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2014 AHA/ACC指南对NSTE-ACS抗血小板治疗的推荐

2014-09-28 寒林 编译 中国医学论坛报

        2014年9月23日,美国心脏学会(AHA)/美国心脏病学会(ACC)非ST段抬高型急性冠脉综合征(NSTE-ACS)管理指南进行了更新,其中关于NSTE-ACS患者起始治疗抗血小板药物/抗凝药物的推荐是大家重点关注的部分,现摘译指南对接受早期侵入性治疗或缺血指导策略治疗的确诊或疑似NST

        2014年9月23日,美国心脏学会(AHA)/美国心脏病学会(ACC)非ST段抬高型急性冠脉综合征(NSTE-ACS)管理指南进行了更新,其中关于NSTE-ACS患者起始治疗抗血小板药物/抗凝药物的推荐是大家重点关注的部分,现摘译指南对接受早期侵入性治疗或缺血指导策略治疗的确诊或疑似NSTE-ACS患者抗血小板治疗部分的推荐与读者分享。

        Ⅰ级推荐:

        ① 起病后应尽快给予所有无禁忌证的NSTE-ACS患者非肠溶性阿司匹林咀嚼片(162 mg~325 mg),并以阿司匹林维持剂量(81 mg~162 mg)无限期使用。(Ⅰ A)

        ② 因超敏反应及胃肠道不耐受而不能应用阿司匹林的患者,应给予负荷剂量的氯吡格雷治疗,并继以每日维持剂量治疗。(ⅠB)

        ③ 对于接受早期侵入性或缺血指导策略治疗,且无禁忌证的患者,推荐应用P2Y12抑制剂(包括氯吡格雷和替格瑞洛)联合阿司匹林治疗12个月。其中氯吡格雷的用法为负荷剂量300~600 mg后以75 mg/d维持(ⅠB),替格瑞洛为负荷剂量180 mg后以90 mg bid维持(ⅠB)。

        Ⅱa级推荐:

        对于接受早期侵入性或缺血指导策略治疗且无禁忌证的患者,应用P2Y12抑制剂治疗时,优先选择替格瑞洛是合理的(Ⅱa,B)。

        Ⅱb级推荐:

        对于接受早期侵入性治疗及双联抗血小板治疗(DAPT)的中高危NSTE-ACS患者(如肌钙蛋白阳性),起始抗血小板治疗策略中应考虑应用糖蛋白Ⅱa/Ⅲb抑制剂,依替巴肽及替罗非班为优选(Ⅱb,B)。


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  2. [GetPortalCommentsPageByObjectIdResponse(id=1947576, encodeId=8373194e5761d, content=<a href='/topic/show?id=a0291309883' target=_blank style='color:#2F92EE;'>#NSTE-ACS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13098, encryptionId=a0291309883, topicName=NSTE-ACS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=198d2500149, createdName=12498bd5m16暂无昵称, createdTime=Wed May 06 18:18:00 CST 2015, time=2015-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1977494, encodeId=e33419e74948c, content=<a href='/topic/show?id=d9e5130962f' target=_blank style='color:#2F92EE;'>#NST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13096, encryptionId=d9e5130962f, topicName=NST)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=80c5136, createdName=drj2003, createdTime=Sat May 02 12:18:00 CST 2015, time=2015-05-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=13430, encodeId=8dad1343001, content=优先选择替格瑞洛,患者有窒息感的发生率, beContent=null, objectType=article, channel=null, level=null, likeNumber=117, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18fc1609458, createdName=2012GMxl, createdTime=Wed Dec 24 10:50:00 CST 2014, time=2014-12-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1267217, encodeId=b74d126e21725, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Tue Sep 30 00:18:00 CST 2014, time=2014-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1279067, encodeId=d98412e90670e, content=<a href='/topic/show?id=316d1882bc' target=_blank style='color:#2F92EE;'>#ACS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1882, encryptionId=316d1882bc, topicName=ACS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=102a153, createdName=yaanren, createdTime=Tue Sep 30 00:18:00 CST 2014, time=2014-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1324957, encodeId=2a54132495eaa, content=<a href='/topic/show?id=96c71804b7' target=_blank style='color:#2F92EE;'>#ACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1804, encryptionId=96c71804b7, topicName=ACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e452500029, createdName=12498568m50暂无昵称, createdTime=Tue Sep 30 00:18:00 CST 2014, time=2014-09-30, status=1, ipAttribution=)]
    2015-05-02 drj2003
  3. [GetPortalCommentsPageByObjectIdResponse(id=1947576, encodeId=8373194e5761d, content=<a href='/topic/show?id=a0291309883' target=_blank style='color:#2F92EE;'>#NSTE-ACS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13098, encryptionId=a0291309883, topicName=NSTE-ACS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=198d2500149, createdName=12498bd5m16暂无昵称, createdTime=Wed May 06 18:18:00 CST 2015, time=2015-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1977494, encodeId=e33419e74948c, content=<a href='/topic/show?id=d9e5130962f' target=_blank style='color:#2F92EE;'>#NST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13096, encryptionId=d9e5130962f, topicName=NST)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=80c5136, createdName=drj2003, createdTime=Sat May 02 12:18:00 CST 2015, time=2015-05-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=13430, encodeId=8dad1343001, content=优先选择替格瑞洛,患者有窒息感的发生率, beContent=null, objectType=article, channel=null, level=null, likeNumber=117, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18fc1609458, createdName=2012GMxl, createdTime=Wed Dec 24 10:50:00 CST 2014, time=2014-12-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1267217, encodeId=b74d126e21725, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Tue Sep 30 00:18:00 CST 2014, time=2014-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1279067, encodeId=d98412e90670e, content=<a href='/topic/show?id=316d1882bc' target=_blank style='color:#2F92EE;'>#ACS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1882, encryptionId=316d1882bc, topicName=ACS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=102a153, createdName=yaanren, createdTime=Tue Sep 30 00:18:00 CST 2014, time=2014-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1324957, encodeId=2a54132495eaa, content=<a href='/topic/show?id=96c71804b7' target=_blank style='color:#2F92EE;'>#ACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1804, encryptionId=96c71804b7, topicName=ACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e452500029, createdName=12498568m50暂无昵称, createdTime=Tue Sep 30 00:18:00 CST 2014, time=2014-09-30, status=1, ipAttribution=)]
    2014-12-24 2012GMxl

    优先选择替格瑞洛,患者有窒息感的发生率

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1947576, encodeId=8373194e5761d, content=<a href='/topic/show?id=a0291309883' target=_blank style='color:#2F92EE;'>#NSTE-ACS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13098, encryptionId=a0291309883, topicName=NSTE-ACS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=198d2500149, createdName=12498bd5m16暂无昵称, createdTime=Wed May 06 18:18:00 CST 2015, time=2015-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1977494, encodeId=e33419e74948c, content=<a href='/topic/show?id=d9e5130962f' target=_blank style='color:#2F92EE;'>#NST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13096, encryptionId=d9e5130962f, topicName=NST)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=80c5136, createdName=drj2003, createdTime=Sat May 02 12:18:00 CST 2015, time=2015-05-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=13430, encodeId=8dad1343001, content=优先选择替格瑞洛,患者有窒息感的发生率, beContent=null, objectType=article, channel=null, level=null, likeNumber=117, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18fc1609458, createdName=2012GMxl, createdTime=Wed Dec 24 10:50:00 CST 2014, time=2014-12-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1267217, encodeId=b74d126e21725, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Tue Sep 30 00:18:00 CST 2014, time=2014-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1279067, encodeId=d98412e90670e, content=<a href='/topic/show?id=316d1882bc' target=_blank style='color:#2F92EE;'>#ACS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1882, encryptionId=316d1882bc, topicName=ACS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=102a153, createdName=yaanren, createdTime=Tue Sep 30 00:18:00 CST 2014, time=2014-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1324957, encodeId=2a54132495eaa, content=<a href='/topic/show?id=96c71804b7' target=_blank style='color:#2F92EE;'>#ACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1804, encryptionId=96c71804b7, topicName=ACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e452500029, createdName=12498568m50暂无昵称, createdTime=Tue Sep 30 00:18:00 CST 2014, time=2014-09-30, status=1, ipAttribution=)]
    2014-09-30 zhaohui6731
  5. [GetPortalCommentsPageByObjectIdResponse(id=1947576, encodeId=8373194e5761d, content=<a href='/topic/show?id=a0291309883' target=_blank style='color:#2F92EE;'>#NSTE-ACS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13098, encryptionId=a0291309883, topicName=NSTE-ACS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=198d2500149, createdName=12498bd5m16暂无昵称, createdTime=Wed May 06 18:18:00 CST 2015, time=2015-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1977494, encodeId=e33419e74948c, content=<a href='/topic/show?id=d9e5130962f' target=_blank style='color:#2F92EE;'>#NST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13096, encryptionId=d9e5130962f, topicName=NST)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=80c5136, createdName=drj2003, createdTime=Sat May 02 12:18:00 CST 2015, time=2015-05-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=13430, encodeId=8dad1343001, content=优先选择替格瑞洛,患者有窒息感的发生率, beContent=null, objectType=article, channel=null, level=null, likeNumber=117, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18fc1609458, createdName=2012GMxl, createdTime=Wed Dec 24 10:50:00 CST 2014, time=2014-12-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1267217, encodeId=b74d126e21725, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Tue Sep 30 00:18:00 CST 2014, time=2014-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1279067, encodeId=d98412e90670e, content=<a href='/topic/show?id=316d1882bc' target=_blank style='color:#2F92EE;'>#ACS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1882, encryptionId=316d1882bc, topicName=ACS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=102a153, createdName=yaanren, createdTime=Tue Sep 30 00:18:00 CST 2014, time=2014-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1324957, encodeId=2a54132495eaa, content=<a href='/topic/show?id=96c71804b7' target=_blank style='color:#2F92EE;'>#ACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1804, encryptionId=96c71804b7, topicName=ACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e452500029, createdName=12498568m50暂无昵称, createdTime=Tue Sep 30 00:18:00 CST 2014, time=2014-09-30, status=1, ipAttribution=)]
    2014-09-30 yaanren
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