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Diabetes Obes Metab:体脂分布比整体肥胖更能预测全因死亡率!

2017-07-04 xing.T MedSci原创

由此可见,增加的VSR是全因死亡率的独立预测因子。这表明脂肪堆积物的位置可能比实际的身体脂肪量更重要。

直接测量的体脂与全因死亡率之间的关系很少被研究。近日,代谢内分泌疾病领域权威杂志Diabetes Obesity & Metabolism上发表了一篇研究文章,该研究的目的是探讨CT测量的身体脂肪,包括内脏脂肪面积(VFA)和皮下脂肪面积(SFA)对死亡的预测意义。

这项研究纳入了于2007年至2015年期间在一所大学附属保健中心接受腹部CT检查作为健康检查一部分的36656名参与者。其中,在2016年5月记录了生命状态数据的32593名参与者被纳入最后的分析中。该研究评估的主要因素有VFA、SFA和内脏与皮下脂肪面积比(VSR),并且该研究的主要终点为全因死亡率。

该研究平均5.7 年的随访期间,有253人发生死亡。增加的SFA与降低的全因死亡率有关,而增加的VFA和VSR与增加的全因死亡率相关。相比于体重指数(BMI)的预测能力,SFA和VSR显示出比BMI更大的曲线下面积。在Kaplan Meier生存曲线分析中,增加的SFA和VSR分别与全因死亡风险降低和增加相关。然而,在多变量Cox比例风险回归分析中,只有VSR与全因死亡率独立相关。此外,这种关系与增加的VSR对代谢的不良影响相平行。

由此可见,增加的VSR是全因死亡率的独立预测因子。这表明脂肪堆积物的位置可能比实际的身体脂肪量更重要。

原始出处:

Sung Woo Lee,et al. Body fat distribution is more predictive of all-cause mortality than overall adiposity. Diabetes Obesity & Metabolism.2017. http://onlinelibrary.wiley.com/doi/10.1111/dom.13050/full

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    2017-09-05 一闲
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    2018-04-04 guojianrong
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    2017-07-04 首丘

    学习了,谢谢分享!

    0

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    2017-07-04 三生有幸9135

    学习一下谢谢分享

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