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Eur Heart J:体重指数正常的绝经后妇女区域体脂与心血管疾病风险的关系

2019-07-01 xing.T MedSci原创

由此可见,在BMI正常的绝经后妇女中,躯干脂肪增加和腿部脂肪减少都与CVD风险增加有关。

中心性肥胖与心血管疾病(CVD)风险增加有关,即使在体重指数(BMI)正常的人群中也是如此。近日,心血管领域权威杂志Eur Heart J上发表了一篇研究文章,研究人员旨在检验这一假设:BMI正常的绝经后妇女局部体脂沉积(躯干或腿部脂肪)与CVD风险改变有关。

研究人员纳入了2683名BMI正常(18.5-25 kg/m2)的绝经后妇女,她们参加了妇女健康倡议研究,并且在基线时没有已知的CVD。通过双能X射线吸收测定法测定身体组成成分。截至2017年2月确定了包括冠心病和卒中在内的CVD事件。

在中位随访17.9年期间,共发生了291例CVD事件。在调整人口统计学、生活方式和临床危险因素后,全身脂肪量和脂肪百分比都与CVD风险无关。较高的躯干脂肪百分比与CVD风险增加相关[最高与最低四分位风险比(HR)=1.91,95%置信区间(CI)为1.33-2.74; 趋势P<0.001],而腿部脂肪百分比较高与CVD风险降低相关(最高与最低四分位数HR=0.62,95%CI为0.43-0.89; 趋势P=0.008)。经过进一步调整腰围或腰臀比后,躯干脂肪的关联减弱但仍然显著。较高的躯干脂肪百分比和较低的腿部脂肪百分比与CVD特别高风险相关(最高与最低四分位数HR=3.33,95%CI为1.46-7.62)。 

由此可见,在BMI正常的绝经后妇女中,躯干脂肪增加和腿部脂肪减少都与CVD风险增加有关。  

原始出处:


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time=2019-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1563113, encodeId=9469156311322, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Wed Jul 03 11:39:00 CST 2019, time=2019-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1631615, encodeId=d2d91631615e2, content=<a href='/topic/show?id=6395e888343' target=_blank style='color:#2F92EE;'>#绝经后#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78883, encryptionId=6395e888343, topicName=绝经后)], attachment=null, 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    2019-07-03 zhaojie88
  5. 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  6. 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  7. 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  8. 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