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Neurology:DTI可用于早期诊断卒中后视觉障碍

2016-06-29 phylis 译 MedSci原创

目的:研究者调查扩散张量成像(DTI)显示白质完整性指数是否可用为卒中后视觉系统逆行跨突触变性(RTD)的早期标志物。方法:研究者进行一项前瞻性纵向分析,12例突触后视觉通路的脑卒中患者,12脑卒中患者,和28例健康对照,DTI生物标记指标的健康敏感性。研究者比较组间的差异(1)视神经束的各向异性分数(FA不对称),(2)视力障碍视野的检测,及(3)FA不对称和视野的评估之间的关系。结果:与对照组

目的:研究者调查扩散张量成像(DTI)显示白质完整性指数是否可用为卒中后视觉系统逆行跨突触变性(RTD)的早期标志物。

方法:研究者进行一项前瞻性纵向分析,12例突触后视觉通路的脑卒中患者,12脑卒中患者,和28例健康对照,DTI生物标记指标的健康敏感性。研究者比较组间的差异(1)视神经束的各向异性分数(FA不对称),(2)视力障碍视野的检测,及(3)FA不对称和视野的评估之间的关系。

结果:与对照组相比,视觉通路病变的患者FA-不对称较高。从受伤时间开始,3个月时这些差异是明显的,在12个月没有显著地变化。视觉通路卒中者显示视野检查受损,对照组无视野受损。FA-不对称和3个月内视野检查显著相关性,在12个月仍有相关性。

结论:损伤时间3个月,DTI作为RTD的指标很明显。这是最早的RTD非侵入性检查的证据。
此外,这些检查与视觉障碍检查相关。DTI检查提供一个可重复的,非侵入性的,并且敏感的调查RTD及视觉障碍作用的方法。

原始出处:

Patel KR, Ramsey LE, et al. Early diffusion evidence of retrograde transsynaptic degeneration in the human visual system. Neurology. 2016 Jun 15.


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    2016-11-26 yinhl1978
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    2016-10-11 ylzr123

    赞一个!好文章拜读了,认真学习了。

    0

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  5. [GetPortalCommentsPageByObjectIdResponse(id=1999716, encodeId=96421999e16b1, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Sat Nov 26 14:33:00 CST 2016, time=2016-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1671248, encodeId=19b116e1248d7, content=<a href='/topic/show?id=9f4e360191a' target=_blank style='color:#2F92EE;'>#卒中后#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36019, encryptionId=9f4e360191a, topicName=卒中后)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ff7426824786, createdName=waiwai3039, createdTime=Thu Nov 24 16:33:00 CST 2016, time=2016-11-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=145991, encodeId=7dd51459913b, content=赞一个!好文章拜读了,认真学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Tue Oct 11 22:31:19 CST 2016, time=2016-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1661280, encodeId=43d9166128040, content=<a href='/topic/show?id=39c79088173' target=_blank style='color:#2F92EE;'>#视觉障碍#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90881, encryptionId=39c79088173, topicName=视觉障碍)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a4c25257079, createdName=12498484m54(暂无昵称), createdTime=Sat Jan 28 23:33:00 CST 2017, time=2017-01-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1889356, encodeId=f7341889356c5, content=<a href='/topic/show?id=0e8e630161' target=_blank style='color:#2F92EE;'>#DTI#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6301, encryptionId=0e8e630161, topicName=DTI)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ef84111, createdName=whlxd, createdTime=Thu Oct 06 20:33:00 CST 2016, time=2016-10-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1382640, encodeId=1a9713826402f, content=<a href='/topic/show?id=1f4e5946422' target=_blank style='color:#2F92EE;'>#早期诊断#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59464, encryptionId=1f4e5946422, topicName=早期诊断)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Fri Jul 01 13:33:00 CST 2016, time=2016-07-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1481060, encodeId=440e14810605b, content=<a href='/topic/show?id=c592908329c' target=_blank style='color:#2F92EE;'>#视觉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90832, encryptionId=c592908329c, topicName=视觉)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=adcf7732830, createdName=zywlvao, createdTime=Fri Jul 01 13:33:00 CST 2016, time=2016-07-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=91691, encodeId=0fe09169104, content=嘎嘎嘎,不错,高端, beContent=null, objectType=article, channel=null, level=null, likeNumber=128, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a6831717982, createdName=微分, createdTime=Fri Jul 01 09:48:00 CST 2016, time=2016-07-01, status=1, ipAttribution=)]
    2016-10-06 whlxd
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    2016-07-01 zywlvao
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    2016-07-01 微分

    嘎嘎嘎,不错,高端

    0

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