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NEJM:磁共振成像可增加前列腺癌检出率并减少“过度诊断”

2021-07-11 MedSci原创 MedSci原创

每年大约有 140 万男性被诊断出前列腺癌,375,000 人死于该疾病。先前有研究表明,早筛可以提早发现前列腺癌指证,从而降低前列腺癌死亡的风险。

每年大约有 140 万男性被诊断出前列腺癌,375,000 人死于该疾病。先前有研究表明,早筛可以提早发现前列腺癌指证,从而降低前列腺癌死亡的风险。然而,当前筛查策略前列腺特异性抗原(PSA)与传统活检相结合可能导致不必要的筛查。

CCO

近日,来自美国瑞典卡罗林斯卡医学院的研究人员利用最新数据重新评估前列腺癌筛查策略所导致的深远影响。研究结果显示,通过磁共振成像 (MRI) 和靶向活检进行筛查可能会将前列腺癌过度诊断减少一半。该研究结果发表在NEJM杂志上。

20世纪90年代初,PSA广泛应用于前列腺癌筛查,随之诊断出的前列腺癌患者迅速增加,同时死亡率在接下来的25年降低50%。然而,随着大量临床研究的积累,有关PSA相关利弊争论不休,导致人们不再积极接受筛查的主要原因。

在这项研究中,研究人员进行了一项基于人群的前列腺癌筛查非劣效试验,通过邮件邀请5074岁的普通人群参加。PSA水平为 3 ng/mL 或更高的参与者,以 2:3 的比例随机分配并接受标准活检(标准活检组)或接受 MRI如果MRI结果显示为前列腺癌,则进行靶向和标准活检(实验性活检组)。主要结局是在意向治疗人群中,诊断出有临床价值的癌症男性比例(Gleason评分≥7)。次要结果是检测到临床上无意义的癌症(Gleason评分为6分)。

研究结果显示,12750名男性中,PSA 水平为 3 ng/mL 或更高有1532名,并被随机分配接受活检:603 名被分配到标准活检组,929名被分配到实验活检组。实验活检组中有 192 名男性 (21%) 被诊断出具有临床意义的癌症,而标准活检组中有 106 名男性 (18%)。实验活检组中临床无意义癌症的百分比低于标准活检组(4% [41 名参与者] vs. 12% [73 名参与者];差异,-8 个百分点;95% CI-11 - 5)。

综上,以上结果表明,通过磁共振成像 (MRI) 和靶向活检替代传统的前列腺活检,可以将过度诊断减少一半。减少了不必要的活检数量和对轻微低风险肿瘤的识别,而新方法可以检测到同样多的临床肿瘤。鉴于筛查在肿瘤学上的益处,患者、医师和政策制定者需要权衡筛查的获益和危害。最大的危害可能是导致过度检出,以及之后的与治疗相关的长期不良反应。

原始出处

Martin Eklund et al, MRI-Targeted or Standard Biopsy in Prostate Cancer ScreeningNew England Journal of Medicine (2021). DOI: 10.1056/NEJMoa2100852

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    2021-09-17 沈敏

    通过磁共振成像 (MRI) 和靶向活检替代传统的前列腺活检,可以将过度诊断减少一半。

    0

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    2021-09-10 ms3000000161626604

    每年大约有 140 万男性被诊断出前列腺癌,375,000 人死于该疾病。先前有研究表明,早筛可以提早发现前列腺癌指证,从而降低前列腺癌死亡的风险。

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1052189, encodeId=177e1052189a9, content=通过磁共振成像 (MRI) 和靶向活检替代传统的前列腺活检,可以将过度诊断减少一半。, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=afe65591083, createdName=沈敏, createdTime=Fri Sep 17 06:08:56 CST 2021, time=2021-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1016306, encodeId=ce031016306cb, content=每年大约有 140 万男性被诊断出前列腺癌,375,000 人死于该疾病。先前有研究表明,早筛可以提早发现前列腺癌指证,从而降低前列腺癌死亡的风险。, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=afe65591083, createdName=ms3000000161626604, createdTime=Fri Sep 10 12:57:07 CST 2021, time=2021-09-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1014698, encodeId=d4eb101469875, content=签到, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=15405561066, createdName=学习无止境, createdTime=Sun Sep 05 08:18:40 CST 2021, time=2021-09-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1904822, encodeId=d68719048223d, content=<a href='/topic/show?id=ae97625036d' target=_blank style='color:#2F92EE;'>#检出率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62503, encryptionId=ae97625036d, topicName=检出率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ce68183, createdName=xiongke010, createdTime=Mon Mar 07 19:10:12 CST 2022, time=2022-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1341735, encodeId=68f11341e3504, content=<a href='/topic/show?id=24b8e37529a' target=_blank style='color:#2F92EE;'>#磁共振#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73752, encryptionId=24b8e37529a, topicName=磁共振)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=24a22500182, createdName=1696533704_45270454, createdTime=Tue Jul 13 06:10:12 CST 2021, time=2021-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=998563, encodeId=6bc9998563f9, content=<a href='/topic/show?id=3a59e376065' target=_blank style='color:#2F92EE;'>#磁共振成像#</a>可增加<a href='/topic/show?id=c8ee32526f3' target=_blank style='color:#2F92EE;'>#前列腺癌#</a>检出率,为什么又不是过度诊断?, beContent=null, objectType=article, channel=null, level=null, likeNumber=215, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73760, encryptionId=3a59e376065, topicName=磁共振成像), TopicDto(id=32526, encryptionId=c8ee32526f3, topicName=前列腺癌)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=张发宝, createdTime=Sun Jul 11 19:50:54 CST 2021, time=2021-07-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1035692, encodeId=b7a010356929d, content=顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Sun Jul 11 18:10:12 CST 2021, time=2021-07-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1041044, encodeId=6e681041044e9, content=前列腺癌相关研究,学习了,谢谢梅斯, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Sun Jul 11 18:10:12 CST 2021, time=2021-07-11, status=1, ipAttribution=)]
    2021-09-05 学习无止境

    签到

    0

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  5. [GetPortalCommentsPageByObjectIdResponse(id=1052189, encodeId=177e1052189a9, content=通过磁共振成像 (MRI) 和靶向活检替代传统的前列腺活检,可以将过度诊断减少一半。, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=afe65591083, createdName=沈敏, createdTime=Fri Sep 17 06:08:56 CST 2021, time=2021-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1016306, encodeId=ce031016306cb, content=每年大约有 140 万男性被诊断出前列腺癌,375,000 人死于该疾病。先前有研究表明,早筛可以提早发现前列腺癌指证,从而降低前列腺癌死亡的风险。, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=afe65591083, createdName=ms3000000161626604, createdTime=Fri Sep 10 12:57:07 CST 2021, time=2021-09-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1014698, encodeId=d4eb101469875, content=签到, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=15405561066, createdName=学习无止境, createdTime=Sun Sep 05 08:18:40 CST 2021, time=2021-09-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1904822, encodeId=d68719048223d, content=<a href='/topic/show?id=ae97625036d' target=_blank style='color:#2F92EE;'>#检出率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62503, encryptionId=ae97625036d, topicName=检出率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ce68183, createdName=xiongke010, createdTime=Mon Mar 07 19:10:12 CST 2022, time=2022-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1341735, encodeId=68f11341e3504, content=<a href='/topic/show?id=24b8e37529a' target=_blank style='color:#2F92EE;'>#磁共振#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73752, encryptionId=24b8e37529a, topicName=磁共振)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=24a22500182, createdName=1696533704_45270454, createdTime=Tue Jul 13 06:10:12 CST 2021, time=2021-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=998563, encodeId=6bc9998563f9, content=<a href='/topic/show?id=3a59e376065' target=_blank style='color:#2F92EE;'>#磁共振成像#</a>可增加<a href='/topic/show?id=c8ee32526f3' target=_blank style='color:#2F92EE;'>#前列腺癌#</a>检出率,为什么又不是过度诊断?, beContent=null, objectType=article, channel=null, level=null, likeNumber=215, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73760, encryptionId=3a59e376065, topicName=磁共振成像), TopicDto(id=32526, encryptionId=c8ee32526f3, topicName=前列腺癌)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=张发宝, createdTime=Sun Jul 11 19:50:54 CST 2021, time=2021-07-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1035692, encodeId=b7a010356929d, content=顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Sun Jul 11 18:10:12 CST 2021, time=2021-07-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1041044, encodeId=6e681041044e9, content=前列腺癌相关研究,学习了,谢谢梅斯, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Sun Jul 11 18:10:12 CST 2021, time=2021-07-11, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=1052189, encodeId=177e1052189a9, content=通过磁共振成像 (MRI) 和靶向活检替代传统的前列腺活检,可以将过度诊断减少一半。, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=afe65591083, createdName=沈敏, createdTime=Fri Sep 17 06:08:56 CST 2021, time=2021-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1016306, encodeId=ce031016306cb, content=每年大约有 140 万男性被诊断出前列腺癌,375,000 人死于该疾病。先前有研究表明,早筛可以提早发现前列腺癌指证,从而降低前列腺癌死亡的风险。, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=afe65591083, createdName=ms3000000161626604, createdTime=Fri Sep 10 12:57:07 CST 2021, time=2021-09-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1014698, encodeId=d4eb101469875, content=签到, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=15405561066, createdName=学习无止境, createdTime=Sun Sep 05 08:18:40 CST 2021, time=2021-09-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1904822, encodeId=d68719048223d, content=<a href='/topic/show?id=ae97625036d' target=_blank style='color:#2F92EE;'>#检出率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62503, encryptionId=ae97625036d, topicName=检出率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ce68183, createdName=xiongke010, createdTime=Mon Mar 07 19:10:12 CST 2022, time=2022-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1341735, encodeId=68f11341e3504, content=<a href='/topic/show?id=24b8e37529a' target=_blank style='color:#2F92EE;'>#磁共振#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73752, encryptionId=24b8e37529a, topicName=磁共振)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=24a22500182, createdName=1696533704_45270454, createdTime=Tue Jul 13 06:10:12 CST 2021, time=2021-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=998563, encodeId=6bc9998563f9, content=<a href='/topic/show?id=3a59e376065' target=_blank style='color:#2F92EE;'>#磁共振成像#</a>可增加<a href='/topic/show?id=c8ee32526f3' target=_blank style='color:#2F92EE;'>#前列腺癌#</a>检出率,为什么又不是过度诊断?, beContent=null, objectType=article, channel=null, level=null, likeNumber=215, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73760, encryptionId=3a59e376065, topicName=磁共振成像), TopicDto(id=32526, encryptionId=c8ee32526f3, topicName=前列腺癌)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=张发宝, createdTime=Sun Jul 11 19:50:54 CST 2021, time=2021-07-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1035692, encodeId=b7a010356929d, content=顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Sun Jul 11 18:10:12 CST 2021, time=2021-07-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1041044, encodeId=6e681041044e9, content=前列腺癌相关研究,学习了,谢谢梅斯, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Sun Jul 11 18:10:12 CST 2021, time=2021-07-11, status=1, ipAttribution=)]
    2021-07-11 张发宝

    #磁共振成像#可增加#前列腺癌#检出率,为什么又不是过度诊断?

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1052189, encodeId=177e1052189a9, content=通过磁共振成像 (MRI) 和靶向活检替代传统的前列腺活检,可以将过度诊断减少一半。, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=afe65591083, createdName=沈敏, createdTime=Fri Sep 17 06:08:56 CST 2021, time=2021-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1016306, encodeId=ce031016306cb, content=每年大约有 140 万男性被诊断出前列腺癌,375,000 人死于该疾病。先前有研究表明,早筛可以提早发现前列腺癌指证,从而降低前列腺癌死亡的风险。, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=afe65591083, createdName=ms3000000161626604, createdTime=Fri Sep 10 12:57:07 CST 2021, time=2021-09-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1014698, encodeId=d4eb101469875, content=签到, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=15405561066, createdName=学习无止境, createdTime=Sun Sep 05 08:18:40 CST 2021, time=2021-09-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1904822, encodeId=d68719048223d, content=<a href='/topic/show?id=ae97625036d' target=_blank style='color:#2F92EE;'>#检出率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62503, encryptionId=ae97625036d, topicName=检出率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ce68183, createdName=xiongke010, createdTime=Mon Mar 07 19:10:12 CST 2022, time=2022-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1341735, encodeId=68f11341e3504, content=<a href='/topic/show?id=24b8e37529a' target=_blank style='color:#2F92EE;'>#磁共振#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73752, encryptionId=24b8e37529a, topicName=磁共振)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=24a22500182, createdName=1696533704_45270454, createdTime=Tue Jul 13 06:10:12 CST 2021, time=2021-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=998563, encodeId=6bc9998563f9, content=<a href='/topic/show?id=3a59e376065' target=_blank style='color:#2F92EE;'>#磁共振成像#</a>可增加<a href='/topic/show?id=c8ee32526f3' target=_blank style='color:#2F92EE;'>#前列腺癌#</a>检出率,为什么又不是过度诊断?, beContent=null, objectType=article, channel=null, level=null, likeNumber=215, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73760, encryptionId=3a59e376065, topicName=磁共振成像), TopicDto(id=32526, encryptionId=c8ee32526f3, topicName=前列腺癌)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=张发宝, createdTime=Sun Jul 11 19:50:54 CST 2021, time=2021-07-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1035692, encodeId=b7a010356929d, content=顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Sun Jul 11 18:10:12 CST 2021, time=2021-07-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1041044, encodeId=6e681041044e9, content=前列腺癌相关研究,学习了,谢谢梅斯, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Sun Jul 11 18:10:12 CST 2021, time=2021-07-11, status=1, ipAttribution=)]
    2021-07-11 旺医

    顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1052189, encodeId=177e1052189a9, content=通过磁共振成像 (MRI) 和靶向活检替代传统的前列腺活检,可以将过度诊断减少一半。, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=afe65591083, createdName=沈敏, createdTime=Fri Sep 17 06:08:56 CST 2021, time=2021-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1016306, encodeId=ce031016306cb, content=每年大约有 140 万男性被诊断出前列腺癌,375,000 人死于该疾病。先前有研究表明,早筛可以提早发现前列腺癌指证,从而降低前列腺癌死亡的风险。, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=afe65591083, createdName=ms3000000161626604, createdTime=Fri Sep 10 12:57:07 CST 2021, time=2021-09-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1014698, encodeId=d4eb101469875, content=签到, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=15405561066, createdName=学习无止境, createdTime=Sun Sep 05 08:18:40 CST 2021, time=2021-09-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1904822, encodeId=d68719048223d, content=<a href='/topic/show?id=ae97625036d' target=_blank style='color:#2F92EE;'>#检出率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62503, encryptionId=ae97625036d, topicName=检出率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ce68183, createdName=xiongke010, createdTime=Mon Mar 07 19:10:12 CST 2022, time=2022-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1341735, encodeId=68f11341e3504, content=<a href='/topic/show?id=24b8e37529a' target=_blank style='color:#2F92EE;'>#磁共振#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73752, encryptionId=24b8e37529a, topicName=磁共振)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=24a22500182, createdName=1696533704_45270454, createdTime=Tue Jul 13 06:10:12 CST 2021, time=2021-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=998563, encodeId=6bc9998563f9, content=<a href='/topic/show?id=3a59e376065' target=_blank style='color:#2F92EE;'>#磁共振成像#</a>可增加<a href='/topic/show?id=c8ee32526f3' target=_blank style='color:#2F92EE;'>#前列腺癌#</a>检出率,为什么又不是过度诊断?, beContent=null, objectType=article, channel=null, level=null, likeNumber=215, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73760, encryptionId=3a59e376065, topicName=磁共振成像), TopicDto(id=32526, encryptionId=c8ee32526f3, topicName=前列腺癌)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=张发宝, createdTime=Sun Jul 11 19:50:54 CST 2021, time=2021-07-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1035692, encodeId=b7a010356929d, content=顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Sun Jul 11 18:10:12 CST 2021, time=2021-07-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1041044, encodeId=6e681041044e9, content=前列腺癌相关研究,学习了,谢谢梅斯, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Sun Jul 11 18:10:12 CST 2021, time=2021-07-11, status=1, ipAttribution=)]
    2021-07-11 misszhang

    前列腺癌相关研究,学习了,谢谢梅斯

    0

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