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JAHA:慢性心力衰竭且左心室射血分数降低患者脓毒症死亡率和预测因子

2018-10-05 xing.T MedSci原创

由此可见,脓毒症是CHF患者死亡的主要原因,并且与其它死亡原因具有不同的风险标记,表明它可能需要有针对性的预防策略。

血管性死亡在慢性心力衰竭(CHF)患者中越来越常见,但其原因仍未得到很好的归纳。近日,血管疾病领域权威杂志JAHA上发表了一篇研究文章,研究人员的目的是确定CHF患者脓毒症死亡的患病率,并确定其风险标记谱。

研究人员对2006年至2014年期间在英国4家医院的1802名CHF且左心室射血分数≤45%的患者进行了一项前瞻性队列研究。在随访期为10.3年(平均4年)期间确定死亡原因。竞争风险回归用于定义脓毒症,其它非心血管疾病、进行性心力衰竭和心脏性猝死与已知的心力衰竭预后标志物相关的特异性风险比。

在737例死亡病例中,173例(23.5%)患者死于脓毒症; 呼吸道感染占这些事件的69.9%(n=121)。死于脓毒症的病例年龄较大,血小板计数较高,慢性阻塞性肺病患病率高于其它原因死亡者。脓毒症死亡与较大年龄(风险比=1.05; 95%置信区间为1.03-1.07)、较高的慢性阻塞性肺病患病率(2.43; 1.74-3.40)、男性(1.73; 1.16-2.60)、较低血清维生素D对数(0.68; 0.49-0.95)、较高的血小板计数(1.002; 1.000-1.005)相关独立,相对于非败血症死亡者。已知的心力衰竭预后标志物表现出与败血症死亡、其它非心血管死亡、进行性心力衰竭死亡和心源性猝死不同的相关性模式。

由此可见,脓毒症是CHF患者死亡的主要原因,并且与其它死亡原因具有不同的风险标记,表明它可能需要有针对性的预防策略。

原始出处:

Andrew M. N..et al. Prevalence and Predictors of Sepsis Death in Patients With Chronic Heart Failure and Reduced Left Ventricular Ejection Fraction.JAHA.2018. https://www.ahajournals.org/doi/10.1161/JAHA.118.009684

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    2019-02-07 13718711b3m

    非常不错的临床经验,值得借鉴的学习资讯,学习了,涨知识,获益匪浅,谢谢分享

    0

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    2018-12-08 jyzxjiangqin

    慢性心力衰竭患者的治疗。

    0

  4. 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/02/27/c53a212859edcad4f60a54feffff50bb.jpg, createdBy=67cf1525321, createdName=13718711b3m, createdTime=Wed Oct 10 12:01:40 CST 2018, time=2018-10-10, status=1, ipAttribution=)]
    2018-11-25 jyzxjiangqin

    慢性心力衰竭患者的治疗。

    0

  5. 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/02/27/c53a212859edcad4f60a54feffff50bb.jpg, createdBy=67cf1525321, createdName=13718711b3m, createdTime=Wed Oct 10 12:01:40 CST 2018, time=2018-10-10, status=1, ipAttribution=)]
    2018-11-13 jyzxjiangqin

    慢性心衰患者评估保健。

    0

  6. 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/02/27/c53a212859edcad4f60a54feffff50bb.jpg, createdBy=67cf1525321, createdName=13718711b3m, createdTime=Wed Oct 10 12:01:40 CST 2018, time=2018-10-10, status=1, ipAttribution=)]
    2018-11-08 13718711b3m

    很好的学习资料,值得借鉴,学习了,获益匪浅,感谢分享!谢谢

    0

  7. 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/02/27/c53a212859edcad4f60a54feffff50bb.jpg, createdBy=67cf1525321, createdName=13718711b3m, createdTime=Wed Oct 10 12:01:40 CST 2018, time=2018-10-10, status=1, ipAttribution=)]
    2018-11-03 jyzxjiangqin

    慢性心力衰竭患者的治疗。

    0

  8. 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/02/27/c53a212859edcad4f60a54feffff50bb.jpg, createdBy=67cf1525321, createdName=13718711b3m, createdTime=Wed Oct 10 12:01:40 CST 2018, time=2018-10-10, status=1, ipAttribution=)]
    2018-10-20 jyzxjiangqin

    慢性心力衰竭患者的治疗。

    0

  9. 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/02/27/c53a212859edcad4f60a54feffff50bb.jpg, createdBy=67cf1525321, createdName=13718711b3m, createdTime=Wed Oct 10 12:01:40 CST 2018, time=2018-10-10, status=1, ipAttribution=)]
    2018-10-11 jyzxjiangqin

    慢性心力衰竭患者的治疗。

    0

  10. 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/02/27/c53a212859edcad4f60a54feffff50bb.jpg, createdBy=67cf1525321, createdName=13718711b3m, createdTime=Wed Oct 10 12:01:40 CST 2018, time=2018-10-10, status=1, ipAttribution=)]
    2018-10-10 13718711b3m

    学习了,非常不错的临床病例,值得借鉴的临床经验,受益匪浅,感谢分享!

    0

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对闪烁光反应性的视网膜微血管扩张功能在CHF患者中有所受损。RVA可能是一种新的并且有用的方法,以无创和无辐射的方式来监测心力衰竭患者的血管异常。

Heart:慢性心力衰竭患者的社会经济剥夺和临床结局之间的相关性分析!

由此可见,CHF患者社会经济剥夺与因过度非心血管事件所致的死亡和住院风险增加相关。

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