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JACC:冠脉疾病严重程度和血运重建完整性对经导管主动脉瓣置换患者死亡率的预后影响

2017-07-21 xiangting MedSci原创

只有重度CAD与TAVR后死亡率升高相关。TAVR前更完整的血运重建可能减轻重度CAD和死亡率的关联。

这项研究旨在探讨冠脉疾病(CAD)对接受经导管主动脉瓣置换术(TAVR)患者死亡率的影响。

CAD在TAVR群体中很常见的。然而在这一人群中关于CAD及其治疗预后意义的数据仍存在矛盾。

研究人员在3个中心分析了1,270例严重主动脉瓣狭窄(AS)接受TAVR治疗的患者。使用针对多种预后变量调整的Cox比例风险比模型,分析了CAD严重程度(无CAD,非严重CAD [即SYNTAX评分(SS)<22],严重CAD [SS> 22])和血运重建完整性("合理"不完全血运重建[ICR] [即残留SS<8];ICR [残留SS> 8])与TAVR后全因死亡率的关联。

在1,270例患者中,817例(64%)无CAD,331例(26%)无重度CAD,122例(10%)有重度CAD。中位随访1.9年,311例(24.5%)患者死亡。重度CAD和ICR组的死亡率较高,但不是在非重度CAD或"合理的"ICR组vs.无 CAD组间。经多变量调整后,重度CAD(风险比:2.091; p = 0.017)和ICR(风险比:1.720; p = 0.031)与死亡率升高有关。

只有重度CAD与TAVR后死亡率升高相关。TAVR前更完整的血运重建可能减轻重度CAD和死亡率的关联。

原始出处:

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    2018-03-10 yxch48
  3. 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    2018-01-23 hbwxf
  4. 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  5. [GetPortalCommentsPageByObjectIdResponse(id=1983526, encodeId=1e821983526c3, content=<a href='/topic/show?id=628553048e3' target=_blank style='color:#2F92EE;'>#患者死亡#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53048, encryptionId=628553048e3, topicName=患者死亡)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Mon Dec 11 06:18:00 CST 2017, time=2017-12-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1742412, encodeId=58021e4241275, content=<a href='/topic/show?id=39cae96626f' target=_blank style='color:#2F92EE;'>#置换#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79662, encryptionId=39cae96626f, topicName=置换)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3a7c35056336, 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content=<a href='/topic/show?id=1dd6231822d' target=_blank style='color:#2F92EE;'>#主动脉瓣#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23182, encryptionId=1dd6231822d, topicName=主动脉瓣)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=dc4b2500077, createdName=hittouch, createdTime=Sun Jul 23 12:18:00 CST 2017, time=2017-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1415173, encodeId=f6ac14151e3ae, content=<a href='/topic/show?id=04812314540' target=_blank style='color:#2F92EE;'>#主动脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23145, encryptionId=04812314540, topicName=主动脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=77603112682, createdName=circumcision, createdTime=Sun Jul 23 12:18:00 CST 2017, 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  6. [GetPortalCommentsPageByObjectIdResponse(id=1983526, encodeId=1e821983526c3, content=<a href='/topic/show?id=628553048e3' target=_blank style='color:#2F92EE;'>#患者死亡#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53048, encryptionId=628553048e3, topicName=患者死亡)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Mon Dec 11 06:18:00 CST 2017, time=2017-12-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1742412, encodeId=58021e4241275, content=<a href='/topic/show?id=39cae96626f' target=_blank style='color:#2F92EE;'>#置换#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79662, encryptionId=39cae96626f, topicName=置换)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3a7c35056336, 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  7. 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  8. 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time=2017-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1510077, encodeId=c0ed15100e7e6, content=<a href='/topic/show?id=e9bce8254ef' target=_blank style='color:#2F92EE;'>#经导管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78254, encryptionId=e9bce8254ef, topicName=经导管)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=93e010191378, createdName=lsj631, createdTime=Sun Jul 23 12:18:00 CST 2017, time=2017-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1536505, encodeId=676915365054c, content=<a href='/topic/show?id=a894e826546' target=_blank style='color:#2F92EE;'>#经导管主动脉瓣置换#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78265, encryptionId=a894e826546, topicName=经导管主动脉瓣置换)], attachment=null, 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    2017-07-23 lsj631
  9. 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  10. 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EUR HEART J:5年的临床和超声心动图的研究结果表明经导管主动脉瓣移植(TAVI)自我扩张型人工瓣膜可用于治疗严重的主动脉瓣狭窄!

在现实生活中,有症状且主动脉瓣高度狭窄的患者进行瓣膜置换术手术风险很高,该研究的目的是评估经导管主动脉瓣移植(TAVI)自我扩张型人工瓣膜的安全性和有效性。

JAHA:平均主动脉压力梯度对左心室射血分数正常的严重主动脉瓣狭窄患者长期结局的影响!

由此可见,该研究结果表明,不论症状,MTPG(≥60mmHg)对左室射血分数正常的严重主动脉瓣狭窄患者的长期结局具有不良预后影响。

EUR HEART J:可重新定位和完全可回收主动脉瓣的安全性和有效性:RESPOND研究

RESPOND的结果证实了,在常规临床实践中使用Lotus瓣进行TAVI的安全性和有效性。

EUR HEART J:使用全新一代气囊可膨胀心脏瓣膜,经导管主动脉瓣移植后的1年结果

使用最新一代气囊可膨胀心脏瓣膜,经导管主动脉瓣移植后的1年结果

JACC:经导管主动脉瓣置换的手术经验及其与结局的关联

在美国引入TAVR进入临床的初始阶段显示,经验增加与更好的结局相关。

JACC:经导管主动脉瓣置换术后阿司匹林与阿司匹林加氯吡格雷抗血栓治疗的比较

这项小型试验显示,SAPT(vs.DAPT)能减少TAVR后主要不良事件的发生。

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