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Cell Death & Disease:UBAC2通过BCRC-3/miRNA-182-5p/p27途径促进膀胱癌增殖

2020-09-25 AlexYang MedSci原创

新的证据表明,泛素相关结构域蛋白2 (UBAC2)与恶性肿瘤的发生发展密切相关。然而,UBAC2在膀胱癌(BC)发展中的功能和潜在的分子机制尚未明确。

新的证据表明,泛素相关结构域蛋白2 (UBAC2)与恶性肿瘤的发生发展密切相关。然而,UBAC2在膀胱癌(BC)发展中的功能和潜在的分子机制尚未明确。

在本研究中,来自郑州大学附属第一医院和华中科技大学同济医学院的研究者们发现UBAC2的mRNA和蛋白水平在BC组织和细胞系中均有上调,而抑制UBAC2的表达在体内外均能抑制BC细胞的增殖。同时,TCGA数据库中406例BC患者的Kaplan-Meier生存图显示,具有更高UBAC2表达的BC患者与更低的生存率相关。机制研究显示,UBAC2的下调通过转录后调控增加了p27的表达。他们前期的研究表明,环状RNA BCRC-3 (BCRC-3)通过与miR-182-5p相互作用促进了p27的表达,并逆转了miR-182-5p诱导的对p27 3'非编码区活性的抑制。在本研究中,他们发现UBAC2可以与BCRC-3结合,进而影响BCRC-3与miR-182-5p的相互作用,抑制p27的表达。此外,BCRC-3的下调部分逆转了UBAC2下调诱导的p27表达的上调。

体内和体外试验中,UABC2的敲除能够抑制BC细胞的增殖

该研究结果表明了UBAC2通过影响BCRC-3功能调控p27的新机制,为BC的诊断和治疗提供了研究依据。

原始出处:

Gu C., Zhao K., Zhou N. et al. UBAC2 promotes bladder cancer proliferation through BCRC-3/miRNA-182-5p/p27 axis. Cell Death Dis. Cell Death & Disease. 10 September 2020

 

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    2021-03-09 爆笑小医
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    2021-05-19 smallant2002
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    2020-11-23 yxch36
  6. [GetPortalCommentsPageByObjectIdResponse(id=1962291, encodeId=6c8e1962291a0, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Tue Mar 09 14:40:31 CST 2021, time=2021-03-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2013484, encodeId=6e4b2013484e1, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Thu May 27 03:40:31 CST 2021, time=2021-05-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1871990, encodeId=cf5718e1990d0, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Tue Jul 20 17:40:31 CST 2021, time=2021-07-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1930791, encodeId=e6d61930e91f1, content=<a href='/topic/show?id=22f61180211' target=_blank style='color:#2F92EE;'>#miR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11802, encryptionId=22f61180211, topicName=miR)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a27288, createdName=smallant2002, createdTime=Wed May 19 04:40:31 CST 2021, time=2021-05-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1827262, encodeId=0950182e262e1, content=<a href='/topic/show?id=52e95194b9' target=_blank style='color:#2F92EE;'>#CRC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5194, encryptionId=52e95194b9, topicName=CRC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4cea26, createdName=yxch36, createdTime=Mon Nov 23 12:40:31 CST 2020, time=2020-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1312375, encodeId=28ac13123e5b8, content=<a href='/topic/show?id=e5571193321' target=_blank style='color:#2F92EE;'>#miRNA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11933, encryptionId=e5571193321, topicName=miRNA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e87d405, createdName=Homburg, createdTime=Sun Sep 27 10:40:31 CST 2020, time=2020-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1531675, encodeId=538215316e518, content=<a href='/topic/show?id=770e5e9457' target=_blank style='color:#2F92EE;'>#Death#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5794, encryptionId=770e5e9457, topicName=Death)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=32e312278742, createdName=cy0328, createdTime=Sun Sep 27 10:40:31 CST 2020, time=2020-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1039992, encodeId=91c510399920c, content=膀胱癌真怪,明明是免疫敏感性肿瘤,为什么PD-1治疗效果不好呢?难道靶点不对?将来CD47会不会有效, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=留走人康, createdTime=Fri Sep 25 22:40:31 CST 2020, time=2020-09-25, status=1, ipAttribution=)]
    2020-09-27 Homburg
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    2020-09-27 cy0328
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    2020-09-25 留走人康

    膀胱癌真怪,明明是免疫敏感性肿瘤,为什么PD-1治疗效果不好呢?难道靶点不对?将来CD47会不会有效

    0

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