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Heart:房缺修复治疗后房颤和卒中风险就降低了吗

2015-02-20 叶琳琳 译 MedSci原创

房间隔缺损(ASD)为临床上常见的先天性心脏畸形,常伴发出现心房纤颤、心房扑动等心律失常,带来血栓形成和卒中发作等严重并发症,研究指出房缺行修补治疗后房颤发生风险增高。为评估房间隔缺损(ASD)患者的房颤和卒中风险较普通人群是否有明显差异,以及房缺行修复后房颤和卒中风险变化情况,丹麦的一些研究者展开了这项对照研究,近日将研究发表在Heart杂志上 从1977年到2009年,研究者收集了丹麦境内被诊

房间隔缺损(ASD)为临床上常见的先天性心脏畸形,常伴发出现心房纤颤、心房扑动等心律失常,带来血栓形成和卒中发作等严重并发症,研究指出房缺行修补治疗后房颤发生风险增高。为评估房间隔缺损(ASD)患者的房颤和卒中风险较普通人群是否有明显差异,以及房缺行修复后房颤和卒中风险变化情况,丹麦的一些研究者展开了这项对照研究,近日将研究发表在Heart杂志上 从1977年到2009年,研究者收集了丹麦境内被诊断为房间隔缺损的1168名患者(>18 years)。研究者将房缺患者和正常对照组进行性别和年龄匹配,随后对房颤发生风险、卒中风险进行COX回归分析。此外,研究者统计了ASD患者行修复手术前后抗凝药物和抗心律失常药物使用情况以及卒中相关死亡率。 研究者对上述每个研究对象进行了时间为1到33年不等的随访,中位随访时间9.6年(1-33 年)。房缺患者修复手术后有较高的首次房颤发生风险(调整后HR 8.2;95% CI:6.6-10.2)。在介入封堵和手术封堵两种修复方式上,术后房颤的发生风险无统计学差异(HR 1.5,95% CI 0.6-3.5)。有房颤病史的ASD患者行修复手术后再次房

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    2015-02-24 orthoW

    不错的文章,学习了

    0

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    2015-02-22 午夜星河

    抗凝重要

    0

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    2015-02-22 zhaojie88
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