Baidu
map

Diabetologia:多学科讨论:喝酒真的能降低糖尿病风险吗?

2017-11-20 常路 环球医学

糖尿病已成为严重危害人类健康的疾病之一。饮酒量、频率、酒的种类都会影响其诱发糖尿病的几率。2017年10月,发表在《Diabetologia》的一项队列研究调查了普通丹麦男性和女性人群中饮酒模式和糖尿病风险之间的相关性。

糖尿病已成为严重危害人类健康的疾病之一。饮酒量、频率、酒的种类都会影响其诱发糖尿病的几率。2017年10月,发表在《Diabetologia》的一项队列研究调查了普通丹麦男性和女性人群中饮酒模式和糖尿病风险之间的相关性。请看本期多学科讨论组临床药师各抒己见为您梳理本文看点——

目的/假设:饮酒与糖尿病负相关,但是饮酒模式的作用知之甚少。研究人员在普通丹麦男性和女性人群中检测了饮酒模式和糖尿病风险之间的相关性。

方法:本队列研究基于丹麦健康检查调查2007~2008年的数据。调查的76484名参与者中,28704名男性和41847名女性符合研究标准。参与者中位随访4.9年。自我报告的调查问卷用于获取饮酒模式的信息,即饮酒频率、过度饮酒频率、葡萄酒、啤酒和烈酒的消耗,从中研究人员计算了饮品特异性和总的每周平均酒精摄入。糖尿病发病的信息从丹麦全国糖尿病注册中获取。Cox成比例风险模型用于评估HR及95%可信区间。

结果:随访期,859名男性和887名女性发生糖尿病。相对于不饮酒,男性中糖尿病最低风险发生在每周饮酒14杯(HR,0.57(95%CI,0.47~0.70)),女性发生在每周饮酒9杯(HR,0.42(95%CI,0.35~0.51))。调整了混杂因素和每周平均饮酒量后,与每周饮酒<1天相比,每周饮酒3~4天与男性(0.73(95%CI,0.59~0.94))和女性(0.68(95%CI,0.53~0.88))糖尿病风险的显着性降低相关。

结论:结果表明,饮酒频率与糖尿病风险相关,每周饮酒3~4天与最低的糖尿病风险相关,甚至考虑了每周平均饮酒量后也是如此。

多学科讨论记实

中国农业大学营养与食品安全硕士、科信食品与营养信息交流中心科学技术部主任阮光锋表示,该研究有很多漏洞。首先,这个研究使用的方法是队列研究,它属于观察研究的一种,得出的是相关性的结论,并不是因果关系。也就是说研究本身没有足够的证据表明,特定的饮酒方式可以减少患糖尿病的风险。其次,生活习惯的调查和糖尿病患病情况回访之间差了4年,这项研究无法说明,4年间人们的生活习惯是否发生了改变。而且,这个研究只观察了5年,而糖尿病的发生周期其实很长,可能在观察更长时间之后,糖尿病的发生率又会发生改变。

英国糖尿病(Diabetes UK)研究项目负责人Emily Burns博士说,人们需要谨慎,因为“定期饮酒对2型糖尿病风险的影响会因人而异”。虽然这项调查结果很有意思,但他们“不会建议人们把酒类看作是一种超出现有NHS标准的绿色饮品”。

的确,有不少研究发现,少量饮酒与糖尿病发生存在负相关性。但有关酒精与糖尿病关系的实验研究还很少,而且缺乏系统性,所以,科学界目前并不推荐或者鼓励糖尿病患者饮酒。对于糖尿病的治疗和防御工作,我们还需用更加科学、安全的方法。

原始出处:

Holst C, Becker U, Jrgensen ME, et al. Alcohol drinking patterns and risk of diabetes: a cohort study of 70,551 men and women from the general Danish population.Diabetologia. 2017 Oct;60(10):1941-1950. doi: 10.1007/s00125-017-4359-3. Epub 2017 Jul 27.

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (5)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1760350, encodeId=e0c11e603505a, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Fri Feb 16 02:17:00 CST 2018, time=2018-02-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1638202, encodeId=48d7163820262, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Sun Dec 31 14:17:00 CST 2017, time=2017-12-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=263658, encodeId=8d4d263658cd, content=学习了谢谢分享!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Thu Nov 23 15:54:20 CST 2017, time=2017-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1439899, encodeId=35731439899fa, content=<a href='/topic/show?id=35904318480' target=_blank style='color:#2F92EE;'>#多学科#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43184, encryptionId=35904318480, topicName=多学科)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Wed Nov 22 05:17:00 CST 2017, time=2017-11-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1519816, encodeId=0fe7151981633, content=<a href='/topic/show?id=506b401e129' target=_blank style='color:#2F92EE;'>#喝酒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=40171, encryptionId=506b401e129, topicName=喝酒)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cc8811296196, createdName=ymljack, createdTime=Wed Nov 22 05:17:00 CST 2017, time=2017-11-22, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=1760350, encodeId=e0c11e603505a, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Fri Feb 16 02:17:00 CST 2018, time=2018-02-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1638202, encodeId=48d7163820262, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Sun Dec 31 14:17:00 CST 2017, time=2017-12-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=263658, encodeId=8d4d263658cd, content=学习了谢谢分享!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Thu Nov 23 15:54:20 CST 2017, time=2017-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1439899, encodeId=35731439899fa, content=<a href='/topic/show?id=35904318480' target=_blank style='color:#2F92EE;'>#多学科#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43184, encryptionId=35904318480, topicName=多学科)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Wed Nov 22 05:17:00 CST 2017, time=2017-11-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1519816, encodeId=0fe7151981633, content=<a href='/topic/show?id=506b401e129' target=_blank style='color:#2F92EE;'>#喝酒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=40171, encryptionId=506b401e129, topicName=喝酒)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cc8811296196, createdName=ymljack, createdTime=Wed Nov 22 05:17:00 CST 2017, time=2017-11-22, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=1760350, encodeId=e0c11e603505a, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Fri Feb 16 02:17:00 CST 2018, time=2018-02-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1638202, encodeId=48d7163820262, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Sun Dec 31 14:17:00 CST 2017, time=2017-12-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=263658, encodeId=8d4d263658cd, content=学习了谢谢分享!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Thu Nov 23 15:54:20 CST 2017, time=2017-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1439899, encodeId=35731439899fa, content=<a href='/topic/show?id=35904318480' target=_blank style='color:#2F92EE;'>#多学科#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43184, encryptionId=35904318480, topicName=多学科)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Wed Nov 22 05:17:00 CST 2017, time=2017-11-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1519816, encodeId=0fe7151981633, content=<a href='/topic/show?id=506b401e129' target=_blank style='color:#2F92EE;'>#喝酒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=40171, encryptionId=506b401e129, topicName=喝酒)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cc8811296196, createdName=ymljack, createdTime=Wed Nov 22 05:17:00 CST 2017, time=2017-11-22, status=1, ipAttribution=)]
    2017-11-23 大爰

    学习了谢谢分享!!

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1760350, encodeId=e0c11e603505a, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Fri Feb 16 02:17:00 CST 2018, time=2018-02-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1638202, encodeId=48d7163820262, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Sun Dec 31 14:17:00 CST 2017, time=2017-12-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=263658, encodeId=8d4d263658cd, content=学习了谢谢分享!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Thu Nov 23 15:54:20 CST 2017, time=2017-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1439899, encodeId=35731439899fa, content=<a href='/topic/show?id=35904318480' target=_blank style='color:#2F92EE;'>#多学科#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43184, encryptionId=35904318480, topicName=多学科)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Wed Nov 22 05:17:00 CST 2017, time=2017-11-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1519816, encodeId=0fe7151981633, content=<a href='/topic/show?id=506b401e129' target=_blank style='color:#2F92EE;'>#喝酒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=40171, encryptionId=506b401e129, topicName=喝酒)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cc8811296196, createdName=ymljack, createdTime=Wed Nov 22 05:17:00 CST 2017, time=2017-11-22, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=1760350, encodeId=e0c11e603505a, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Fri Feb 16 02:17:00 CST 2018, time=2018-02-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1638202, encodeId=48d7163820262, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Sun Dec 31 14:17:00 CST 2017, time=2017-12-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=263658, encodeId=8d4d263658cd, content=学习了谢谢分享!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Thu Nov 23 15:54:20 CST 2017, time=2017-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1439899, encodeId=35731439899fa, content=<a href='/topic/show?id=35904318480' target=_blank style='color:#2F92EE;'>#多学科#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43184, encryptionId=35904318480, topicName=多学科)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Wed Nov 22 05:17:00 CST 2017, time=2017-11-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1519816, encodeId=0fe7151981633, content=<a href='/topic/show?id=506b401e129' target=_blank style='color:#2F92EE;'>#喝酒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=40171, encryptionId=506b401e129, topicName=喝酒)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cc8811296196, createdName=ymljack, createdTime=Wed Nov 22 05:17:00 CST 2017, time=2017-11-22, status=1, ipAttribution=)]
    2017-11-22 ymljack

相关资讯

一喝酒就全身通红,究竟为什么?

人的身体里有两种酶会对酒精产生作用,一种叫做乙醇脱氢酶(alcohol dehydrogenase),这种酶能够迅速将乙醇转化为乙醛,体内含有大量这种酶的人,往往能够在喝酒后很短的时间内出现脸红的症状。所以喝酒脸红的人意味着能迅速将乙醇转化成乙醛,也就是说有他们有高效的乙醇脱氢酶。

Clin Psychol Sci:“酒后乱性”抑真?亦假!

不管我们将喝酒作为不良行为的借口或只是认为我们喝醉以后变得更有趣,我们大多数人似乎都认为,喝醉以后,我们的人格就会发生翻天覆地的变化。然而,一项最新研究表明,事实并非如此。

每周喝酒三四次降低糖尿病风险?又有研究被误读

我国已成为世界糖尿病第一大国。数据显示,中国约有1.1亿名糖尿病患者,约占中国成年人总数的1/10。糖尿病人最担心的是吃什么,最关心的也是吃什么;担心的是吃什么会升高血糖,关心的是吃什么能降血糖。近日有媒体报道称:最新研究发现,每周饮酒3-4次,糖尿病的风险降低21%。这让很多糖友非常激动,甚至很多不喝酒的人也跃跃欲试。这个研究到底是怎么回事?喝酒真的能降低糖尿病风险吗?糖尿病到底能不能喝酒?这个

中国人适合喝白酒养生?

近日,微信朋友圈里一篇《科学家给出惊人答案:中国人为什么要喝白酒?》的文章,让中国的酒鬼们兴奋异常,尤其是文中“最新科学研究表明:中国人的体质更适合喝白酒”的观点,更是为酒鬼们增加了继续开怀畅饮杯中陈酿的理由。但是,这篇文章中的一系列说法究竟是否靠谱呢?

哪些人喝酒更容易得肝癌?

喝酒伤肝,这是谁都知道的事情,但更多人知道的是酒精性肝病(ALD)。临床上,ALD 是由于长期大量饮酒所致的慢性肝病,初期通常表现为脂肪肝,进而可发展成酒精性肝炎、酒精性肝纤维化和酒精性肝硬化,流行病学调查发现,我国成人酒精性肝病的患病率为 4%-6%。说到酒精性肝病,很多人并不在意,觉得反正不是癌,无所谓。可是,作为一名负责任的肿瘤科医生,我必须要提醒那些长期酗酒的人,也许你近期的检查只是酒精性

想提高外语能力?喝点小酒或许管用

曾经酒醉过的人都可以证明,酒精的确会影响人的大脑和动作,让那时的你无法思考、行动不便。而其中最受影响的应是大脑的“执行功能”这一系列过程,这一过程包括注意力、记忆回想(memory recall)、对行为是否适当的辨别能力以及抑制不适当行为的能力。按理来说,由于执行功能(executive functions)在较高层次的认知过程中处于重要地位,而讲外语又在该认知过程之中,酒精应该是会损害你讲外语

Baidu
map
Baidu
map
Baidu
map