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J Hypertens:从青春期到成年早期的肺功能对血管健康的分析!

2017-07-02 xing.T MedSci原创

由此可见,用力呼气容积变化与青少年期至青年期收缩压变化呈正相关,提示早期肺功能在收缩压发展中起重要作用。血管指数与肺功能及其变化无关。

血管和肺功能发育在生命过程中不断下降;两者都能预测心血管事件和死亡率,但很少有人知道它们是如何随时间发展的。近日,高血压领域权威杂志Journal of Hypertension上发表了一篇研究文章,研究人员在一个多种族队列研究中分析了它们支架的关系,来检测从少年到青年时期的肺功能是否会影响血管指数。

在2003年,DASH研究纳入了6643名11-13岁的儿童;10%的具有代表性的参与者组成样本(n=665)参与了预实验随访至2013年。研究人员收集了心理学、人体测量学、血压、肺功能指标;在参与者年龄为21-23岁时测定了主动脉脉搏波传导速度(PWV)和增强指数(AIx)。在全球倡议民族调整后,研究人员采用线性回归和广义估计统计模型评估了用力呼气容积Z分数(zFEV1)与血压、PWV和Aix之间的关系。

该研究共纳入了资料完整的488名参与者。在11-13岁时,SBP与zFEV1呈正相关(系数为1.90,95%可信区间为1.11-2.68,P<0.001);但在21-23岁时没有这种相关性。在调整年龄、性别、种族、腰围身高比、就业报告种族、吸烟、饮酒混合效应模型中,10年zFEV1增加与SBP升高相关(1.38,0.25-1.51,P<0.05),但与DBP变化无关。在充分调整的模型中,无论是PWV还是中央Aix均与11-13岁或21-23岁的zFEV1无关(P>0.05)。

由此可见,用力呼气容积变化与青少年期至青年期收缩压变化呈正相关,提示早期肺功能在收缩压发展中起重要作用。血管指数与肺功能及其变化无关。

原始出处:

Lu, Yao; Sooky.et al. Longitudinal study of the influence of lung function on vascular health from adolescence to early adulthood in a British multiethnic cohort.Journal of Hypertension. 2017. http://journals.lww.com/jhypertension/Abstract/publishahead/Longitudinal_study_of_the_influence_of_lung.97682.aspx

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    2017-09-14 feather89
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    2017-07-21 1e10c84am36(暂无匿称)

    文章不错,谢谢分享

    0

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    2017-07-14 1e10c84am36(暂无匿称)

    文章很好,拜读了

    0

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    2017-07-02 1e145228m78(暂无匿称)

    学习了,谢谢作者分享!

    0

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