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Gut:亚洲胃癌贲门与非贲门肿瘤的全基因组关联分析

2016-09-24 MedSci MedSci原创

因此,研究结果表明单核苷酸多态性与胃癌的关联因肿瘤在胃中位置的不同显示出了一些不同的结果。提示通过检测相关单核苷酸多态性来推测胃部肿瘤的生长位置。

胃癌的全基因组关联分析(GWAS)已报道单核苷酸多态性(SNP)的差异与肿瘤亚型有关,特别是按照肿瘤长在贲门部还是非贲门部进行分类时。来自美国马里兰州国立卫生研究院癌症流行病学和遗传学系的Hu教授最近在消化病领域权威杂志《gut》上发表了胃癌贲门与非贲门肿瘤全基因组关联分析结果

研究纳入了东亚2350例胃癌病例,其中包括1189例胃底贲门部胃癌病例和1027例非贲门部胃癌病例,以及2708例正常对照。同时为了试验的可重复性,还从两个中国研究和一个韩国研究中纳入3042例贲门癌病例,4359例非贲门癌病例和7548例正常对照。从全基因组关联分析,研究者选取了每个胃癌亚型中前12SNP,总胃癌的前4SNP。研究者发现基因组在5p13.1PRKAA1 (rs10074991)在贲门癌(P=7.36×10−12)和非贲门癌(P=2.42×10−23)显著相关,每个等位基因联合终点的比值比为0.8095% 可信区间0.770.83)。在6p21.1rs2294693附近的UNC5CL与胃非贲门癌的风险显著相关(P=2.50×10−8),比值比为1.1895% 可信区间1.12~1.26),但是与贲门癌只是存在名义上的关联(P=1.47×10−2)。研究者还证实了先前报道的在MUC1上的rs4072037与总胃癌的关联(P=6.59×10-8),以及在贲门癌与非贲门癌也存在同样的关联。而先前报道的在PSCA上与与胃非贲门癌相关的三个SNP与贲门癌无明显关联。

因此,研究结果表明单核苷酸多态性与胃癌的关联因肿瘤在胃中位置的不同显示出了一些不同的结果。提示通过检测相关单核苷酸多态性来推测胃部肿瘤的生长位置。

原始出处: 

Nan Hu, et al. Genome-wide association study of gastric adenocarcinoma in Asia: a comparison of associations between cardia and non-cardia tumours. Gut. 2016.  doi:10.1136/gutjnl-2015-309340

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style='color:#2F92EE;'>#全基因组#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=29393, encryptionId=81eb2939373, topicName=全基因组)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=dc2113925052, createdName=ms1692810954239974, createdTime=Mon Sep 26 01:26:00 CST 2016, time=2016-09-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=134745, encodeId=fb64134e4564, content=加强医学基础研究非常必要。, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Sun Sep 25 07:37:00 CST 2016, time=2016-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=134330, 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    2017-06-15 gostraight
  2. 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    2016-10-01 jyzxjiangqin

    加强医学基础性研究。

    0

  3. 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style='color:#2F92EE;'>#全基因组#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=29393, encryptionId=81eb2939373, topicName=全基因组)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=dc2113925052, createdName=ms1692810954239974, createdTime=Mon Sep 26 01:26:00 CST 2016, time=2016-09-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=134745, encodeId=fb64134e4564, content=加强医学基础研究非常必要。, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Sun Sep 25 07:37:00 CST 2016, time=2016-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=134330, 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    2016-09-26 䖝二

    学习!

    0

  4. 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GetPortalCommentsPageByObjectIdResponse(id=134306, encodeId=37e51343061e, content=谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160811/IMG57AC91915ACA64463.jpg, createdBy=9c351934462, createdName=知难而进, createdTime=Sat Sep 24 12:54:00 CST 2016, time=2016-09-24, status=1, ipAttribution=)]
    2016-09-26 深海的鱼

    很好的研究了

    0

  5. 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GetPortalCommentsPageByObjectIdResponse(id=134306, encodeId=37e51343061e, content=谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160811/IMG57AC91915ACA64463.jpg, createdBy=9c351934462, createdName=知难而进, createdTime=Sat Sep 24 12:54:00 CST 2016, time=2016-09-24, status=1, ipAttribution=)]
    2016-09-25 jyzxjiangqin

    加强医学基础研究非常必要。

    0

  8. 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GetPortalCommentsPageByObjectIdResponse(id=134306, encodeId=37e51343061e, content=谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160811/IMG57AC91915ACA64463.jpg, createdBy=9c351934462, createdName=知难而进, createdTime=Sat Sep 24 12:54:00 CST 2016, time=2016-09-24, status=1, ipAttribution=)]
    2016-09-24 1dd8a7c5m95(暂无匿称)

    学习了,赞一个!!

    0

  9. 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GetPortalCommentsPageByObjectIdResponse(id=134306, encodeId=37e51343061e, content=谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160811/IMG57AC91915ACA64463.jpg, createdBy=9c351934462, createdName=知难而进, createdTime=Sat Sep 24 12:54:00 CST 2016, time=2016-09-24, status=1, ipAttribution=)]
    2016-09-24 知难而进

    继续关注!

    0

  10. 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    2016-09-24 知难而进

    谢谢分享!

    0

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JNCI:根治幽门螺杆菌可以降低胃癌风险

幽门螺杆菌与胃腺癌和胃黏膜相关淋巴组织(MALT)淋巴瘤风险的增加有关;幽门螺杆菌还与食管腺癌风险的降低有关。我们的目的是评估,根除治疗幽门螺杆菌后,对这些癌症风险的影响。 我们检索了PubMed、Web of Science、EMBASE和Cochrane图书馆等数据库,纳入探讨胃癌、MALT淋巴瘤或食管癌风险的研究(根治幽门螺杆菌 vs 不根治),合并后进行系统回顾和荟萃分析。 从

验尿筛查胃癌或能实现

由上海交大医学院附属瑞金医院教授朱正纲、于颖彦领衔的团队发现,尿液中可检测到胃癌标志物,预示着今后通过尿液也可筛查胃癌。相关成果日前发表于《癌症靶标》杂志。据悉,这项围绕胃癌患者尿液小分子标志物的创新性成果已申请国家发明专利。 由于尿液中的代谢物是小分子物质,原有的检测设备无法分析测试小分子化合物。瑞金医院研究人员从头摸索与建立分析方法,收集取样,并利用上海交大分析化学领域的精密仪器,对收

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胃癌是世界第三大癌症。在中国,每年有超过四十万病人受到胃癌的危害。对于局部晚期胃癌患者来说,目前手术彻底切除仍然是现有治疗方案的基石。胃癌在任何年龄均可发生,以50~60岁居多。胃癌具有起病隐匿、早期常因无明显症状而漏诊、易转移与复发和预后差等特点。胃癌的病因迄今尚未完全阐明。通过对胃癌发病的地理分布以及与移民关系的研究,一般认为外界环境和饮食因素与胃癌的发生关系最为密切,人体还有些利于胃癌发

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