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Clinica Chimica Acta:降钙素原作为危重癌症患者血流感染的预测因子和支持性治疗需求的应用

2020-08-09 MedSci原创 MedSci原创

本研究评估了降钙素原(PCT)在预测有无中性粒细胞减少症的危重癌症患者细菌血流感染(BSI)中的诊断价值。

本研究评估了降钙素原(PCT)在预测有无中性粒细胞减少症的危重癌症患者细菌血流感染(BSI)中的诊断价值。还研究了PCT作为重症监护病房(ICU)支持治疗(血管加压药、有创机械通气和肾脏替代治疗(RRT))的预后标志物的作用。

研究人员回顾性分析了疑似败血症的成年癌症患者的2200 PCT和血液培养。 主要结果是BSI,由阳性血液培养确定,在PCT收集后72小时内收集。

研究结果表明,中位PCT值在遇到BSI时较高(3.2 vs 0.5 ng/ml, p < 0.001)。ROC曲线下面积为0.726 (95%CI 0.698, 0.754)。PCT > 2.0 ng/ml与BSI更大的可能性显著相关,中性粒细胞减少患者(OR 9.09, 95%CI: 4.39, 18.79)显著强于非中性粒细胞减少患者(OR 4.00, 95%CI: 3.13, 5.10),交互作用p = 0.036)。PCT > 2.0与ICU(或1.82 (95% CI 1.31, 2.53), p < 0.001)和RRT(或2.20 (95% CI 1.24, 3.91), p = 0.007)入院时的血管加压素需求相关。

在有无中性粒细胞减少症的危重症癌症患者中,降钙素原是一种公平的鉴别BSI的指标,而ICU中PCT> 2.0 ng / ml的可能性更大。

原始出处:

Amanda G.Blouin,Meier Hsu,Utility of procalcitonin as a predictor of bloodstream infections and supportive modality requirements in critically ill cancer patients

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    2020-11-08 windight
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    2020-11-02 沙村的风

    学习了。

    0

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