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JCI:艾滋病研究突破:团队研发精准方法,让HIV无处可逃!

2017-12-22 Lily 来宝网

杜克大学人类疫苗研究所的研究人员领导了一个更准确的方法来衡量在人群中艾滋病毒感染的发生率,这将有助于改善全世界艾滋病的研究和预防战略。

团队开发了更准确的工具来跟踪新的HIV感染】杜克大学人类疫苗研究所的研究人员领导了一个更准确的方法来衡量在人群中艾滋病毒感染的发生率,这将有助于改善全世界艾滋病的研究和预防战略。

新方法更准确地确定了新的与长期感染,确定在何处目标公共卫生措施和研究的重要区别,以及评价干预措施是否成功减少艾滋病毒传播。

研究人员表示:“最近艾滋病的治疗取得了很大的进步,包括治疗和预防HIV感染的有效抗逆转录病毒药物,已经从根本上改变了艾滋病毒领域的景观。”这项研究于12月21日在《JCI》杂志上发表。

在报告中,研究人员指出:"为帮助确定最有效的预防战略,迫切需要改进从已有感染中分类新感染的方法。”研究人员们致力于开发一种方法来衡量艾滋病毒的发病率,同时考虑到目前流行的独特特征,还能利用最新的见解,了解病毒和身体在感染的早期阶段以及如何相互作用。结果是鉴定天然存在的抗体生物标记的新组合的测定,得到了可使用的4个生物标记的有希望的集合。

新的测定更准确。“更准确的HIV发病率测试可以大大降低研究人员的成本,因为他们需要更小的样本量来参加研究。”此外,从公共卫生的角度来看,更准确的艾滋病毒发病率测试将有助于查明近期感染的热点,因此,预防工作可以更好地针对发生疫情的地方。

原始出处:

James J. Knox, Marcus Buggert, Lela Kardava, et al. T-bet+ B cells are induced by human viral infections and dominate the HIV gp140 response. Citation Information: JCI Insight. 2017;2(8):e92943. doi:10.1172/jci.insight.92943.

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    2017-12-24 lqvr
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