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J Nutr Biochem：叶酸可抑制结肠直肠癌细胞迁移

2019-08-28 不详 网络

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我们最近发现，叶酸（FA）可以降低体外结肠癌细胞的增殖率，减小体内COLO-205肿瘤的体积。由于癌细胞增殖和迁移是癌症发展过程中的两个主要事件，我们进一步检查了FA是否也会影响结肠直肠癌细胞的迁移。Transwell侵袭实验证明，FA降低了结肠直肠癌细胞系COLO-205，LoVo和HT-29的侵袭能力。使用COLO-205作为细胞模型，我们进一步描绘了FA抑制的结肠直肠癌细胞侵袭的分子机制。蛋

我们最近发现，叶酸（FA）可以降低体外结肠癌细胞的增殖率，减小体内COLO-205肿瘤的体积。由于癌细胞增殖和迁移是癌症发展过程中的两个主要事件，我们进一步检查了FA是否也会影响结肠直肠癌细胞的迁移。

Transwell侵袭实验证明，FA降低了结肠直肠癌细胞系COLO-205，LoVo和HT-29的侵袭能力。使用COLO-205作为细胞模型，我们进一步描绘了FA抑制的结肠直肠癌细胞侵袭的分子机制。蛋白质印迹分析显示FA（10μM）激活丝氨酸10（Ser10）的cSrc，ERK1/2，NFκB和p27，并上调p53，p27和KIS蛋白。亚细胞分离说明FA处理增加了p27的胞质转运，p27-RhoA复合物的形成和RhoA降解。通过阻断cSrc或ERK1/2活性，使用siRNA技术敲低p27或KIS，或组成型活性RhoA cDNA的过表达，消除了FA诱导的COLO-205迁移抑制。

我们的结果表明FA通过cSrc/ERK1/2/NFκB/ p53通路上调p27。在细胞核中，FA上调KIS，这反过来增加了丝氨酸10（Ser10）的p27磷酸化，随后导致p27的细胞溶质转位并形成p27-RhoA复合物，从而导致RhoA降解，并最终抑制COLO-205细胞迁移。与我们之前的研究结果一起表明，FA通过抑制结肠直肠癌细胞增殖和迁移来减少结肠直肠癌的发展。

原始出处：

Ting PC, Lee WR, et al., Folic acid inhibits colorectal cancer cell migration. J Nutr Biochem. 2019 Jan;63:157-164. doi: 10.1016/j.jnutbio.2018.09.020. Epub 2018 Oct 6.

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    2020-01-22 ms8888626721583891

    #迁移#

    0

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    2019-09-11 sunylz

    #Bio#

    0

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    2019-08-30 yxch36

    #癌细胞#

    0

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    2019-08-30 amy0554

    #细胞迁移#

    0

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    2019-08-30 lmm403

    #结肠直肠癌#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1640978, encodeId=578216409e866, content=<a href='/topic/show?id=7c99939e3fd' target=_blank style='color:#2F92EE;'>#迁移#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93973, encryptionId=7c99939e3fd, topicName=迁移)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d37c22750496, createdName=ms8888626721583891, createdTime=Wed Jan 22 16:48:00 CST 2020, time=2020-01-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1918827, encodeId=5d8a191882e9c, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Wed Sep 11 20:48:00 CST 2019, time=2019-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1252633, encodeId=f21c12526330f, content=<a href='/topic/show?id=3efee1519b2' target=_blank style='color:#2F92EE;'>#癌细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71519, encryptionId=3efee1519b2, topicName=癌细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4cea26, createdName=yxch36, createdTime=Fri Aug 30 13:48:00 CST 2019, time=2019-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1529591, encodeId=a89d15295913a, content=<a href='/topic/show?id=6264e80409d' target=_blank style='color:#2F92EE;'>#细胞迁移#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78040, encryptionId=6264e80409d, topicName=细胞迁移)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7d5e11955593, createdName=amy0554, createdTime=Fri Aug 30 13:48:00 CST 2019, time=2019-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1586948, encodeId=3b301586948a4, content=<a href='/topic/show?id=a8fae87846b' target=_blank style='color:#2F92EE;'>#结肠直肠癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78784, encryptionId=a8fae87846b, topicName=结肠直肠癌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=87c517396713, createdName=lmm403, createdTime=Fri Aug 30 13:48:00 CST 2019, time=2019-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=371979, encodeId=fb493e197956, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82311653708, createdName=医者仁心5538, createdTime=Thu Aug 29 20:57:59 CST 2019, time=2019-08-29, status=1, ipAttribution=)]
    2019-08-29 医者仁心5538

    学习了

    0

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