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Thorax：下呼吸道菌群在早期肺囊性纤维化中的作用

2017-03-11 xing.T MedSci原创

下呼吸道菌群肺囊性纤维化
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在患有囊肿性纤维化的婴幼儿中，下呼吸道菌群具有动态性。识别囊性纤维化细菌病原体的主要微生物与下呼吸道炎症反应增加有关，但是早期微生物多样性与6 岁时肺功能无关。

在囊性纤维化的婴幼儿中，下呼吸道感染和炎症与不良的呼吸结局有关。然而，下呼吸道菌群在早期肺囊性纤维化发病机制中的作用仍然不确定。近日，胸部疾病领域权威杂志Thorax上发表了一篇研究文章，研究人员旨在探讨囊性纤维化的婴幼儿随着时间推移下呼吸道的菌群的发展情况，并探讨儿童6岁时气道炎症和肺功能之间的关系。

新生儿筛查后被新诊断为囊性纤维化的婴幼儿进行了系列、半年度的支气管镜和支气管肺泡灌洗（BAL）操作。同时进行定量微生物培养和炎症标志物（白细胞介素8和中性粒细胞弹性蛋白酶）指标测量。对存储的BAL样本进行16S核糖体RNA基因测序。在从医疗记录中提取儿童6岁时的肺功能检查结果记录。

该研究共有95例BAL样品提供了16S核糖体RNA基因数据。这些样本都是从1.2-78.3月大小的48例儿童中收集的，27例被纳入纵向样本和13例年龄小于6个月。下呼吸道菌群变化具有多样性，但多样性随着年龄增大而减少。识别囊性纤维化细菌病原体的检测与减少微生物多样性以及更大程度的下呼吸道炎症有关。而儿童6岁时气道炎症和肺功能之间没有关联。

在患有囊肿性纤维化的婴幼儿中，下呼吸道菌群具有动态性。识别囊性纤维化细菌病原体的主要微生物与下呼吸道炎症反应增加有关，但是早期微生物多样性与6 岁时肺功能无关。


原始出处：

Katherine B Frayman,et al.The lower airway microbiota in early cystic fibrosis lung disease: a longitudinal analysis. Thorax.2017.http://dx.doi.org/10.1136/thoraxjnl-2016-209279.

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    2017-09-10 ms2694732865965676

    #肺囊性纤维化#

    0

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    2018-01-05 wolongzxh

    #囊性#

    0

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    2017-03-14 天涯183

    非常好的研究

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1992851, encodeId=5bd419928518d, content=<a href='/topic/show?id=dfc082096cd' target=_blank style='color:#2F92EE;'>#肺囊性纤维化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82096, encryptionId=dfc082096cd, topicName=肺囊性纤维化)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKQHWdlyPWPmuHjfEXicudmC0dJ6SN5PHzglbDHibXpT1VXF2fKDnTzl2Eib4Pf94p58cnSKA3ZfGdFQ/132, createdBy=c44f2500101, createdName=ms2694732865965676, createdTime=Sun Sep 10 09:37:00 CST 2017, time=2017-09-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1675833, encodeId=b80216e5833df, content=<a href='/topic/show?id=7395403e580' target=_blank style='color:#2F92EE;'>#囊性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=40375, encryptionId=7395403e580, topicName=囊性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=926927300775, createdName=wolongzxh, createdTime=Fri Jan 05 01:37:00 CST 2018, time=2018-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=179875, encodeId=13f61e9875e9, content=非常好的研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Tue Mar 14 19:05:00 CST 2017, time=2017-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=179475, encodeId=99941e9475f6, content=非常好的研究，学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=120, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Mon Mar 13 07:09:12 CST 2017, time=2017-03-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1282402, encodeId=527c12824028e, content=<a href='/topic/show?id=700239e0772' target=_blank style='color:#2F92EE;'>#呼吸道#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39707, encryptionId=700239e0772, topicName=呼吸道)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e94174, createdName=zhmscau, createdTime=Mon Mar 13 06:37:00 CST 2017, time=2017-03-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=179196, encodeId=a22a1e9196b3, content=然而，下呼吸道菌群在早期肺囊性纤维化发病机制中的作用仍然不确定。, beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM6DGOvNrRdcib3UmzMgpEQplCaQGBmjHytXQqvsuocO2uV2lOAaJibzDafJudKToVfU12LzwArHDb4TSrmU2hk5Qxzc6icoicBK3Dg/0, createdBy=a7901968505, createdName=明心见性, createdTime=Sat Mar 11 23:00:42 CST 2017, time=2017-03-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=179154, encodeId=91b31e91547b, content=囊性纤维化的婴幼儿中，下呼吸道感染和炎症与不良的呼吸结局有关。, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Pw2csslt7CukWiabqiblnQAXaDEiaxhu025c3P0XshccTrbvGWBjKvnHIxbK3vqa80P7WGIFuicCFet97TicrNKpgB3TdabxP1vMh/0, createdBy=28851960965, createdName=榄枷檬, createdTime=Sat Mar 11 17:02:07 CST 2017, time=2017-03-11, status=1, ipAttribution=)]
    2017-03-13 天涯183

    非常好的研究，学习了

    0

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    2017-03-13 zhmscau

    #呼吸道#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1992851, encodeId=5bd419928518d, content=<a href='/topic/show?id=dfc082096cd' target=_blank style='color:#2F92EE;'>#肺囊性纤维化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82096, encryptionId=dfc082096cd, topicName=肺囊性纤维化)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKQHWdlyPWPmuHjfEXicudmC0dJ6SN5PHzglbDHibXpT1VXF2fKDnTzl2Eib4Pf94p58cnSKA3ZfGdFQ/132, createdBy=c44f2500101, createdName=ms2694732865965676, createdTime=Sun Sep 10 09:37:00 CST 2017, time=2017-09-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1675833, encodeId=b80216e5833df, content=<a href='/topic/show?id=7395403e580' target=_blank style='color:#2F92EE;'>#囊性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=40375, encryptionId=7395403e580, topicName=囊性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=926927300775, createdName=wolongzxh, createdTime=Fri Jan 05 01:37:00 CST 2018, time=2018-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=179875, encodeId=13f61e9875e9, content=非常好的研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Tue Mar 14 19:05:00 CST 2017, time=2017-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=179475, encodeId=99941e9475f6, content=非常好的研究，学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=120, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Mon Mar 13 07:09:12 CST 2017, time=2017-03-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1282402, encodeId=527c12824028e, content=<a href='/topic/show?id=700239e0772' target=_blank style='color:#2F92EE;'>#呼吸道#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39707, encryptionId=700239e0772, topicName=呼吸道)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e94174, createdName=zhmscau, createdTime=Mon Mar 13 06:37:00 CST 2017, time=2017-03-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=179196, encodeId=a22a1e9196b3, content=然而，下呼吸道菌群在早期肺囊性纤维化发病机制中的作用仍然不确定。, beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM6DGOvNrRdcib3UmzMgpEQplCaQGBmjHytXQqvsuocO2uV2lOAaJibzDafJudKToVfU12LzwArHDb4TSrmU2hk5Qxzc6icoicBK3Dg/0, createdBy=a7901968505, createdName=明心见性, createdTime=Sat Mar 11 23:00:42 CST 2017, time=2017-03-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=179154, encodeId=91b31e91547b, content=囊性纤维化的婴幼儿中，下呼吸道感染和炎症与不良的呼吸结局有关。, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Pw2csslt7CukWiabqiblnQAXaDEiaxhu025c3P0XshccTrbvGWBjKvnHIxbK3vqa80P7WGIFuicCFet97TicrNKpgB3TdabxP1vMh/0, createdBy=28851960965, createdName=榄枷檬, createdTime=Sat Mar 11 17:02:07 CST 2017, time=2017-03-11, status=1, ipAttribution=)]
    2017-03-11 明心见性

    然而，下呼吸道菌群在早期肺囊性纤维化发病机制中的作用仍然不确定。

    0

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    2017-03-11 榄枷檬

    囊性纤维化的婴幼儿中，下呼吸道感染和炎症与不良的呼吸结局有关。

    0

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