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Int J Antimicrob Agents:多粘菌素B是镰孢菌属的克星?

2017-07-20 梁舒瑶 贾朝娟 环球医学

镰孢菌属是第三大最常导致侵袭性真菌感染的霉菌,但有效的抗菌药很少。2017年6月,发表在《Int J Antimicrob Agents》的一项研究显示,多粘霉素B(PMB)对所有的12种镰孢菌株均有杀菌作用。 镰孢菌属有许多种类,包括有尖孢镰刀菌、腐皮镰刀菌、谷镰孢霉和轮枝镰孢,会导致许多植物和人类感染。在临床实践中,镰孢菌是继曲霉菌和毛霉菌之后第三大最常导致侵袭性真菌感染的霉菌。但是,可用于

镰孢菌属是第三大最常导致侵袭性真菌感染的霉菌,但有效的抗菌药很少。2017年6月,发表在《Int J Antimicrob Agents》的一项研究显示,多粘霉素B(PMB)对所有的12种镰孢菌株均有杀菌作用。

镰孢菌属有许多种类,包括有尖孢镰刀菌、腐皮镰刀菌、谷镰孢霉和轮枝镰孢,会导致许多植物和人类感染。在临床实践中,镰孢菌是继曲霉菌和毛霉菌之后第三大最常导致侵袭性真菌感染的霉菌。但是,可用于治疗人类和植物镰孢菌感染的抗真菌药很少。阳离子多肽抗生素多粘霉素B(PMB)显示出抵抗人类真菌病原体白色念珠菌和新型隐球菌的抗真菌活性,但其抵抗镰孢菌的疗效还不清楚。

本研究考察了PMB对12种能感染人类和植物(香蕉、西红柿、甜瓜、豌豆、小麦和玉米)的镰孢菌株的抗真菌活性。

PMB对所有的12种镰孢菌株均有杀菌作用,大多数菌株的最小抑菌浓度是32?μg/mL或64?μg/mL,通过肉汤稀释法、美蓝染色法和XTT减少测试证实。PMB可减少分生孢子的发芽率,但不能减少厚垣孢子,并且可能造成镰孢菌素的细胞膜完整性发生缺陷。PMB与泊沙康唑具有协同作用,并且可能增强氟康唑、伏立康唑或两性霉素B抵抗镰孢菌的作用。但是,PMB对氟康唑抵抗镰孢菌没有协同作用,正如对白色念珠菌和新型隐球菌一样,这表明酶母病原体和丝状真菌镰孢菌之间的机制存在进化差异。

原始出处:

Hsu LH, Wang HF, et al. The antibiotic polymyxin B exhibits novel antifungal activity against Fusarium species. Int J Antimicrob Agents. 2017 Jun;49(6):740-748. doi: 10.1016/j.ijantimicag.2017.01.029.

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    2017-08-09 wjywjy
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    2018-05-02 xjy02
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    2017-08-19 grace5700
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    2017-07-20 131****1460

    学习了受益匪浅。

    0

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    2017-07-20 Chongyang Zhang

    签到学习了很多。

    0

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