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Leuk Lymphoma：AML患者使用泊沙康唑的成本与传统抗真菌药相媲美

2017-08-14 吴星 环球医学

泊沙康唑霉菌感染
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对于霉菌感染的预防，泊沙康唑已经表现出比氟康唑和伊曲康唑的临床优越性，然而泊沙康唑的药物成本较高。2017年12月，发表在《Leuk Lymphoma》的一项研究调查了正接受诱导化疗的急性髓性白血病（AML）患者泊沙康唑抗真菌预防的经济学。



对于霉菌感染的预防，泊沙康唑已经表现出比氟康唑和伊曲康唑的临床优越性，然而泊沙康唑的药物成本较高。2017年12月，发表在《Leuk Lymphoma》的一项研究调查了正接受诱导化疗的急性髓性白血病（AML）患者泊沙康唑抗真菌预防的经济学。

为此，研究人员旨在分析AML患者诱导化疗期间，预防性泊沙康唑（510例，58%）、伊曲康唑（120例，14%）或氟康唑（175例，20%）的抗真菌预防成本。对于抗真菌预防的估计成本以及随后全身性抗真菌治疗恶性侵袭性真菌感染（IFI）的成本，泊沙康唑比伊曲康唑和氟康唑高。基于Monte Carlo模拟，伊曲康唑具有最高的成本，其次是泊沙康唑和氟康唑，并且，泊沙康唑治疗者的总生存期最高。

因此，AML患者使用预防性泊沙康唑的成本可以与传统的抗真菌药物相媲美。

原始出处：

Busca A， Lessi F， Verga L， et al. SEIFEM 2010-E： economic evaluation of posaconazole for antifungal prophylaxis in patients with acute myeloid leukemia receiving induction chemotherapy. Leuk Lymphoma. 2017 Dec；58(12)：2859-2864. doi： 10.1080/10428194.2017.1318438. Epub 2017 May 16.

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    2018-02-24 12498da4m32(暂无昵称)

    #抗真菌药#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1937012, encodeId=3049193e012df, content=<a href='/topic/show?id=2300555e0c9' target=_blank style='color:#2F92EE;'>#抗真菌药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55570, encryptionId=2300555e0c9, topicName=抗真菌药)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=636e2500187, createdName=12498da4m32(暂无昵称), createdTime=Sat Feb 24 12:10:00 CST 2018, time=2018-02-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1775736, encodeId=b7ea1e75736bb, content=<a href='/topic/show?id=19e45556efa' target=_blank style='color:#2F92EE;'>#抗真菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55567, encryptionId=19e45556efa, topicName=抗真菌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=596c38798743, createdName=amy0563, createdTime=Tue Oct 31 17:10:00 CST 2017, time=2017-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1689293, encodeId=54dd1689293ef, content=<a href='/topic/show?id=1ddd11158fb' target=_blank style='color:#2F92EE;'>#lymphoma#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11158, encryptionId=1ddd11158fb, topicName=lymphoma)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=45ae28785510, createdName=ms5187542471278033, createdTime=Thu Jul 05 10:10:00 CST 2018, time=2018-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1353717, encodeId=0d021353e1746, content=<a href='/topic/show?id=dddce266537' target=_blank style='color:#2F92EE;'>#真菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72665, encryptionId=dddce266537, topicName=真菌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Wed Aug 16 09:10:00 CST 2017, time=2017-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=233544, encodeId=4fc223354415, content=学习了受益匪浅。, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Mon Aug 14 19:57:06 CST 2017, time=2017-08-14, status=1, ipAttribution=)]
    2017-10-31 amy0563

    #抗真菌#

    0

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    2018-07-05 ms5187542471278033

    #lymphoma#

    0

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    2017-08-16 zhaojie88

    #真菌#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1937012, encodeId=3049193e012df, content=<a href='/topic/show?id=2300555e0c9' target=_blank style='color:#2F92EE;'>#抗真菌药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55570, encryptionId=2300555e0c9, topicName=抗真菌药)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=636e2500187, createdName=12498da4m32(暂无昵称), createdTime=Sat Feb 24 12:10:00 CST 2018, time=2018-02-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1775736, encodeId=b7ea1e75736bb, content=<a href='/topic/show?id=19e45556efa' target=_blank style='color:#2F92EE;'>#抗真菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55567, encryptionId=19e45556efa, topicName=抗真菌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=596c38798743, createdName=amy0563, createdTime=Tue Oct 31 17:10:00 CST 2017, time=2017-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1689293, encodeId=54dd1689293ef, content=<a href='/topic/show?id=1ddd11158fb' target=_blank style='color:#2F92EE;'>#lymphoma#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11158, encryptionId=1ddd11158fb, topicName=lymphoma)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=45ae28785510, createdName=ms5187542471278033, createdTime=Thu Jul 05 10:10:00 CST 2018, time=2018-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1353717, encodeId=0d021353e1746, content=<a href='/topic/show?id=dddce266537' target=_blank style='color:#2F92EE;'>#真菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72665, encryptionId=dddce266537, topicName=真菌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Wed Aug 16 09:10:00 CST 2017, time=2017-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=233544, encodeId=4fc223354415, content=学习了受益匪浅。, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Mon Aug 14 19:57:06 CST 2017, time=2017-08-14, status=1, ipAttribution=)]
    2017-08-14 131****1460

    学习了受益匪浅。

    0

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