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ArQule在第30届EORTC / AACR / NCI研讨会上介绍了ARQ 751的全新数据

2018-11-19 MedSci MedSci原创

ArQuleARQ751Akt
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ArQule制药在爱尔兰都柏林举行的第30届EORTC / AACR / NCI研讨会上，以三张海报的形式介绍ARQ 751的临床和临床前数据。所提供的数据突出了来自ARQ 751-101的临床数据，ARQ 751-101是一项针对具有AKT，PI3K或PTEN遗传突变的难治性和/或转移性成年肿瘤患者的I期临床研究。

ArQule制药在爱尔兰都柏林举行的第30届EORTC / AACR / NCI研讨会上，以三张海报的形式介绍ARQ 751的临床和临床前数据。所提供的数据突出了来自ARQ 751-101的临床数据，ARQ 751-101是一项针对具有AKT，PI3K或PTEN遗传突变的难治性和/或转移性成年肿瘤患者的I期临床研究。

ARQ 751-101的临床数据亮点和主要结论包括：

1. ARQ 751在具有AKT，PI3K或PTEN遗传突变晚期实体瘤患者中具有剂量递增效应；

2. ARQ 751的剂量从5 mg QD增加到75 mg QD时表现出可控的毒性，建议的II期剂量确定为75 mg QD；

3. 在ER + / PR + / HER2- IV期乳腺癌患者中观察到临床活动的证据。

ArQule首席医疗官Brian Schwartz博士说：“ARQ 751可控的安全性和生物活性的初步证据，支持了ARQ 751作为单一疗法或与其他抗癌药物联合的治疗方案。ARQ 751作为一种高度特异性的AKT变构抑制剂，在治疗具有AKT / PI3K / PTEN途径突变的实体瘤患者方面具有巨大潜力。ARQ 751-101所提供的数据非常令人鼓舞，并证明了临床活动的初步迹象和良好的安全性。在ArQule，我们致力于开发癌症靶向疗法，为患者提供有效的新治疗方案，特别是患有晚期或复发疾病的患者”。


原始出处：

http://www.firstwordpharma.com/node/1605303#axzz5XAXlsKfr

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    2019-01-27 kcb069

    #研讨会#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1994816, encodeId=ad9f1994816d0, content=<a href='/topic/show?id=3d51e345936' target=_blank style='color:#2F92EE;'>#研讨会#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73459, encryptionId=3d51e345936, topicName=研讨会)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=87b1109, createdName=kcb069, createdTime=Sun Jan 27 17:28:00 CST 2019, time=2019-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1933747, encodeId=8b2b1933e47df, content=<a href='/topic/show?id=71a81258504' target=_blank style='color:#2F92EE;'>#NCI#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12585, encryptionId=71a81258504, topicName=NCI)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0ee7414, createdName=lanyan20020086, createdTime=Sun Aug 04 23:28:00 CST 2019, time=2019-08-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1400402, encodeId=37d8140040289, content=<a href='/topic/show?id=e7c018e7af' target=_blank style='color:#2F92EE;'>#ACR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1877, encryptionId=e7c018e7af, topicName=ACR)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=19792261142, createdName=10518094zz, createdTime=Wed Nov 21 05:28:00 CST 2018, time=2018-11-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1551986, encodeId=495e1551986be, content=<a href='/topic/show?id=169c166430' target=_blank style='color:#2F92EE;'>#AACR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1664, encryptionId=169c166430, topicName=AACR)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6b2714248200, createdName=Luyuxie_14, createdTime=Wed Nov 21 05:28:00 CST 2018, time=2018-11-21, status=1, ipAttribution=)]
    2019-08-04 lanyan20020086

    #NCI#

    0

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    2018-11-21 10518094zz

    #ACR#

    0

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    2018-11-21 Luyuxie_14

    #AACR#

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