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Lancet Diabetes Endo：严重胰岛素缺乏、严重胰岛素抵抗、肥胖相关和年龄相关糖尿病

2018-12-29 佚名中国循环杂志

一说糖尿病，很多人会想到1型糖尿病和2型糖尿病，但当前是个讲究精准治疗的时代，两种分型似乎显得粗糙些。

一说糖尿病，很多人会想到1型糖尿病和2型糖尿病，但当前是个讲究精准治疗的时代，两种分型似乎显得粗糙些。

近日，北大人民医院纪立农团队对此进行了探究并重新分为4个亚型：严重胰岛素缺乏糖尿病（SIDD）、严重胰岛素抵抗糖尿病（SIRD）、中度肥胖相关糖尿病（MOD）和中度年龄相关糖尿病（MARD）。

图1 中美新诊糖尿病人群各亚型的临床特征

这一研究中，研究者就中美流行病学调查的新诊断糖尿病人群，通过人工智能中的聚类方法，以年龄、体重指数、血糖水平、胰岛素敏感性指数及胰岛细胞功能指数等5个维度进行了分型。

各亚型的主要临床特征在中美人群以及不同种族的人群中基本一致，并与原北欧人群的亚型特点相重合。

采用人工智能的tSNE可视化方法对样本进行三维投射，各亚群之间从图像上彼此独立，相应视频在LancetTV同期发表。

该研究迈出了中国人群的糖尿病精准分型及治疗的第一步。

原始出处：Zou X, Zhou X, Zhu Z, Ji L. Novel subgroups of patients with adult-onset diabetes in Chinese and US populations. Lancet Diabetes Endo. 2019 Jan;7(1):9-11.

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2019-11-21 howi

#Lancet#

68 0
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2019-01-30 lily1616

#年龄相关#

76 0
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2019-07-04 baoya

#胰岛#

72 0
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objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82311653708, createdName=医者仁心5538, createdTime=Sat Dec 29 21:16:44 CST 2018, time=2018-12-29, status=1, ipAttribution=)]
2019-10-21 ms5439512287675881

#BET#

73 0
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2019-06-26 木头人513

#Diabetes#

77 0
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objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82311653708, createdName=医者仁心5538, createdTime=Sat Dec 29 21:16:44 CST 2018, time=2018-12-29, status=1, ipAttribution=)]
2019-12-08 ms9608593228839890

#DIA#

68 0
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2018-12-31 kafei

学习了谢谢

106 0
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2018-12-30 惠映实验室

学习，谢谢分享。

107 0
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objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82311653708, createdName=医者仁心5538, createdTime=Sat Dec 29 21:16:44 CST 2018, time=2018-12-29, status=1, ipAttribution=)]
2018-12-29 misszhang

谢谢MedSci提供最新的资讯

77 0
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2018-12-29 医者仁心5538

学习了

107 0

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