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Am Heart J:糖尿病及其胰岛素治疗与CABG患者临床转归差相关

2014-10-29 高晓方 译 医学论坛网

美国一项研究表明,在冠脉旁路移植(CABG)患者中,伴糖尿病患者的静脉移植失败发生率与未伴者相似,但其临床转归较差。胰岛素治疗者的临床转归则显著差于非治疗者。论文于10月23日在线发表于《美国心脏杂志》(Am Heart J)。 此项研究利用来自于PREVENT IV的3014例患者数据,在伴和未伴糖尿病以及GABG前接受和未接受胰岛素治疗的患者中分析了血管造影和临床转归。利用Logis

美国一项研究表明,在冠脉旁路移植(CABG)患者中,伴糖尿病患者的静脉移植失败发生率与未伴者相似,但其临床转归较差。胰岛素治疗者的临床转归则显著差于非治疗者。论文于10月23日在线发表于《美国心脏杂志》(Am Heart J)。

此项研究利用来自于PREVENT IV的3014例患者数据,在伴和未伴糖尿病以及GABG前接受和未接受胰岛素治疗的患者中分析了血管造影和临床转归。利用Logistic回归和Cox比例风险模型对基线变量差异进行校正。评估糖尿病及其治疗与1年血管造影移植物失败和5年临床转归的相关性。

结果显示,1139例(37.8%)患者伴有糖尿病,其中305例(26.8%)接受了胰岛素治疗。在伴和未伴糖尿病的患者中1年静脉移植失败的发生率相似;然而在糖尿病患者中,胰岛素治者的静脉移植失败率较非治疗者有升高趋势。5年时,伴糖尿病患者的死亡、心梗或重复血运重建发生率高于未伴患者[校正危险比(HR) 1.57;P<0.001],胰岛素治疗者亦较高(校正HR 1.15;P=0.02)。

原始出处:

Masaya Koshizaka, MD, PhD, Renato D. Lopes, MD, PhD, Eric M. Reyes, PhD, C. Michael Gibson, MD, Phillip J. Schulte, PhD, Gail E. Hafley, MS, Adrian F. Hernandez, MD, MHS, Jennifer B. Green, MD, Nicholas T. Kouchoukos, MD, Robert M. Califf, MD, T. Bruce Ferguson, MD, Eric D. Peterson, MD, MPH, John H. Alexander, MD, MHS.Long-term Clinical and Angiographic Outcomes in Patients with Diabetes Undergoing Coronary Artery Bypass Graft Surgery: Results from the PREVENT IV Trial.American Heart Journal.DOI: http://dx.doi.org/10.1016/j.ahj.2014.10.013

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    2015-06-08 ljjj1053

    好好学习学习

    0

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    2015-04-11 x35042875

    控制好糖尿病可能提高肝硬化患者的预后。

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=26322, encodeId=f4dd2632235, content=好好学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=146, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=ac181616815, createdName=ljjj1053, createdTime=Mon Jun 08 14:07:00 CST 2015, time=2015-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=20509, encodeId=4ab72050987, content=控制好糖尿病可能提高肝硬化患者的预后。, beContent=null, objectType=article, channel=null, level=null, likeNumber=147, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20150920/IMG55FDE671A89482379.jpg, createdBy=cef3108336, createdName=x35042875, createdTime=Sat Apr 11 23:04:00 CST 2015, time=2015-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1749502, encodeId=8dc11e4950265, content=<a href='/topic/show?id=be7c8385345' target=_blank style='color:#2F92EE;'>#胰岛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83853, encryptionId=be7c8385345, topicName=胰岛)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a7a536274692, createdName=baoya, createdTime=Fri Oct 31 15:27:00 CST 2014, time=2014-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1970379, encodeId=fa3b19e0379b2, content=<a href='/topic/show?id=962a2306488' target=_blank style='color:#2F92EE;'>#临床转归#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23064, encryptionId=962a2306488, topicName=临床转归)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e080359, createdName=surilei, createdTime=Wed Oct 14 15:27:00 CST 2015, time=2015-10-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1355927, encodeId=3e3b135592e45, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Fri Oct 31 00:27:00 CST 2014, time=2014-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1514613, encodeId=d68515146138c, content=<a href='/topic/show?id=c8d68389847' target=_blank style='color:#2F92EE;'>#胰岛素治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83898, encryptionId=c8d68389847, topicName=胰岛素治疗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e51610667367, createdName=zjshifan_98647309, createdTime=Fri Oct 31 00:27:00 CST 2014, time=2014-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1562266, encodeId=9f8e1562266a5, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Fri Oct 31 00:27:00 CST 2014, time=2014-10-31, status=1, ipAttribution=)]
    2014-10-31 baoya
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    2014-10-31 zhaojie88
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