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Neurology:颅内动脉粥样硬化与夹层引起的缺血性卒中结局差异

2018-10-06 xing.T MedSci原创

由此可见,考虑到ICAS患者ICAD的高患病率以及ICAD和ICAS之间的结局差异,HR-MRI可能是该类人群有用的鉴别诊断工具。

近日,神经病学领域权威取杂志Neurology上发表了一篇研究文章,研究人员旨在使用高分辨率MRI(HR-MRI)比较非创伤性颅内动脉夹层(ICAD)和颅内动脉粥样硬化狭窄(ICAS)患者的结局。

研究人员使用HR-MRI对因颅内闭塞性疾病引起的急性症状性脑血管病且管腔图像上显示无夹层的患者进行了一项前瞻性研究。患者被随访了27.9±19.3个月。研究人员比较了ICAD患者(HR-MRI夹层且无斑块)和ICAS(HR-MRI上的动脉粥样硬化斑块)患者的功能结局、复发和血管状态的变化。

研究人员纳入了312例患者(平均年龄为59.0±14.2岁;男性占58.3%),其中113例患有ICAD,199例患有ICAS。在调整其它因素后,各组之间症状发作后第90天的功能结局(通过改良Rankin量表评分来衡量)没有差异(p=0.095)。然而,ICAD组相关血管区域的复发性缺血性脑血管病(7例,6.2%)低于ICAS组(37例,18.6%)。 ICAD是疾病复发的重要独立决定因素(风险比为0.43; 95%置信区间为0.19-0.98)。随后的血管研究中血管狭窄的改善在ICAD组(50.7%)中比在ICAS组(11.6%)中更常见。ICAD是血管改善的独立决定因素(比值比为7.94; 95%置信区间为3.32-19.01)。

由此可见,考虑到ICAS患者ICAD的高患病率以及ICAD和ICAS之间的结局差异,HR-MRI可能是该类人群有用的鉴别诊断工具。

原始出处:

Jaewon Shin,et al.Outcomes after ischemic stroke caused by intracranial atherosclerosis vs dissection.neurology.2018. http://n.neurology.org/content/early/2018/10/05/WNL.0000000000006459

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  5. [GetPortalCommentsPageByObjectIdResponse(id=1893104, encodeId=0e531893104f2, content=<a href='/topic/show?id=c738e93521f' target=_blank style='color:#2F92EE;'>#缺血性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79352, encryptionId=c738e93521f, topicName=缺血性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智慧医人, createdTime=Wed May 01 02:39:00 CST 2019, time=2019-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2053352, encodeId=8f91205335257, content=<a href='/topic/show?id=317b10038659' target=_blank style='color:#2F92EE;'>#颅内动脉粥样硬化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100386, encryptionId=317b10038659, topicName=颅内动脉粥样硬化)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=644e456, createdName=vera_1203, createdTime=Fri May 31 12:39:00 CST 2019, time=2019-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1806275, encodeId=21b618062e525, content=<a href='/topic/show?id=b649e9358fa' target=_blank style='color:#2F92EE;'>#缺血性卒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79358, encryptionId=b649e9358fa, topicName=缺血性卒)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=636e2500187, createdName=12498da4m32(暂无昵称), createdTime=Sat Sep 14 17:39:00 CST 2019, time=2019-09-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1944559, encodeId=d3b619445592d, content=<a href='/topic/show?id=411de6300ad' target=_blank style='color:#2F92EE;'>#粥样硬化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76300, encryptionId=411de6300ad, topicName=粥样硬化)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b30d401, createdName=huangshifeng, createdTime=Fri May 10 20:39:00 CST 2019, time=2019-05-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2000602, encodeId=a1e6200060260, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Thu Nov 08 07:39:00 CST 2018, time=2018-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=348229, encodeId=888c34822982, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82311653708, createdName=医者仁心5538, createdTime=Sat Oct 06 20:32:54 CST 2018, time=2018-10-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026166, encodeId=68bb102616623, content=卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Sat Oct 06 19:39:00 CST 2018, time=2018-10-06, status=1, ipAttribution=)]
    2018-11-08 yinhl1978
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    2018-10-06 医者仁心5538

    学习了

    0

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    2018-10-06 健健

    卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!

    0

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