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Brit J Surg:减肥手术在降低结直肠癌风险中的作用

2020-01-31 xing.T MedSci原创

由此可见,与不进行手术的肥胖患者相比,进行减肥手术的患者发生结直肠癌的风险降低了35%。

肥胖会增加多种合并症的风险,例如2型糖尿病、心血管疾病和大多数癌症,包括直肠癌。目前,有关肥胖手术对大肠癌发生率的保护作用的文献存在相互矛盾的结果。近日,外科疾病领域权威杂志British Journal of Surgery上发表了一篇研究文章,这项荟萃分析旨在探究减肥手术对肥胖个体患直肠癌风险的影响。

研究人员检索了Ovid Embase、Ovid MEDLINE、Cochrane CENTRAL和Web of Science数据库中的相关文献,检索到2018年12月底发表的文献,根据循证医学PICO(人群、干预、控制、结果)模型提取数据,并使用随机效应模型进行分析,以评估合并的相对风险(RR)及其95%的置信区间。研究的异质性使用Cochran的Q和I2统计量进行了检验和量化。研究人员采用Meta回归分析研究年份、区域、平均随访时间和样本量与RR之间的关系。

该荟萃分析共纳入了7篇文献,共计1213727名患者。RR的汇总估计为0.64(95%CI为0.42至0.98)。非对称性检验未发现明显的发表偏倚。荟萃回归显示样本量是统计学上具有显著性的因素(P=0.037),但发表年份、地区和平均随访时间均不显著。

由此可见,与不进行手术的肥胖患者相比,进行减肥手术的患者发生结直肠癌的风险降低了35%。

原始出处:

S. Almazeedi.et al.Role of bariatric surgery in reducing the risk of colorectal cancer: a meta‐analysis.British Journal of Surgery.2020.https://bjssjournals.onlinelibrary.wiley.com/doi/10.1002/bjs.11494

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    2020-01-31 CHANGE

    什么时候有懒人用的减肥神药?

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