施一公实验室取得诺贝尔奖级成果

2015-08-21 徐文科学网

大家都知道真核生物的基因包含外显子和内含子两部分，转录后得到的亦是包含外显子和内含子的pre-mRNA，接下来要得到只含有外显子的成熟mRNA需要一个庞然大物的加工处理（图1），这个庞然大物被称为剪接小体。图片来源：百度经验　　剪接小体主要由五个核酸蛋白亚复合物组成，五者共同协调，将pre-mRNA变成mRNA。多年来，大家都想了解剪接背后的机制，但是苦于没有高

大家都知道真核生物的基因包含外显子和内含子两部分，转录后得到的亦是包含外显子和内含子的pre-mRNA，接下来要得到只含有外显子的成熟mRNA需要一个庞然大物的加工处理（图1），这个庞然大物被称为剪接小体。

图片来源：百度经验

剪接小体主要由五个核酸蛋白亚复合物组成，五者共同协调，将pre-mRNA变成mRNA。多年来，大家都想了解剪接背后的机制，但是苦于没有高分辨率的三维结构。此次，施一公实验室终于通过冷冻电镜获得酵母来源的3.6埃分辨率的剪接小体的结构（图2），在science杂志发表了两篇research articles，这项成果将极大地提高人们对剪接机制的理解。

图片来源：Sciencemag.org

DNA的复制、转录和翻译过程是体内最基本的生命活动，被称为中心法则。该过程已经有超过五项诺贝尔奖被颁发（包括RNA聚合酶的结构及工作机制，核糖体的结构及工作机制），剪接作为真核生物中心法则中必不可少的一个重要环节，得诺贝尔奖是一点儿也不夸张的。

有意思的是，施一公曾在自传里写到，自己九几年做博后时去看了好几个实验室，其中一个是后来因解析核糖体高分辨率结构而获得2009年诺贝尔化学奖的Thomas A. Steitz。当时Steitz想让施一公做核糖体结构，一公跟其他人聊了聊，听说博后得5-6年，就没去，去了另一个结构生物学高手实验室。在那里，只需要一年多一点，发了一篇nature后，施一公的博后导师就说一公可以出师了，于是他就成了普林斯顿大学的助理教授。但是我想无论是谁，当时放弃了核糖体但是后来知道别人做出来了，是有一点后悔或者其他感受的。不过，这次施一公终于可以开怀大笑了，我感觉。

原始出处：

Chuangye Yan, Jing Hang, Ruixue Wan, Min Huang, Catherine C. L. Wong, Yigong Shi.Structure of a yeast spliceosome at 3.6-angstrom resolution.Science.Aug 20, 2015.DOI: 10.1126/science.aac7629

Jing Hang, Ruixue Wan, Chuangye Yan, Yigong Shi.Structural basis of pre-mRNA splicing.Science.Aug 20, 2015.DOI: 10.1126/science.aac8159

版权声明：
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料，版权均属于梅斯医学所有。非经授权，任何媒体、网站或个人不得转载，授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章，或“梅斯号”自媒体发布的文章，仅系出于传递更多信息之目的，本站仅负责审核内容合规，其内容不代表本站立场，本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系，我们将立即进行删除处理。
在此留言

评论区 (7)

#插入话题

插入图片

[GetPortalCommentsPageByObjectIdResponse(id=35983, encodeId=72753598370, content=好牛, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=25b61624599, createdName=xykzfl, createdTime=Sun Aug 23 07:54:00 CST 2015, time=2015-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35967, encodeId=87733596e6d, content=不错，拜读了, beContent=null, objectType=article, channel=null, level=null, likeNumber=146, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d1ab1619415, createdName=lecoo, createdTime=Sun Aug 23 00:16:00 CST 2015, time=2015-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35949, encodeId=c693359495a, content=崇拜, beContent=null, objectType=article, channel=null, level=null, likeNumber=122, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=40251618559, createdName=2014lb3, createdTime=Sat Aug 22 10:14:00 CST 2015, time=2015-08-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35943, encodeId=6a3f359434e, content=大牛, beContent=null, objectType=article, channel=null, level=null, likeNumber=134, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIKlpu9buib1TxXRibfFuzYXHaLxQgfUpwzYwTMo8551BS40KVZNRDLWmAXSibjfnFm0QggOrCSWElfw/132, createdBy=95aa1617853, createdName=happy1, createdTime=Sat Aug 22 06:56:00 CST 2015, time=2015-08-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35939, encodeId=6c4a3593976, content=太厉害了！, beContent=null, objectType=article, channel=null, level=null, likeNumber=159, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20170803/IMG5982F7A3DBB3C1061.jpg, createdBy=0ba51605600, createdName=Jianghuiqin, createdTime=Sat Aug 22 00:05:00 CST 2015, time=2015-08-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35932, encodeId=8f9c35932b7, content=施公最近很火啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=9e0b1603164, createdName=lovejing, createdTime=Fri Aug 21 16:57:00 CST 2015, time=2015-08-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35930, encodeId=06b93593085, content=有一点夸张了吧！, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Fri Aug 21 16:06:00 CST 2015, time=2015-08-21, status=1, ipAttribution=)]
2015-08-23 xykzfl

好牛

39 0
[GetPortalCommentsPageByObjectIdResponse(id=35983, encodeId=72753598370, content=好牛, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=25b61624599, createdName=xykzfl, createdTime=Sun Aug 23 07:54:00 CST 2015, time=2015-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35967, encodeId=87733596e6d, content=不错，拜读了, beContent=null, objectType=article, channel=null, level=null, likeNumber=146, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d1ab1619415, createdName=lecoo, createdTime=Sun Aug 23 00:16:00 CST 2015, time=2015-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35949, encodeId=c693359495a, content=崇拜, beContent=null, objectType=article, channel=null, level=null, likeNumber=122, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=40251618559, createdName=2014lb3, createdTime=Sat Aug 22 10:14:00 CST 2015, time=2015-08-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35943, encodeId=6a3f359434e, content=大牛, beContent=null, objectType=article, channel=null, level=null, likeNumber=134, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIKlpu9buib1TxXRibfFuzYXHaLxQgfUpwzYwTMo8551BS40KVZNRDLWmAXSibjfnFm0QggOrCSWElfw/132, createdBy=95aa1617853, createdName=happy1, createdTime=Sat Aug 22 06:56:00 CST 2015, time=2015-08-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35939, encodeId=6c4a3593976, content=太厉害了！, beContent=null, objectType=article, channel=null, level=null, likeNumber=159, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20170803/IMG5982F7A3DBB3C1061.jpg, createdBy=0ba51605600, createdName=Jianghuiqin, createdTime=Sat Aug 22 00:05:00 CST 2015, time=2015-08-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35932, encodeId=8f9c35932b7, content=施公最近很火啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=9e0b1603164, createdName=lovejing, createdTime=Fri Aug 21 16:57:00 CST 2015, time=2015-08-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35930, encodeId=06b93593085, content=有一点夸张了吧！, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Fri Aug 21 16:06:00 CST 2015, time=2015-08-21, status=1, ipAttribution=)]
2015-08-23 lecoo

不错，拜读了

146 0
[GetPortalCommentsPageByObjectIdResponse(id=35983, encodeId=72753598370, content=好牛, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=25b61624599, createdName=xykzfl, createdTime=Sun Aug 23 07:54:00 CST 2015, time=2015-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35967, encodeId=87733596e6d, content=不错，拜读了, beContent=null, objectType=article, channel=null, level=null, likeNumber=146, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d1ab1619415, createdName=lecoo, createdTime=Sun Aug 23 00:16:00 CST 2015, time=2015-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35949, encodeId=c693359495a, content=崇拜, beContent=null, objectType=article, channel=null, level=null, likeNumber=122, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=40251618559, createdName=2014lb3, createdTime=Sat Aug 22 10:14:00 CST 2015, time=2015-08-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35943, encodeId=6a3f359434e, content=大牛, beContent=null, objectType=article, channel=null, level=null, likeNumber=134, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIKlpu9buib1TxXRibfFuzYXHaLxQgfUpwzYwTMo8551BS40KVZNRDLWmAXSibjfnFm0QggOrCSWElfw/132, createdBy=95aa1617853, createdName=happy1, createdTime=Sat Aug 22 06:56:00 CST 2015, time=2015-08-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35939, encodeId=6c4a3593976, content=太厉害了！, beContent=null, objectType=article, channel=null, level=null, likeNumber=159, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20170803/IMG5982F7A3DBB3C1061.jpg, createdBy=0ba51605600, createdName=Jianghuiqin, createdTime=Sat Aug 22 00:05:00 CST 2015, time=2015-08-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35932, encodeId=8f9c35932b7, content=施公最近很火啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=9e0b1603164, createdName=lovejing, createdTime=Fri Aug 21 16:57:00 CST 2015, time=2015-08-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35930, encodeId=06b93593085, content=有一点夸张了吧！, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Fri Aug 21 16:06:00 CST 2015, time=2015-08-21, status=1, ipAttribution=)]
2015-08-22 2014lb3

崇拜

122 0
[GetPortalCommentsPageByObjectIdResponse(id=35983, encodeId=72753598370, content=好牛, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=25b61624599, createdName=xykzfl, createdTime=Sun Aug 23 07:54:00 CST 2015, time=2015-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35967, encodeId=87733596e6d, content=不错，拜读了, beContent=null, objectType=article, channel=null, level=null, likeNumber=146, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d1ab1619415, createdName=lecoo, createdTime=Sun Aug 23 00:16:00 CST 2015, time=2015-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35949, encodeId=c693359495a, content=崇拜, beContent=null, objectType=article, channel=null, level=null, likeNumber=122, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=40251618559, createdName=2014lb3, createdTime=Sat Aug 22 10:14:00 CST 2015, time=2015-08-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35943, encodeId=6a3f359434e, content=大牛, beContent=null, objectType=article, channel=null, level=null, likeNumber=134, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIKlpu9buib1TxXRibfFuzYXHaLxQgfUpwzYwTMo8551BS40KVZNRDLWmAXSibjfnFm0QggOrCSWElfw/132, createdBy=95aa1617853, createdName=happy1, createdTime=Sat Aug 22 06:56:00 CST 2015, time=2015-08-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35939, encodeId=6c4a3593976, content=太厉害了！, beContent=null, objectType=article, channel=null, level=null, likeNumber=159, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20170803/IMG5982F7A3DBB3C1061.jpg, createdBy=0ba51605600, createdName=Jianghuiqin, createdTime=Sat Aug 22 00:05:00 CST 2015, time=2015-08-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35932, encodeId=8f9c35932b7, content=施公最近很火啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=9e0b1603164, createdName=lovejing, createdTime=Fri Aug 21 16:57:00 CST 2015, time=2015-08-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35930, encodeId=06b93593085, content=有一点夸张了吧！, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Fri Aug 21 16:06:00 CST 2015, time=2015-08-21, status=1, ipAttribution=)]
2015-08-22 happy1

大牛

134 0
[GetPortalCommentsPageByObjectIdResponse(id=35983, encodeId=72753598370, content=好牛, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=25b61624599, createdName=xykzfl, createdTime=Sun Aug 23 07:54:00 CST 2015, time=2015-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35967, encodeId=87733596e6d, content=不错，拜读了, beContent=null, objectType=article, channel=null, level=null, likeNumber=146, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d1ab1619415, createdName=lecoo, createdTime=Sun Aug 23 00:16:00 CST 2015, time=2015-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35949, encodeId=c693359495a, content=崇拜, beContent=null, objectType=article, channel=null, level=null, likeNumber=122, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=40251618559, createdName=2014lb3, createdTime=Sat Aug 22 10:14:00 CST 2015, time=2015-08-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35943, encodeId=6a3f359434e, content=大牛, beContent=null, objectType=article, channel=null, level=null, likeNumber=134, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIKlpu9buib1TxXRibfFuzYXHaLxQgfUpwzYwTMo8551BS40KVZNRDLWmAXSibjfnFm0QggOrCSWElfw/132, createdBy=95aa1617853, createdName=happy1, createdTime=Sat Aug 22 06:56:00 CST 2015, time=2015-08-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35939, encodeId=6c4a3593976, content=太厉害了！, beContent=null, objectType=article, channel=null, level=null, likeNumber=159, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20170803/IMG5982F7A3DBB3C1061.jpg, createdBy=0ba51605600, createdName=Jianghuiqin, createdTime=Sat Aug 22 00:05:00 CST 2015, time=2015-08-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35932, encodeId=8f9c35932b7, content=施公最近很火啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=9e0b1603164, createdName=lovejing, createdTime=Fri Aug 21 16:57:00 CST 2015, time=2015-08-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35930, encodeId=06b93593085, content=有一点夸张了吧！, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Fri Aug 21 16:06:00 CST 2015, time=2015-08-21, status=1, ipAttribution=)]
2015-08-22 Jianghuiqin

太厉害了！

159 0
[GetPortalCommentsPageByObjectIdResponse(id=35983, encodeId=72753598370, content=好牛, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=25b61624599, createdName=xykzfl, createdTime=Sun Aug 23 07:54:00 CST 2015, time=2015-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35967, encodeId=87733596e6d, content=不错，拜读了, beContent=null, objectType=article, channel=null, level=null, likeNumber=146, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d1ab1619415, createdName=lecoo, createdTime=Sun Aug 23 00:16:00 CST 2015, time=2015-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35949, encodeId=c693359495a, content=崇拜, beContent=null, objectType=article, channel=null, level=null, likeNumber=122, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=40251618559, createdName=2014lb3, createdTime=Sat Aug 22 10:14:00 CST 2015, time=2015-08-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35943, encodeId=6a3f359434e, content=大牛, beContent=null, objectType=article, channel=null, level=null, likeNumber=134, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIKlpu9buib1TxXRibfFuzYXHaLxQgfUpwzYwTMo8551BS40KVZNRDLWmAXSibjfnFm0QggOrCSWElfw/132, createdBy=95aa1617853, createdName=happy1, createdTime=Sat Aug 22 06:56:00 CST 2015, time=2015-08-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35939, encodeId=6c4a3593976, content=太厉害了！, beContent=null, objectType=article, channel=null, level=null, likeNumber=159, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20170803/IMG5982F7A3DBB3C1061.jpg, createdBy=0ba51605600, createdName=Jianghuiqin, createdTime=Sat Aug 22 00:05:00 CST 2015, time=2015-08-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35932, encodeId=8f9c35932b7, content=施公最近很火啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=9e0b1603164, createdName=lovejing, createdTime=Fri Aug 21 16:57:00 CST 2015, time=2015-08-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35930, encodeId=06b93593085, content=有一点夸张了吧！, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Fri Aug 21 16:06:00 CST 2015, time=2015-08-21, status=1, ipAttribution=)]
2015-08-21 lovejing

施公最近很火啊

108 0
[GetPortalCommentsPageByObjectIdResponse(id=35983, encodeId=72753598370, content=好牛, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=25b61624599, createdName=xykzfl, createdTime=Sun Aug 23 07:54:00 CST 2015, time=2015-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35967, encodeId=87733596e6d, content=不错，拜读了, beContent=null, objectType=article, channel=null, level=null, likeNumber=146, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d1ab1619415, createdName=lecoo, createdTime=Sun Aug 23 00:16:00 CST 2015, time=2015-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35949, encodeId=c693359495a, content=崇拜, beContent=null, objectType=article, channel=null, level=null, likeNumber=122, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=40251618559, createdName=2014lb3, createdTime=Sat Aug 22 10:14:00 CST 2015, time=2015-08-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35943, encodeId=6a3f359434e, content=大牛, beContent=null, objectType=article, channel=null, level=null, likeNumber=134, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIKlpu9buib1TxXRibfFuzYXHaLxQgfUpwzYwTMo8551BS40KVZNRDLWmAXSibjfnFm0QggOrCSWElfw/132, createdBy=95aa1617853, createdName=happy1, createdTime=Sat Aug 22 06:56:00 CST 2015, time=2015-08-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35939, encodeId=6c4a3593976, content=太厉害了！, beContent=null, objectType=article, channel=null, level=null, likeNumber=159, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20170803/IMG5982F7A3DBB3C1061.jpg, createdBy=0ba51605600, createdName=Jianghuiqin, createdTime=Sat Aug 22 00:05:00 CST 2015, time=2015-08-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35932, encodeId=8f9c35932b7, content=施公最近很火啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=9e0b1603164, createdName=lovejing, createdTime=Fri Aug 21 16:57:00 CST 2015, time=2015-08-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35930, encodeId=06b93593085, content=有一点夸张了吧！, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Fri Aug 21 16:06:00 CST 2015, time=2015-08-21, status=1, ipAttribution=)]
2015-08-21 lovetcm

有一点夸张了吧！

114 0

内科

外科

专科科室

热点

按科室浏览

临床工具

科研工具

其他工具

科研数智化

真实世界研究解决方案

数字化学术传播解决方案

其它

转化医学

施一公实验室取得诺贝尔奖级成果

相关资讯

科室

工具

服务