817176, encodeId=93b5181e176de, content=<a href='/topic/show?id=17b59e77626' target=_blank style='color:#2F92EE;'>#阿尔茨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97776, encryptionId=17b59e77626, topicName=阿尔茨)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Bnia2EtH2IvyBtniaWHPQOYAicsN3IAL1ZuPV7qyALcdCiawRJdEiafMxWTxzERQW7eeKg8HfCKCRK2CJicy073C4RJg/132, createdBy=464b2500186, createdName=ms1948154235210413, createdTime=Mon Sep 26 18:47:05 CST 2022, time=2022-09-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1205423, encodeId=089e120542320, content=全面认识, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1d465591916, createdName=ms2000001386604039, createdTime=Thu Mar 24 05:35:45 CST 2022, time=2022-03-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1204824, encodeId=9b021204824db, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=fe282986430, createdName=15288412745, createdTime=Tue Mar 22 08:18:06 CST 2022, time=2022-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1204771, encodeId=48ac1204e7116, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Mon Mar 21 22:49:16 CST 2022, time=2022-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1444764, encodeId=7bd71444e6478, content=<a href='/topic/show?id=3d9291459d1' target=_blank style='color:#2F92EE;'>#评价#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91459, encryptionId=3d9291459d1, topicName=评价)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1fee5134542, createdName=huagfeg, createdTime=Mon Mar 21 13:47:05 CST 2022, time=2022-03-21, status=1, ipAttribution=)]
    2022-03-21 1209e435m98(暂无昵称)

    学习了,谢谢分享

    0

  10. [GetPortalCommentsPageByObjectIdResponse(id=1919413, encodeId=6140191941348, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Tue May 24 19:47:05 CST 2022, time=2022-05-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1818199, encodeId=61b51818199c8, content=<a href='/topic/show?id=4c9f9e777ac' target=_blank style='color:#2F92EE;'>#阿尔茨海#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97777, encryptionId=4c9f9e777ac, topicName=阿尔茨海)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=636e2500187, 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channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97776, encryptionId=17b59e77626, topicName=阿尔茨)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Bnia2EtH2IvyBtniaWHPQOYAicsN3IAL1ZuPV7qyALcdCiawRJdEiafMxWTxzERQW7eeKg8HfCKCRK2CJicy073C4RJg/132, createdBy=464b2500186, createdName=ms1948154235210413, createdTime=Mon Sep 26 18:47:05 CST 2022, time=2022-09-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1205423, encodeId=089e120542320, content=全面认识, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1d465591916, createdName=ms2000001386604039, createdTime=Thu Mar 24 05:35:45 CST 2022, time=2022-03-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1204824, encodeId=9b021204824db, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=fe282986430, createdName=15288412745, createdTime=Tue Mar 22 08:18:06 CST 2022, time=2022-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1204771, encodeId=48ac1204e7116, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Mon Mar 21 22:49:16 CST 2022, time=2022-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1444764, encodeId=7bd71444e6478, content=<a href='/topic/show?id=3d9291459d1' target=_blank style='color:#2F92EE;'>#评价#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91459, encryptionId=3d9291459d1, topicName=评价)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1fee5134542, createdName=huagfeg, createdTime=Mon Mar 21 13:47:05 CST 2022, time=2022-03-21, status=1, ipAttribution=)]
    2022-03-21 huagfeg

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