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Eur Heart J:减肥手术与心血管疾病

2022-03-05 MedSci原创 MedSci原创

当前的系统评价和荟萃分析表明,减肥手术与降低全因死亡率和心血管死亡率有关,并且降低了肥胖患者的几种心血管疾病发病率。因此,这些患者应考虑进行减肥手术。

肥胖症正迅速成为西方世界最大的医疗保健问题之一,并与发病率和死亡率相关。2016年,肥胖症导致400万人死亡。在美国,肥胖症[定义为体重指数(BMI)≥30kg/m2]在2015年成人中为40%,到2030年将上升到50%左右。肥胖是一个全球性的健康问题,与患者发病率和死亡率相关,通常是由心血管(CV)疾病引起的。虽然越来越多地在肥胖患者接受了减肥手术并降低了CV危险因素,但其对CV疾病的影响尚未确定。

近日,心血管领域权威杂志Eur Heart J上发表了一篇研究文章,根据系统评价和Meta分析指南的首选报告项目,研究人员进行了系统评价和Meta分析,以评估减肥手术对CV结局的影响。

研究人员检索了PubMed和Embase数据库,检索时间截至2021年8月,将减肥手术患者与非手术对照组进行了比较。感兴趣的结局是全因死亡率和心血管死亡率、心房颤动(AF)、心力衰竭(HF)、心肌梗死卒中

研究人员纳入了39项研究,均为前瞻性或回顾性队列研究,但没有随机试验。减肥手术对全因死亡[综合风险比(HR)为0.55;95%置信区间(CI)为0.49-0.62,P<0.001 vs. 对照组]和CV死亡率(HR为0.59,95%CI为0.47-0.73,P<0.001)有益。此外,减肥手术还与HF(HR为0.50,95%CI为0.38-0.66,P<0.001)、心肌梗死(HR为0.58,95%CI为0.43-0.76,P<0.001)和卒中发生率降低相关(HR为0.64,95%CI为0.53-0.77,P<0.001),而其与AF之间的关联无统计学意义(HR为0.82,95%CI为0.64-1.06,P=0.12)。

由此可见,当前的系统评价和荟萃分析表明,减肥手术与降低全因死亡率和心血管死亡率有关,并且降低了肥胖患者的几种心血管疾病发病率。因此,这些患者应考虑进行减肥手术。

原始出处:

Sophie L. van Veldhuisen,et al.Bariatric surgery and cardiovascular disease: a systematic review and meta-analysis.European Heart Journal.2022.https://academic.oup.com/eurheartj/advance-article/doi/10.1093/eurheartj/ehac071/6542137

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    2022-03-07 ms5000000518166734

    学习学习学习学习学习学习学习学习学习学习学习学习学习学习学习学习学习

    0

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    2022-03-07 zhaojie88
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    2022-03-07 slcumt
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    2022-03-06 坚定的心

    学习了

    0

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    2022-03-06 carrotlyl

    第一张配图是何……

    0

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    2022-03-05 ms2000001939126778

    学习学习

    0

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    2022-03-05 CHANGE

    什么时候有懒人用的减肥神药?

    0

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对于心血管疾病高风险的老年人而言,跑步或快走并不是降低心血管疾病风险的唯一方法。简单的日常生活运动,包括做家务、园艺、烹饪等等,都可以显著有益于心血管健康。

JAHA:心血管疾病患者的螯合疗法

重复使用EDTA治疗CVD可为糖尿病和严重外周动脉疾病患者带来更多益处。给药方案之间的差异,包括剂量、溶液成分和输液次数,限制了研究之间的比较。需要进一步的研究来证实这些结果并评估金属的潜在介导作用。

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