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Eur Respir J:心血管自主神经功能障碍标志可预测中年人慢性阻塞性肺病!

2018-03-09 xing.T MedSci原创

由此可见,中年人心血管自主神经功能障碍的细微征象可能先于COPD的发展。这种关联独立于心血管自主功能障碍与CAD之间的关系。

自主神经功能障碍常见于慢性阻塞性肺疾病(COPD),并且可能与已知的冠心病合并症有关。近日,呼吸疾病领域权威杂志Eur Respir J上发表了一篇研究文章,研究人员假设心血管自主神经功能障碍是预测人群中COPD患者的临床标记,独立于CAD。

在24768名人群为基础的队列中(平均年龄45岁),基线无气流阻塞,研究人员分析了一分钟立位收缩压(SBP)、舒张压(DBP)和静息心率变化与用力肺活量(FVC)、1秒钟用力呼气量(FEV1)之间的横截面关系。研究人员采用Cox回归模型分析了32年随访期间直立性SBP和DBP变化(SBP/DBP降低)与COPD之间的相关性。

基线直立性SBP下降(P=0.020)和DBP下降(P=0.001)与FVC减少相关,而静息心率与减少的FVC和FEV1相关(P<0.001)。对吸烟和基线肺功能进行调整后,SBP降低可预测COPD(每10mmHg的风险比(HR)为1.10,95%可信区间为1.03-1.18)。静息心率可预测吸烟者COPD(每分钟增加10次心跳的HR为1.11,95%可信区间为1.05-1.18)。在没有CAD的受试者中结果相似。

由此可见,中年人心血管自主神经功能障碍的细微征象可能先于COPD的发展。这种关联独立于心血管自主功能障碍与CAD之间的关系。

原始出处:

Fabrizio Ricci,et al.Markers of cardiovascular autonomic dysfunction predict COPD in middle-aged subjects.Eur Respir J. 2018. http://erj.ersjournals.com/content/51/3/1702481

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    2018-09-08 tomyang96
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    2018-10-29 amy0559
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  5. 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  6. 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  7. 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GetPortalCommentsPageByObjectIdResponse(id=294506, encodeId=f9302945061b, content=好好文章学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K1RUfOKQohib4bXhDtxVgOA9VcKY1LUZkCOmr0v3WupxANz2ibibNHkdevtSruvrhyI29IjXdtvUV48/0, createdBy=6ff82057534, createdName=139****5926, createdTime=Fri Mar 09 10:58:19 CST 2018, time=2018-03-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=294501, encodeId=5cde29450128, content=谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/11/eb1f237032e0bf07b10833fc3722e645.jpg, createdBy=2fed2145219, createdName=紫迎馨, createdTime=Fri Mar 09 10:44:04 CST 2018, time=2018-03-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=294496, encodeId=f6a62944966a, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Fri Mar 09 10:18:33 CST 2018, time=2018-03-09, status=1, ipAttribution=)]
  8. [GetPortalCommentsPageByObjectIdResponse(id=1674671, encodeId=a31f16e4671e3, content=<a href='/topic/show?id=1085e4227b3' target=_blank style='color:#2F92EE;'>#神经功能障碍#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74227, encryptionId=1085e4227b3, topicName=神经功能障碍)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=02a927064964, createdName=songbq, createdTime=Thu Jan 17 06:39:00 CST 2019, time=2019-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1696806, encodeId=54f31696806fa, content=<a href='/topic/show?id=d2e99e651e4' target=_blank style='color:#2F92EE;'>#阻塞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97651, encryptionId=d2e99e651e4, topicName=阻塞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a23129903429, createdName=tomyang96, createdTime=Sat Sep 08 15:39:00 CST 2018, time=2018-09-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1671880, encodeId=e4c016e1880e1, content=<a href='/topic/show?id=58378220131' target=_blank style='color:#2F92EE;'>#肺病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82201, encryptionId=58378220131, topicName=肺病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2f0826868454, createdName=amy0559, createdTime=Mon Oct 29 02:39:00 CST 2018, time=2018-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1687138, encodeId=3a51168e1385c, content=<a href='/topic/show?id=d84f859e01b' target=_blank style='color:#2F92EE;'>#自主神经功能障碍#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85970, encryptionId=d84f859e01b, topicName=自主神经功能障碍)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=658d28322622, createdName=1249859em47(暂无昵称), createdTime=Mon Jul 09 17:39:00 CST 2018, time=2018-07-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1421149, encodeId=f3321421149ce, content=<a href='/topic/show?id=09d33294eb8' target=_blank style='color:#2F92EE;'>#功能障碍#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32947, encryptionId=09d33294eb8, topicName=功能障碍)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b3493649807, createdName=naiwu78, createdTime=Sun Mar 11 00:39:00 CST 2018, time=2018-03-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1422066, encodeId=fe7e1422066b4, content=<a href='/topic/show?id=e5f0e42224f' target=_blank style='color:#2F92EE;'>#神经功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74222, encryptionId=e5f0e42224f, topicName=神经功能)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=85503680375, createdName=lhlxtx, createdTime=Sun Mar 11 00:39:00 CST 2018, time=2018-03-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1574903, encodeId=7e1215e490344, content=<a href='/topic/show?id=4f432212e79' target=_blank style='color:#2F92EE;'>#中年人#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22127, encryptionId=4f432212e79, topicName=中年人)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0ffb16038617, createdName=yhj-time, createdTime=Sun Mar 11 00:39:00 CST 2018, time=2018-03-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=294506, encodeId=f9302945061b, content=好好文章学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K1RUfOKQohib4bXhDtxVgOA9VcKY1LUZkCOmr0v3WupxANz2ibibNHkdevtSruvrhyI29IjXdtvUV48/0, createdBy=6ff82057534, createdName=139****5926, createdTime=Fri Mar 09 10:58:19 CST 2018, time=2018-03-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=294501, encodeId=5cde29450128, content=谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/11/eb1f237032e0bf07b10833fc3722e645.jpg, createdBy=2fed2145219, createdName=紫迎馨, createdTime=Fri Mar 09 10:44:04 CST 2018, time=2018-03-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=294496, encodeId=f6a62944966a, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Fri Mar 09 10:18:33 CST 2018, time=2018-03-09, status=1, ipAttribution=)]
    2018-03-09 139****5926

    好好文章学习了

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1674671, encodeId=a31f16e4671e3, content=<a href='/topic/show?id=1085e4227b3' target=_blank style='color:#2F92EE;'>#神经功能障碍#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74227, encryptionId=1085e4227b3, topicName=神经功能障碍)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=02a927064964, createdName=songbq, createdTime=Thu Jan 17 06:39:00 CST 2019, time=2019-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1696806, encodeId=54f31696806fa, content=<a href='/topic/show?id=d2e99e651e4' target=_blank style='color:#2F92EE;'>#阻塞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97651, encryptionId=d2e99e651e4, topicName=阻塞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a23129903429, createdName=tomyang96, createdTime=Sat Sep 08 15:39:00 CST 2018, time=2018-09-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1671880, encodeId=e4c016e1880e1, content=<a href='/topic/show?id=58378220131' target=_blank style='color:#2F92EE;'>#肺病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82201, encryptionId=58378220131, topicName=肺病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2f0826868454, createdName=amy0559, createdTime=Mon Oct 29 02:39:00 CST 2018, time=2018-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1687138, encodeId=3a51168e1385c, content=<a href='/topic/show?id=d84f859e01b' target=_blank style='color:#2F92EE;'>#自主神经功能障碍#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85970, encryptionId=d84f859e01b, topicName=自主神经功能障碍)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=658d28322622, createdName=1249859em47(暂无昵称), createdTime=Mon Jul 09 17:39:00 CST 2018, time=2018-07-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1421149, encodeId=f3321421149ce, content=<a href='/topic/show?id=09d33294eb8' target=_blank style='color:#2F92EE;'>#功能障碍#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32947, encryptionId=09d33294eb8, topicName=功能障碍)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b3493649807, createdName=naiwu78, createdTime=Sun Mar 11 00:39:00 CST 2018, time=2018-03-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1422066, encodeId=fe7e1422066b4, content=<a href='/topic/show?id=e5f0e42224f' target=_blank style='color:#2F92EE;'>#神经功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74222, encryptionId=e5f0e42224f, topicName=神经功能)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=85503680375, createdName=lhlxtx, createdTime=Sun Mar 11 00:39:00 CST 2018, time=2018-03-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1574903, encodeId=7e1215e490344, content=<a href='/topic/show?id=4f432212e79' target=_blank style='color:#2F92EE;'>#中年人#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22127, encryptionId=4f432212e79, topicName=中年人)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0ffb16038617, createdName=yhj-time, createdTime=Sun Mar 11 00:39:00 CST 2018, time=2018-03-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=294506, encodeId=f9302945061b, content=好好文章学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K1RUfOKQohib4bXhDtxVgOA9VcKY1LUZkCOmr0v3WupxANz2ibibNHkdevtSruvrhyI29IjXdtvUV48/0, createdBy=6ff82057534, createdName=139****5926, createdTime=Fri Mar 09 10:58:19 CST 2018, time=2018-03-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=294501, encodeId=5cde29450128, content=谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/11/eb1f237032e0bf07b10833fc3722e645.jpg, createdBy=2fed2145219, createdName=紫迎馨, createdTime=Fri Mar 09 10:44:04 CST 2018, time=2018-03-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=294496, encodeId=f6a62944966a, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Fri Mar 09 10:18:33 CST 2018, time=2018-03-09, status=1, ipAttribution=)]
    2018-03-09 紫迎馨

    谢谢分享

    0

  10. [GetPortalCommentsPageByObjectIdResponse(id=1674671, encodeId=a31f16e4671e3, content=<a href='/topic/show?id=1085e4227b3' target=_blank style='color:#2F92EE;'>#神经功能障碍#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74227, encryptionId=1085e4227b3, topicName=神经功能障碍)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=02a927064964, createdName=songbq, createdTime=Thu Jan 17 06:39:00 CST 2019, time=2019-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1696806, encodeId=54f31696806fa, content=<a href='/topic/show?id=d2e99e651e4' target=_blank style='color:#2F92EE;'>#阻塞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97651, encryptionId=d2e99e651e4, topicName=阻塞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a23129903429, createdName=tomyang96, createdTime=Sat Sep 08 15:39:00 CST 2018, time=2018-09-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1671880, encodeId=e4c016e1880e1, content=<a href='/topic/show?id=58378220131' target=_blank style='color:#2F92EE;'>#肺病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82201, encryptionId=58378220131, topicName=肺病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2f0826868454, createdName=amy0559, createdTime=Mon Oct 29 02:39:00 CST 2018, time=2018-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1687138, encodeId=3a51168e1385c, content=<a href='/topic/show?id=d84f859e01b' target=_blank style='color:#2F92EE;'>#自主神经功能障碍#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85970, encryptionId=d84f859e01b, topicName=自主神经功能障碍)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=658d28322622, createdName=1249859em47(暂无昵称), createdTime=Mon Jul 09 17:39:00 CST 2018, time=2018-07-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1421149, encodeId=f3321421149ce, content=<a href='/topic/show?id=09d33294eb8' target=_blank style='color:#2F92EE;'>#功能障碍#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32947, encryptionId=09d33294eb8, topicName=功能障碍)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b3493649807, createdName=naiwu78, createdTime=Sun Mar 11 00:39:00 CST 2018, time=2018-03-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1422066, encodeId=fe7e1422066b4, content=<a href='/topic/show?id=e5f0e42224f' target=_blank style='color:#2F92EE;'>#神经功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74222, encryptionId=e5f0e42224f, topicName=神经功能)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=85503680375, createdName=lhlxtx, createdTime=Sun Mar 11 00:39:00 CST 2018, time=2018-03-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1574903, encodeId=7e1215e490344, content=<a href='/topic/show?id=4f432212e79' target=_blank style='color:#2F92EE;'>#中年人#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22127, encryptionId=4f432212e79, topicName=中年人)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0ffb16038617, createdName=yhj-time, createdTime=Sun Mar 11 00:39:00 CST 2018, time=2018-03-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=294506, encodeId=f9302945061b, content=好好文章学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K1RUfOKQohib4bXhDtxVgOA9VcKY1LUZkCOmr0v3WupxANz2ibibNHkdevtSruvrhyI29IjXdtvUV48/0, createdBy=6ff82057534, createdName=139****5926, createdTime=Fri Mar 09 10:58:19 CST 2018, time=2018-03-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=294501, encodeId=5cde29450128, content=谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/11/eb1f237032e0bf07b10833fc3722e645.jpg, createdBy=2fed2145219, createdName=紫迎馨, createdTime=Fri Mar 09 10:44:04 CST 2018, time=2018-03-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=294496, encodeId=f6a62944966a, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Fri Mar 09 10:18:33 CST 2018, time=2018-03-09, status=1, ipAttribution=)]
    2018-03-09 1ddf0692m34(暂无匿称)

    学习了.谢谢分享

    0

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