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Ann Neurol:英国儿童动脉缺血性卒中预后和复发情况调查

2016-05-31 phylis 译 MedSci原创

背景:动脉缺血性卒中(AIS)是儿童获得性脑损伤的重要原因。一些有关儿童AIS基于人群的前瞻性研究已经完成。研究者旨在调查人群中儿童AIS事件发生后12个月后的结局。方法:纳入居住在南英格兰(人口599万的孩子)29天到16岁的孩子,这些孩子影像学检查确诊为AIS发生超过1年。应用儿科卒中预后测量量表(PSOM)进行家庭访问确定预后。应用儿童卒中复发和恢复量表(RRQ)评估父母对康复的印象。当家庭

背景:动脉缺血性卒中(AIS)是儿童获得性脑损伤的重要原因。一些有关儿童AIS基于人群的前瞻性研究已经完成。研究者旨在调查人群中儿童AIS事件发生后12个月后的结局。

方法:纳入居住在南英格兰(人口599万的孩子)29天到16岁的孩子,这些孩子影像学检查确诊为AIS发生超过1年。应用儿科卒中预后测量量表(PSOM)进行家庭访问确定预后。应用儿童卒中复发和恢复量表(RRQ)评估父母对康复的印象。当家庭访问不可行时,进行电话随访或临床随访获得PSOM得分。

结果:96例AIS的儿童。2名儿童失访。在随访12月之前,9 / 94(10%)儿童死亡。一个孩子AIS复发。随访中,78/85个孩子的PSOM得分可用。39 / 78(50%)有良好预后(总PSOM评分<1)和39 / 78(50%)有不良预后。癫痫发作与不良预后相关(OR 3.5,95% CI 1.16-10.6)。28 / 73(38%)的孩子被照顾者判断已经完全康复。10/84(12%)的孩子有反复发作癫痫和17 / 84(20%)孩子发生复发性头痛。

解释:AIS有死亡和长期神经功能缺陷的风险。然而,与以前英国的研究数据相比,此研究中患者死亡率,复发及神经功能损害显著较低。

原始出处:

Mallick AA, Ganesan V, et al. Outcome and recurrence one year after paediatric arterial ischaemic stroke in a population-based cohort. Ann Neurol. 2016 Mar 1.


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    2016-09-29 yinhl1978
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    2016-10-13 ylzr123

    好文,值得推荐。

    0

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