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Breast Cancer Res Treat:乳腺癌患者将受益于抗阻运动训练

2016-07-24 Mechront 译 MedSci原创

目的:探究抗阻运动训练(RET)和有氧运动训练(AET) 对接受辅助化疗的乳腺癌(BC)患者的肌肉减少症、年龄相关肌肉力量损失、相关的生活质量(QoL)变化的影响。方法:化疗期间参与者被随机分为常规护理(UC)(n = 70)、AET(n = 64)和RET (n = 66)。测量患者肌肉减少症(骨骼肌肉指数 SMI)、年龄相关肌肉力量损失(上肢(UE) 和下肢(LE)肌肉功能障碍(MD))、相关

目的:探究抗阻运动训练(RET)和有氧运动训练(AET) 对接受辅助化疗的乳腺癌(BC)患者的肌肉减少症、年龄相关肌肉力量损失、相关的生活质量(QoL)变化的影响。

方法:化疗期间参与者被随机分为常规护理(UC)(n = 70)、AET(n = 64)和RET (n = 66)。测量患者肌肉减少症(骨骼肌肉指数 SMI)、年龄相关肌肉力量损失(上肢(UE) 和下肢(LE)肌肉功能障碍(MD))、相关的生活质量(QoL)变化(癌症治疗性贫血功能评估(FACT-An)量表)情况。

结果:在基线时,25.5 %的BC存在肌肉减少症,54.5 %存在肌肉力量损失,而这两个并发症均与更差的QoL有关。ANCOVAs显示RET优于UC:SMI (0.32 kg/m2; p = 0.017)、UE-MD (0.12 kg/kg; p < 0.001)、LE-MD (0.27 kg/kg; p < 0.001)。卡方分析显示,与UC/AET相比,RET存在显著效应:逆转肌肉减少症(p = 0.039)和肌肉力量损失(p = 0.019)。肌肉减少症的逆转与以下临床因素的改善有关:临床FACT-An(11.7 点[95 % CI -4.2 to 27.6])、贫血指数试验结果(Trial Outcome Index-Anemia)(10.0点[95 % CI -4.0 to 24.1])、疲劳(5.3点[95 % CI -1.5 to 12.1])。

结论:早期BC患者开始辅助化疗时,与更差的QoL相关的肌肉减少症和肌肉力量损失情况比预期的发生率更高。辅助化疗期间进行RET可以逆转这两种情况,但是只能逆转与QoL改善具有临床意义的相关肌肉减少症和肌肉力量损失。

原始出处:


Adams SC,et al.Impact of resistance and aerobic exercise on sarcopenia and dynapenia in breast cancer patients receiving adjuvant chemotherapy: a multicenter randomized controlled trial.Breast Cancer Res Treat. 2016 Jul 9. [Epub ahead of print]

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    2016-09-17 1e10c84am36(暂无匿称)

    不错哦,会学到很多,喜欢梅斯医学文章

    0

  4. 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createdBy=37bc15724202, createdName=hanhaisha2013, createdTime=Tue Jul 26 11:51:00 CST 2016, time=2016-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=94619, encodeId=b8ac9461979, content=讲的很全面, beContent=null, objectType=article, channel=null, level=null, likeNumber=154, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=a37a1710612, createdName=oo902, createdTime=Mon Jul 25 16:25:00 CST 2016, time=2016-07-25, status=1, ipAttribution=)]
    2016-09-10 1e10c84am36(暂无匿称)

    好文章,百姓也能从中学到好多医学知识

    0

  5. 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createdBy=37bc15724202, createdName=hanhaisha2013, createdTime=Tue Jul 26 11:51:00 CST 2016, time=2016-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=94619, encodeId=b8ac9461979, content=讲的很全面, beContent=null, objectType=article, channel=null, level=null, likeNumber=154, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=a37a1710612, createdName=oo902, createdTime=Mon Jul 25 16:25:00 CST 2016, time=2016-07-25, status=1, ipAttribution=)]
    2016-09-07 李东泽

    很好,不错,以后会多学习

    0

  6. 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  7. 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style='color:#2F92EE;'>#TREAT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17781, encryptionId=cf2a1e7818c, topicName=TREAT)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=606c2500035, createdName=ms3153534357578991, createdTime=Wed Aug 31 03:51:00 CST 2016, time=2016-08-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=107227, encodeId=af8810e227b0, content=好文,值得学习,赞!, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Tue Aug 30 10:35:00 CST 2016, time=2016-08-30, status=1, ipAttribution=), 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createdBy=37bc15724202, createdName=hanhaisha2013, createdTime=Tue Jul 26 11:51:00 CST 2016, time=2016-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=94619, encodeId=b8ac9461979, content=讲的很全面, beContent=null, objectType=article, channel=null, level=null, likeNumber=154, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=a37a1710612, createdName=oo902, createdTime=Mon Jul 25 16:25:00 CST 2016, time=2016-07-25, status=1, ipAttribution=)]
    2016-08-30 ylzr123

    好文,值得学习,赞!

    0

  8. 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style='color:#2F92EE;'>#TREAT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17781, encryptionId=cf2a1e7818c, topicName=TREAT)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=606c2500035, createdName=ms3153534357578991, createdTime=Wed Aug 31 03:51:00 CST 2016, time=2016-08-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=107227, encodeId=af8810e227b0, content=好文,值得学习,赞!, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Tue Aug 30 10:35:00 CST 2016, time=2016-08-30, status=1, ipAttribution=), 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createdBy=37bc15724202, createdName=hanhaisha2013, createdTime=Tue Jul 26 11:51:00 CST 2016, time=2016-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=94619, encodeId=b8ac9461979, content=讲的很全面, beContent=null, objectType=article, channel=null, level=null, likeNumber=154, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=a37a1710612, createdName=oo902, createdTime=Mon Jul 25 16:25:00 CST 2016, time=2016-07-25, status=1, ipAttribution=)]
    2016-07-26 zhaojie88
  9. 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createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Sat Sep 10 16:58:00 CST 2016, time=2016-09-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=113286, encodeId=ff8a11328631, content=很好,不错,以后会多学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Wed Sep 07 17:20:00 CST 2016, time=2016-09-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1796252, encodeId=89f41e9625281, content=<a href='/topic/show?id=cf2a1e7818c' target=_blank style='color:#2F92EE;'>#TREAT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17781, encryptionId=cf2a1e7818c, topicName=TREAT)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=606c2500035, createdName=ms3153534357578991, createdTime=Wed Aug 31 03:51:00 CST 2016, time=2016-08-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=107227, encodeId=af8810e227b0, content=好文,值得学习,赞!, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Tue Aug 30 10:35:00 CST 2016, time=2016-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1351085, encodeId=7a311351085f6, content=<a href='/topic/show?id=12e43e1263' target=_blank style='color:#2F92EE;'>#Breast#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3712, encryptionId=12e43e1263, topicName=Breast)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Tue Jul 26 11:51:00 CST 2016, time=2016-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1570998, encodeId=d36515e099862, content=<a href='/topic/show?id=f42823e48d7' target=_blank style='color:#2F92EE;'>#乳腺癌患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23748, encryptionId=f42823e48d7, topicName=乳腺癌患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=37bc15724202, createdName=hanhaisha2013, createdTime=Tue Jul 26 11:51:00 CST 2016, time=2016-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=94619, encodeId=b8ac9461979, content=讲的很全面, beContent=null, objectType=article, channel=null, level=null, likeNumber=154, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=a37a1710612, createdName=oo902, createdTime=Mon Jul 25 16:25:00 CST 2016, time=2016-07-25, status=1, ipAttribution=)]
    2016-07-25 oo902

    讲的很全面

    0

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