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Pediatr Infect Dis J:孕期抗逆转录病毒治疗与小于胎龄儿

2015-04-20 Mechront 译 MedSci原创

世界上每天大约有1500名儿童感染艾滋病毒,其中大部分是在母亲怀孕和分娩时被感染的新生胎儿。通常HIV孕妇可以使用抗逆转录病毒(ARV)治疗以最大限度的减少垂直传播风险。先前有研究报道孕期抗逆转录病毒(ARV)治疗和小于胎龄儿(SGA)间有着某种关系,但目前的报道均不能完全阐明该联系。因此Phiri K等人收集了田纳西州相关医学记录,纳入1994-2009年间HIV孕妇。根据诊断、ARV处方、CD

世界上每天大约有1500名儿童感染艾滋病毒,其中大部分是在母亲怀孕和分娩时被感染的新生胎儿。通常HIV孕妇可以使用抗逆转录病毒(ARV)治疗以最大限度的减少垂直传播风险。

先前有研究报道孕期抗逆转录病毒(ARV)治疗和小于胎龄儿(SGA)间有着某种关系,但目前的报道均不能完全阐明该联系。因此Phiri K等人收集了田纳西州相关医学记录,纳入1994-2009年间HIV孕妇。根据诊断、ARV处方、CD4计数、HIV RNA检测结果等评估孕妇HIV状态。通过logistic回归模型计算ARV治疗导致小于胎龄儿(SGA)和早产的风险。

该研究共纳入477名HIV孕妇,共计604次单胎妊娠。其中156 (26%)分娩小于胎龄儿(SGA)。研究结果显示,孕期使用抗逆转录病毒(ARV)治疗与小于胎龄儿(SGA)的发生无关(aOR=0.93; 95% CI, 0.56-1.56),同时与早产也无关(aOR =0.74; 95% CI, 0.42-1.32 )。研究结果还得出,孕早期使用蛋白酶抑制剂(PI)比孕期未使用该种药物的孕妇有更低的小于胎龄儿(SGA)风险(OR=0.54; 95% CI, 0.29-1.01)。

研究结果表明,对于该HIV孕妇,还没有发现孕期使用抗逆转录病毒(ARV)治疗会导致小于胎龄儿(SGA)的风险有增减。

原始出处:

Phiri K, Williams PL, Dugan KB, et al.Antiretroviral Therapy Use during Pregnancy and the Risk of Small-for-Gestational-Age Birth in a Medicaid Population.Pediatr Infect Dis J. 2015 .

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createdName=cmj8wellington, createdTime=Tue Mar 08 06:08:00 CST 2016, time=2016-03-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1747190, encodeId=c2951e4719027, content=<a href='/topic/show?id=832e93345c3' target=_blank style='color:#2F92EE;'>#转录#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93345, encryptionId=832e93345c3, topicName=转录)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=58df35929710, createdName=mjldent, createdTime=Wed Jun 10 04:08:00 CST 2015, time=2015-06-10, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=1637078, encodeId=ea38163e078dd, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Tue Mar 22 00:08:00 CST 2016, time=2016-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1740304, encodeId=9e7c1e40304a3, content=<a href='/topic/show?id=f9f383688d0' target=_blank style='color:#2F92EE;'>#胎龄#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83688, encryptionId=f9f383688d0, topicName=胎龄)], attachment=null, authenticateStatus=null, createdAvatar=null, 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createdName=cmj8wellington, createdTime=Tue Mar 08 06:08:00 CST 2016, time=2016-03-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1747190, encodeId=c2951e4719027, content=<a href='/topic/show?id=832e93345c3' target=_blank style='color:#2F92EE;'>#转录#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93345, encryptionId=832e93345c3, topicName=转录)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=58df35929710, createdName=mjldent, createdTime=Wed Jun 10 04:08:00 CST 2015, time=2015-06-10, status=1, ipAttribution=)]
    2016-01-28 feather89
  6. 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  7. 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    2015-06-10 mjldent

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降低HIV感染率,只有割包皮?

前言:世界卫生组织正不遗余力的呼吁、推广包皮环切以降低HIV感染率。面对HIV,人类知道的难道只有包皮环切手术吗?非洲大陆的莫桑比克已进入夏天,烈日下,一群少年打闹着排着队,在流动诊所的帐篷外等待着进行包皮环切手术(Circumcision)。15岁的Helio(赫利奥)正在队伍里和他的小伙伴们打着扑克。一年前,他的朋友死于HIV感染,才19岁。之后,惊恐的Helio央求祖父能让他做环切手术。

JAIDS:HIV感染者新希望,抗逆转录病毒治疗

近日旧金山加州大学新临床研究显示,与那些不使用兴奋剂的感染艾滋病毒的人相比,341名使用冰毒和可卡因的感染艾滋病毒的人通过抗逆转录病毒的方法治疗初步见效。 “艾滋病患者用抗逆转录病毒疗法常常遇到困难,部分原因由于医疗服务提供者的担忧,他们不能准确把握药物定向。来自本研究的发现表明,许多兴奋剂使用者能够准确把握抗逆转录病毒治疗方法,这样足以避免引起消极的临床后果。抗逆转录病毒疗法能引起一些较好

AIDS 2014:抗逆转录病毒药物疗法新近进展(MODERN试验)

葛兰素史克(GSK)和辉瑞(Pfizer)合资公司ViiV Healthcare 7月22日在澳大利亚墨尔本举行的第20届国际艾滋病大会上公布了III期MODERN研究48周结果的分析数据,该项研究在抗逆转录病毒药物初治(antiretroviral-naïve)HIV患者中开展,将maraviroc(MVC,马拉韦罗,商品名Celsentri/Selzentry,一种口服CCR5进入抑制剂)+达

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