Baidu
map

肿瘤科

订阅

MedSci主页 / 所有栏目 / 肿瘤科

由于心脏安全性，MCL-1抑制剂AMG 397的早期研究已被暂停

2019-09-14 Allan MedSci原创

MCL-1抑制剂Mg397心脏安全性
关注

Amgen在其肿瘤学管道的更新中披露，由于心脏毒性的安全信号，实验性小分子MCL-1抑制剂AMG 397的I期研究已被搁置。

MCL-1蛋白是BCL-2蛋白家族中重要的抗凋亡蛋白，至少含有一种BCL-2同源的BH结构域，是线粒体凋亡途径的关键调节因子，而含有多BH结构域的效应子BAX、BAK和BOK以及仅BH3蛋白如BIM和BAD则具有促凋亡功能。

MCL-1过表达不仅与肿瘤发生发展密切相关，而且与靶向治疗和传统化疗药物耐药密切相关，然而靶向MCL-1小分子抑制剂的研发目前尚具挑战性。Amgen在其肿瘤学管道的更新中披露，由于心脏毒性的安全信号，实验性小分子MCL-1抑制剂AMG 397的I期研究已被搁置。去年开始的AMG 397剂量递增试验迄今已招募了24例多发性骨髓瘤、非霍奇金淋巴瘤或急性髓性白血病（AML）患者。


原始出处：

http://www.firstwordpharma.com/node/1666088#axzz5zU18ApSM

本文系梅斯医学（MedSci）原创编译整理，转载需授权!

版权声明：
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料，版权均属于梅斯医学所有。非经授权，任何媒体、网站或个人不得转载，授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章，或“梅斯号”自媒体发布的文章，仅系出于传递更多信息之目的，本站仅负责审核内容合规，其内容不代表本站立场，本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系，我们将立即进行删除处理。
在此留言
评论区 (4)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=2079878, encodeId=a64220e98784f, content=<a href='/topic/show?id=4a5611382b3' target=_blank style='color:#2F92EE;'>#MCL-1抑制剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11382, encryptionId=4a5611382b3, topicName=MCL-1抑制剂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5a6b240, createdName=俅侠, createdTime=Mon Dec 09 05:56:00 CST 2019, time=2019-12-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1852123, encodeId=db371852123e1, content=<a href='/topic/show?id=f0a254918f0' target=_blank style='color:#2F92EE;'>#抑制剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54918, encryptionId=f0a254918f0, topicName=抑制剂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=44a360, createdName=jklm09, createdTime=Fri Jun 26 05:56:00 CST 2020, time=2020-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1439296, encodeId=b89314392962f, content=<a href='/topic/show?id=d087241211' target=_blank style='color:#2F92EE;'>#AMG#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2412, encryptionId=d087241211, topicName=AMG)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Mon Sep 16 06:56:00 CST 2019, time=2019-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1495779, encodeId=c2cd1495e79a2, content=<a href='/topic/show?id=904e11381c1' target=_blank style='color:#2F92EE;'>#Mcl-1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11381, encryptionId=904e11381c1, topicName=Mcl-1)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=59d29195732, createdName=wangtianj2010@, createdTime=Mon Sep 16 06:56:00 CST 2019, time=2019-09-16, status=1, ipAttribution=)]
    2019-12-09 俅侠

    #MCL-1抑制剂#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=2079878, encodeId=a64220e98784f, content=<a href='/topic/show?id=4a5611382b3' target=_blank style='color:#2F92EE;'>#MCL-1抑制剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11382, encryptionId=4a5611382b3, topicName=MCL-1抑制剂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5a6b240, createdName=俅侠, createdTime=Mon Dec 09 05:56:00 CST 2019, time=2019-12-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1852123, encodeId=db371852123e1, content=<a href='/topic/show?id=f0a254918f0' target=_blank style='color:#2F92EE;'>#抑制剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54918, encryptionId=f0a254918f0, topicName=抑制剂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=44a360, createdName=jklm09, createdTime=Fri Jun 26 05:56:00 CST 2020, time=2020-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1439296, encodeId=b89314392962f, content=<a href='/topic/show?id=d087241211' target=_blank style='color:#2F92EE;'>#AMG#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2412, encryptionId=d087241211, topicName=AMG)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Mon Sep 16 06:56:00 CST 2019, time=2019-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1495779, encodeId=c2cd1495e79a2, content=<a href='/topic/show?id=904e11381c1' target=_blank style='color:#2F92EE;'>#Mcl-1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11381, encryptionId=904e11381c1, topicName=Mcl-1)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=59d29195732, createdName=wangtianj2010@, createdTime=Mon Sep 16 06:56:00 CST 2019, time=2019-09-16, status=1, ipAttribution=)]
    2020-06-26 jklm09

    #抑制剂#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=2079878, encodeId=a64220e98784f, content=<a href='/topic/show?id=4a5611382b3' target=_blank style='color:#2F92EE;'>#MCL-1抑制剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11382, encryptionId=4a5611382b3, topicName=MCL-1抑制剂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5a6b240, createdName=俅侠, createdTime=Mon Dec 09 05:56:00 CST 2019, time=2019-12-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1852123, encodeId=db371852123e1, content=<a href='/topic/show?id=f0a254918f0' target=_blank style='color:#2F92EE;'>#抑制剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54918, encryptionId=f0a254918f0, topicName=抑制剂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=44a360, createdName=jklm09, createdTime=Fri Jun 26 05:56:00 CST 2020, time=2020-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1439296, encodeId=b89314392962f, content=<a href='/topic/show?id=d087241211' target=_blank style='color:#2F92EE;'>#AMG#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2412, encryptionId=d087241211, topicName=AMG)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Mon Sep 16 06:56:00 CST 2019, time=2019-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1495779, encodeId=c2cd1495e79a2, content=<a href='/topic/show?id=904e11381c1' target=_blank style='color:#2F92EE;'>#Mcl-1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11381, encryptionId=904e11381c1, topicName=Mcl-1)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=59d29195732, createdName=wangtianj2010@, createdTime=Mon Sep 16 06:56:00 CST 2019, time=2019-09-16, status=1, ipAttribution=)]
    2019-09-16 zhouqu_8

    #AMG#

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=2079878, encodeId=a64220e98784f, content=<a href='/topic/show?id=4a5611382b3' target=_blank style='color:#2F92EE;'>#MCL-1抑制剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11382, encryptionId=4a5611382b3, topicName=MCL-1抑制剂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5a6b240, createdName=俅侠, createdTime=Mon Dec 09 05:56:00 CST 2019, time=2019-12-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1852123, encodeId=db371852123e1, content=<a href='/topic/show?id=f0a254918f0' target=_blank style='color:#2F92EE;'>#抑制剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54918, encryptionId=f0a254918f0, topicName=抑制剂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=44a360, createdName=jklm09, createdTime=Fri Jun 26 05:56:00 CST 2020, time=2020-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1439296, encodeId=b89314392962f, content=<a href='/topic/show?id=d087241211' target=_blank style='color:#2F92EE;'>#AMG#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2412, encryptionId=d087241211, topicName=AMG)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Mon Sep 16 06:56:00 CST 2019, time=2019-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1495779, encodeId=c2cd1495e79a2, content=<a href='/topic/show?id=904e11381c1' target=_blank style='color:#2F92EE;'>#Mcl-1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11381, encryptionId=904e11381c1, topicName=Mcl-1)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=59d29195732, createdName=wangtianj2010@, createdTime=Mon Sep 16 06:56:00 CST 2019, time=2019-09-16, status=1, ipAttribution=)]
    2019-09-16 wangtianj2010@

    #Mcl-1#

    0

Baidu
map
Baidu
map
Baidu
map