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吉利德以49亿美元全现金收购Forth Seven公司,获得靶向CD47免疫检查点的癌症免疫疗法

2020-03-06 不详 MedSci原创

吉利德科学公司(Gilead Sciences)以每股95.50美元的价格,总价为49亿美元的全现金交易收购了Forth Seven公司来扩大其肿瘤学业务。Forth Seven公司专门研究针对CD47免疫检查点的癌症免疫疗法。

吉利德科学公司(Gilead Sciences)以每股95.50美元的价格,总价为49亿美元的全现金交易收购了Forth Seven公司来扩大其肿瘤学业务。Forth Seven公司专门研究针对CD47免疫检查点的癌症免疫疗法。

CD47是一种属于免疫球蛋白(Ig)超家族的细胞膜受体,它存在于许多肿瘤细胞的表面,并且通过向巨噬细胞发出"不要吃我"信号来防止被免疫系统所吞噬。

研究还表明,阻断CD47可使某些肿瘤细胞进入程序性细胞死亡(凋亡)状态。

Forth Seven公司是试图开发靶向CD47药物的生物技术公司之一,其创始人斯坦福大学研究员Irv Weissman是发现这种蛋白质作用的科学家之一。

在12月于美国ASH会议上报告的1b期研究中,Magrolimab(原Hu5F9-G4)在患者中,总缓解率达92%,在未经治疗的骨髓增生异常综合征(MDS)和急性髓细胞性白血病(AML)患者中完全缓解率为50%。

Forth Seven公司还在非霍奇金淋巴瘤、弥漫性大B细胞淋巴瘤和三种实体瘤(直肠癌卵巢癌和膀胱癌)患者中测试该药。

原始出处:


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    2020-11-06 lidong40
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    2020-07-22 sodoo
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