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Semin Arthritis Rheu:成人Still病死亡率的种族差异

2019-12-11 xiangting MedSci原创

研究人员发现在这一全国AOSD住院患者样本中,院内死亡率存在明显差异。

成人Still病(AOSD)是一种罕见的自身炎症性疾病。关于健康社会决定因素对其预后的影响知之甚少。这项研究目标是描述美国AOSD住院患者的种族差异、发病率和死亡率。

使用ICD-9代码714.2在美国全国住院样本数据库(NIS)查找2009年至2013年住院的AOSD成年患者。NIS是美国最大的全额付费住院患者数据库,每年大约有800万条住院治疗数据。排除患其他自身免疫性疾病的患者。使用描述性统计方法总结了患者和医院的特征。进行了针对混杂因素的调查加权logistic回归模型研究主要结局:院内死亡率。

2009-13年间,有5,820AOSD患者入院,平均年龄为53.6岁(SE-0.61)。女性为3817名(65.6%),白人占56%,亚裔占3%。巨噬细胞活化综合征(1.7%)、弥散性血管内凝血(DIC-1.1%)和血栓性血小板减少性紫癜(0.4%)使住院治疗过程复杂化。研究期间有154例院内死亡(死亡率为2.6%)。院内死亡患者的平均年龄较大(62.4±3.1岁),亚裔占13.9%。与白人相比,亚裔患者的院内死亡率明显较高(aOR = 6.3995CI 1.77–23.1p = 0.005)。并发DIC患者的死亡率明显更高(aOR = 29.6995CI 5.5-160.41p = 0.006)。

研究人员发现在这一全国AOSD住院患者样本中,院内死亡率存在明显差异。

原始出处:

Bella Y.Mehta. Racial/Ethnic variations in morbidity and mortality in Adult Onset Still's Disease: An analysis of national dataset. Semin Arthritis Rheu. December 2019.

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