Baidu
map

AJHG:遗传拷贝数变异和睾丸癌风险直接相关

2012-08-09 T.Shen 生物谷

遗传机制在癌症的发展和进程中扮演着至关重要的作用,但是特定遗传突变引发的某种癌症的分子机制目前并不清楚,进一步说,任何癌症和名为拷贝数突变(CNVs)的遗传突变没有关系。如今,刊登在国际杂志The American Journal of Human Genetics 上的一篇文章揭示了CNVs和睾丸癌风险直接相关,CNVs和乳腺癌及结肠癌却没有关联。 一些癌症,诸如乳腺癌或者结肠癌是由上一代的突

遗传机制在癌症的发展和进程中扮演着至关重要的作用,但是特定遗传突变引发的某种癌症的分子机制目前并不清楚,进一步说,任何癌症和名为拷贝数突变(CNVs)的遗传突变没有关系。如今,刊登在国际杂志The American Journal of Human Genetics 上的一篇文章揭示了CNVs和睾丸癌风险直接相关,CNVs和乳腺癌及结肠癌却没有关联。

一些癌症,诸如乳腺癌或者结肠癌是由上一代的突变所遗传而来而引发的。然而大多数癌症,包括睾丸癌,确实单个发生的(散发的),睾丸癌并不因家族遗传而增加其发病率,许多睾丸癌是由于精子细胞中的遗传突变所引起,科学家将这种突变称之为de novo突变。

为了揭示de novo突变和癌症风险的相关性,研究者Kenneth和其同事寻找到了CNVs,CNVs是一个或者一个片段DNA的复制或者剔除,研究者发现在睾丸癌患者中这种CNVs数量有明显的提高。尽管这种CNVs和孤独症及心虚管疾病有关,此前并无报道说CNVs和癌症相关。

研究者表示,这种de novo的改变或许是某种情况的指示剂,可以降低生育率。尽管现在的疗法手段可以使得90%的睾丸癌患者生存时间更长以及提高其生育率,但是这种遗留下来的情况可以影响无后代的男性。研究者指出,这种de novo种系的疾病病因学的范畴或许并不适用于迟发的癌症患者中。这就可以部分解释研究者在成人开始发现乳腺癌和结肠癌病人中低频率de novo的事件了。

编译自:Genetic Copy-Number Variants and Cancer Risk

doi:10.1016/j.ajhg.2012.06.019
PMC:
PMID:

Rare De Novo Germline Copy-Number Variation in Testicular Cancer

Zsofia K. Stadler1, 7, Diane Esposito2, 7, Sohela Shah3, 7, Joseph Vijai1, 7, Boris Yamrom2, 7, Dan Levy2, Yoon-ha Lee2, Jude Kendall2, Anthony Leotta2, Michael Ronemus2, Nichole Hansen1, Kara Sarrel1, Rohini Rau-Murthy1, Kasmintan Schrader3, Noah Kauff1, Robert J. Klein3, Steven M. Lipkin4, Rajmohan Murali5, Mark Robson1, Joel Sheinfeld6, Darren Feldman1, George Bosl1, Larry Norton1, Michael Wigler2 and Kenneth Offit1, 3, ,

Although heritable factors are an important determinant of risk of early-onset cancer, the majority of these malignancies appear to occur sporadically without identifiable risk factors. Germline de novo copy-number variations (CNVs) have been observed in sporadic neurocognitive and cardiovascular disorders. We explored this mechanism in 382 genomes of 116 early-onset cancer case-parent trios and unaffected siblings. Unique de novo germline CNVs were not observed in 107 breast or colon cancer trios or controls but were indeed found in 7% of 43 testicular germ cell tumor trios; this percentage exceeds background CNV rates and suggests a rare de novo genetic paradigm for susceptibility to some human malignancies.

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (6)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=2019218, encodeId=be8c201921867, content=<a href='/topic/show?id=19305629924' target=_blank style='color:#2F92EE;'>#拷贝数变异#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56299, encryptionId=19305629924, topicName=拷贝数变异)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ae503, createdName=pps20019, createdTime=Tue Feb 05 10:09:00 CST 2013, time=2013-02-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2061338, encodeId=e95e2061338bb, content=<a href='/topic/show?id=e6e1e15509f' target=_blank style='color:#2F92EE;'>#癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71550, encryptionId=e6e1e15509f, topicName=癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d58a435, createdName=sjq027, createdTime=Wed Jul 24 13:09:00 CST 2013, time=2013-07-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1983894, encodeId=8743198389449, content=<a href='/topic/show?id=3a375629858' target=_blank style='color:#2F92EE;'>#拷贝数#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56298, encryptionId=3a375629858, topicName=拷贝数)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3eaf430, createdName=bsmagic9132, createdTime=Wed Sep 19 06:09:00 CST 2012, time=2012-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1958224, encodeId=186c19582242c, content=<a href='/topic/show?id=3b99951653a' target=_blank style='color:#2F92EE;'>#遗传拷贝数变异#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95165, encryptionId=3b99951653a, topicName=遗传拷贝数变异)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Mon Dec 03 01:09:00 CST 2012, time=2012-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1342256, encodeId=101c1342256f3, content=<a href='/topic/show?id=34cb381023e' target=_blank style='color:#2F92EE;'>#变异#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38102, encryptionId=34cb381023e, topicName=变异)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=78c32500188, createdName=12498dabm77暂无昵称, createdTime=Sat Aug 11 02:09:00 CST 2012, time=2012-08-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1368298, encodeId=6d43136829883, content=<a href='/topic/show?id=2fa7e3068b9' target=_blank style='color:#2F92EE;'>#睾丸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73068, encryptionId=2fa7e3068b9, topicName=睾丸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6976269, createdName=zhangph, createdTime=Sat Aug 11 02:09:00 CST 2012, time=2012-08-11, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=2019218, encodeId=be8c201921867, content=<a href='/topic/show?id=19305629924' target=_blank style='color:#2F92EE;'>#拷贝数变异#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56299, encryptionId=19305629924, topicName=拷贝数变异)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ae503, createdName=pps20019, createdTime=Tue Feb 05 10:09:00 CST 2013, time=2013-02-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2061338, encodeId=e95e2061338bb, content=<a href='/topic/show?id=e6e1e15509f' target=_blank style='color:#2F92EE;'>#癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71550, encryptionId=e6e1e15509f, topicName=癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d58a435, createdName=sjq027, createdTime=Wed Jul 24 13:09:00 CST 2013, time=2013-07-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1983894, encodeId=8743198389449, content=<a href='/topic/show?id=3a375629858' target=_blank style='color:#2F92EE;'>#拷贝数#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56298, encryptionId=3a375629858, topicName=拷贝数)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3eaf430, createdName=bsmagic9132, createdTime=Wed Sep 19 06:09:00 CST 2012, time=2012-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1958224, encodeId=186c19582242c, content=<a href='/topic/show?id=3b99951653a' target=_blank style='color:#2F92EE;'>#遗传拷贝数变异#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95165, encryptionId=3b99951653a, topicName=遗传拷贝数变异)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Mon Dec 03 01:09:00 CST 2012, time=2012-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1342256, encodeId=101c1342256f3, content=<a href='/topic/show?id=34cb381023e' target=_blank style='color:#2F92EE;'>#变异#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38102, encryptionId=34cb381023e, topicName=变异)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=78c32500188, createdName=12498dabm77暂无昵称, createdTime=Sat Aug 11 02:09:00 CST 2012, time=2012-08-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1368298, encodeId=6d43136829883, content=<a href='/topic/show?id=2fa7e3068b9' target=_blank style='color:#2F92EE;'>#睾丸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73068, encryptionId=2fa7e3068b9, topicName=睾丸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6976269, createdName=zhangph, createdTime=Sat Aug 11 02:09:00 CST 2012, time=2012-08-11, status=1, ipAttribution=)]
    2013-07-24 sjq027
  3. [GetPortalCommentsPageByObjectIdResponse(id=2019218, encodeId=be8c201921867, content=<a href='/topic/show?id=19305629924' target=_blank style='color:#2F92EE;'>#拷贝数变异#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56299, encryptionId=19305629924, topicName=拷贝数变异)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ae503, createdName=pps20019, createdTime=Tue Feb 05 10:09:00 CST 2013, time=2013-02-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2061338, encodeId=e95e2061338bb, content=<a href='/topic/show?id=e6e1e15509f' target=_blank style='color:#2F92EE;'>#癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71550, encryptionId=e6e1e15509f, topicName=癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d58a435, createdName=sjq027, createdTime=Wed Jul 24 13:09:00 CST 2013, time=2013-07-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1983894, encodeId=8743198389449, content=<a href='/topic/show?id=3a375629858' target=_blank style='color:#2F92EE;'>#拷贝数#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56298, encryptionId=3a375629858, topicName=拷贝数)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3eaf430, createdName=bsmagic9132, createdTime=Wed Sep 19 06:09:00 CST 2012, time=2012-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1958224, encodeId=186c19582242c, content=<a href='/topic/show?id=3b99951653a' target=_blank style='color:#2F92EE;'>#遗传拷贝数变异#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95165, encryptionId=3b99951653a, topicName=遗传拷贝数变异)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Mon Dec 03 01:09:00 CST 2012, time=2012-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1342256, encodeId=101c1342256f3, content=<a href='/topic/show?id=34cb381023e' target=_blank style='color:#2F92EE;'>#变异#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38102, encryptionId=34cb381023e, topicName=变异)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=78c32500188, createdName=12498dabm77暂无昵称, createdTime=Sat Aug 11 02:09:00 CST 2012, time=2012-08-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1368298, encodeId=6d43136829883, content=<a href='/topic/show?id=2fa7e3068b9' target=_blank style='color:#2F92EE;'>#睾丸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73068, encryptionId=2fa7e3068b9, topicName=睾丸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6976269, createdName=zhangph, createdTime=Sat Aug 11 02:09:00 CST 2012, time=2012-08-11, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=2019218, encodeId=be8c201921867, content=<a href='/topic/show?id=19305629924' target=_blank style='color:#2F92EE;'>#拷贝数变异#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56299, encryptionId=19305629924, topicName=拷贝数变异)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ae503, createdName=pps20019, createdTime=Tue Feb 05 10:09:00 CST 2013, time=2013-02-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2061338, encodeId=e95e2061338bb, content=<a href='/topic/show?id=e6e1e15509f' target=_blank style='color:#2F92EE;'>#癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71550, encryptionId=e6e1e15509f, topicName=癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d58a435, createdName=sjq027, createdTime=Wed Jul 24 13:09:00 CST 2013, time=2013-07-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1983894, encodeId=8743198389449, content=<a href='/topic/show?id=3a375629858' target=_blank style='color:#2F92EE;'>#拷贝数#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56298, encryptionId=3a375629858, topicName=拷贝数)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3eaf430, createdName=bsmagic9132, createdTime=Wed Sep 19 06:09:00 CST 2012, time=2012-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1958224, encodeId=186c19582242c, content=<a href='/topic/show?id=3b99951653a' target=_blank style='color:#2F92EE;'>#遗传拷贝数变异#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95165, encryptionId=3b99951653a, topicName=遗传拷贝数变异)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Mon Dec 03 01:09:00 CST 2012, time=2012-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1342256, encodeId=101c1342256f3, content=<a href='/topic/show?id=34cb381023e' target=_blank style='color:#2F92EE;'>#变异#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38102, encryptionId=34cb381023e, topicName=变异)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=78c32500188, createdName=12498dabm77暂无昵称, createdTime=Sat Aug 11 02:09:00 CST 2012, time=2012-08-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1368298, encodeId=6d43136829883, content=<a href='/topic/show?id=2fa7e3068b9' target=_blank style='color:#2F92EE;'>#睾丸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73068, encryptionId=2fa7e3068b9, topicName=睾丸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6976269, createdName=zhangph, createdTime=Sat Aug 11 02:09:00 CST 2012, time=2012-08-11, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=2019218, encodeId=be8c201921867, content=<a href='/topic/show?id=19305629924' target=_blank style='color:#2F92EE;'>#拷贝数变异#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56299, encryptionId=19305629924, topicName=拷贝数变异)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ae503, createdName=pps20019, createdTime=Tue Feb 05 10:09:00 CST 2013, time=2013-02-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2061338, encodeId=e95e2061338bb, content=<a href='/topic/show?id=e6e1e15509f' target=_blank style='color:#2F92EE;'>#癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71550, encryptionId=e6e1e15509f, topicName=癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d58a435, createdName=sjq027, createdTime=Wed Jul 24 13:09:00 CST 2013, time=2013-07-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1983894, encodeId=8743198389449, content=<a href='/topic/show?id=3a375629858' target=_blank style='color:#2F92EE;'>#拷贝数#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56298, encryptionId=3a375629858, topicName=拷贝数)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3eaf430, createdName=bsmagic9132, createdTime=Wed Sep 19 06:09:00 CST 2012, time=2012-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1958224, encodeId=186c19582242c, content=<a href='/topic/show?id=3b99951653a' target=_blank style='color:#2F92EE;'>#遗传拷贝数变异#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95165, encryptionId=3b99951653a, topicName=遗传拷贝数变异)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Mon Dec 03 01:09:00 CST 2012, time=2012-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1342256, encodeId=101c1342256f3, content=<a href='/topic/show?id=34cb381023e' target=_blank style='color:#2F92EE;'>#变异#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38102, encryptionId=34cb381023e, topicName=变异)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=78c32500188, createdName=12498dabm77暂无昵称, createdTime=Sat Aug 11 02:09:00 CST 2012, time=2012-08-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1368298, encodeId=6d43136829883, content=<a href='/topic/show?id=2fa7e3068b9' target=_blank style='color:#2F92EE;'>#睾丸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73068, encryptionId=2fa7e3068b9, topicName=睾丸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6976269, createdName=zhangph, createdTime=Sat Aug 11 02:09:00 CST 2012, time=2012-08-11, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=2019218, encodeId=be8c201921867, content=<a href='/topic/show?id=19305629924' target=_blank style='color:#2F92EE;'>#拷贝数变异#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56299, encryptionId=19305629924, topicName=拷贝数变异)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ae503, createdName=pps20019, createdTime=Tue Feb 05 10:09:00 CST 2013, time=2013-02-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2061338, encodeId=e95e2061338bb, content=<a href='/topic/show?id=e6e1e15509f' target=_blank style='color:#2F92EE;'>#癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71550, encryptionId=e6e1e15509f, topicName=癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d58a435, createdName=sjq027, createdTime=Wed Jul 24 13:09:00 CST 2013, time=2013-07-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1983894, encodeId=8743198389449, content=<a href='/topic/show?id=3a375629858' target=_blank style='color:#2F92EE;'>#拷贝数#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56298, encryptionId=3a375629858, topicName=拷贝数)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3eaf430, createdName=bsmagic9132, createdTime=Wed Sep 19 06:09:00 CST 2012, time=2012-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1958224, encodeId=186c19582242c, content=<a href='/topic/show?id=3b99951653a' target=_blank style='color:#2F92EE;'>#遗传拷贝数变异#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95165, encryptionId=3b99951653a, topicName=遗传拷贝数变异)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Mon Dec 03 01:09:00 CST 2012, time=2012-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1342256, encodeId=101c1342256f3, content=<a href='/topic/show?id=34cb381023e' target=_blank style='color:#2F92EE;'>#变异#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38102, encryptionId=34cb381023e, topicName=变异)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=78c32500188, createdName=12498dabm77暂无昵称, createdTime=Sat Aug 11 02:09:00 CST 2012, time=2012-08-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1368298, encodeId=6d43136829883, content=<a href='/topic/show?id=2fa7e3068b9' target=_blank style='color:#2F92EE;'>#睾丸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73068, encryptionId=2fa7e3068b9, topicName=睾丸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6976269, createdName=zhangph, createdTime=Sat Aug 11 02:09:00 CST 2012, time=2012-08-11, status=1, ipAttribution=)]
    2012-08-11 zhangph
Baidu
map
Baidu
map
Baidu
map