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Neurology:帕金森病与阻塞性睡眠呼吸暂停患者的认知功能降低!

2017-02-23 xing.T MedSci原创

由此可见,OSA与PD患者嗜睡和认知功能障碍有关,提示OSA可能是这些NMS的可逆因素。需要进一步的研究来评估OSA治疗可否改善PD患者的嗜睡和认知功能障碍。

近日,神经病学领域权威取杂志Neurology上发表了一篇研究文章,研究人员旨在评估帕金森病(PD)患者中阻塞性睡眠呼吸暂停(OSA)和包括认知功能障碍在内的非运动症状(NMS)之间的相关性。

研究人员从运动障碍诊所招募原发性PD患者,并进行整夜多导睡眠图检查。OSA被定义为呼吸暂停低通气指数(AHI)≥15/h。PD严重程度采用Hoehn & Yahr(H&Y)分级量表和运动障碍学会统一帕金森病评定量表(MDS-UPDRS)来进行评估。研究人员采用蒙特利尔认知评估(MoCA)、Epworth嗜睡量表(ESS)、疲劳严重程度量表、冷漠评分量表、Beck抑郁问卷、医院焦虑抑郁量表和PD睡眠量表来评估NMS。

研究人员分析了67例患者(61.2%为男性),平均年龄为64.4岁(SD为9.9)和运动MDS-UPDRS评分为21.9(12.6),所使用左旋多巴等效剂量(LED)为752.4(714.6)mg/天。47例患者发生OSA(61.6%,平均AHI为27.1/h,SD为20.2h),57例患者发生NMS(85%)。ESS和MoCA均与AHI相关(ESSβ=0.0670,P=0.031;MoCAβ=-0.0520,P=0.043,调整年龄、性别、体重指数、LED、和H&Y评分)。ESS与呼吸觉醒(β=0.1015,P=0.011)和间歇性低氧血症(β=0.1470,P=0.006)相关。MoCA呼吸觉醒呈负相关(β=-0.0596,P=0.049),但与间歇低氧血症无关。

由此可见,OSA与PD患者嗜睡和认知功能障碍有关,提示OSA可能是这些NMS的可逆因素。需要进一步的研究来评估OSA治疗可否改善PD患者的嗜睡和认知功能障碍。

原始出处:

Victoria P. Mery,et al. Reduced cognitive function in patients with Parkinson disease and obstructive sleep apnea. Neurology. http://dx.doi.org/10.1212/WNL.0000000000003738

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    2018-01-23 tomyang96
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    2018-02-06 yinhl1978
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