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Clin Gastroenterology Hepatology: 中性粒细胞与淋巴细胞比率与住院肝硬化患者的死亡率有关

2018-11-11 MedSci MedSci原创

中性粒细胞与淋巴细胞的比率(NLR)是肝硬化患者免疫失调的生物标志物,测量成本低廉。研究人员在本项研究中探究了NLR与住院肝硬化患者死亡率之间的关系。

背景与目的
中性粒细胞与淋巴细胞的比率(NLR)是肝硬化患者免疫失调的生物标志物,测量成本低廉。研究人员在本项研究中探究了NLR与住院肝硬化患者死亡率之间的关系。

方法
研究人员使用北美肝硬化住院患者的终末期肝病研究联盟的数据进行了一项回顾性研究,并收集了患者人口统计学数据,NLR,终末期肝脏模型的数据疾病(MELD)评分,血清Na水平,肝硬化阶段,感染,肝细胞癌和ACLF严重程度(基于器官衰竭的数量)。竞争风险回归分析评估出院后1年内的死亡率。

结果
入院时患者平均年龄为57岁,平均MELD评分为21,平均血清Na水平为134 mmol / L.68名患者无器官衰竭,36%的患者确诊或疑似感染。在单变量模型中,死亡风险与NLR增加相关,最高值为8([HR] = 1.14; 95%CI,1.07-1.20;P<.001)。NLR在多变量模型中仍然具有统计学意义,此外,NLR是出院后90天内指数住院时间和死亡率的统计学显着独立预测因子。

结论
在对肝硬化患者的回顾性分析中,研究人员发现NLR在非选择性住院治疗后1年内与患者死亡率相关。

原始出处:

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    2019-03-09 许安
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    2018-11-13 gwc384
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  8. [GetPortalCommentsPageByObjectIdResponse(id=1711718, encodeId=01691e11718d6, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Sun Aug 11 02:32:00 CST 2019, time=2019-08-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2072362, encodeId=090e20e23628d, content=<a href='/topic/show?id=9d4ee84647' target=_blank style='color:#2F92EE;'>#GAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7846, encryptionId=9d4ee84647, topicName=GAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2dd327, createdName=许安, createdTime=Sat Mar 09 19:32:00 CST 2019, time=2019-03-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2064544, encodeId=f7d82064544d9, content=<a href='/topic/show?id=94ffe853a7' target=_blank style='color:#2F92EE;'>#Gastroenterol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7853, encryptionId=94ffe853a7, topicName=Gastroenterol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bed488, createdName=jktdtl, createdTime=Thu Jun 13 00:32:00 CST 2019, time=2019-06-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1296685, encodeId=f583129668557, content=<a href='/topic/show?id=29c82219e47' target=_blank style='color:#2F92EE;'>#中性粒细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22197, encryptionId=29c82219e47, topicName=中性粒细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3883266, createdName=yykkxiaodou, createdTime=Tue Nov 13 12:32:00 CST 2018, time=2018-11-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1302202, encodeId=2ef913022029e, content=<a href='/topic/show?id=82a6659902c' target=_blank style='color:#2F92EE;'>#淋巴细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65990, encryptionId=82a6659902c, topicName=淋巴细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e34303, createdName=wetgdt, createdTime=Tue Nov 13 12:32:00 CST 2018, time=2018-11-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1427260, encodeId=fb07142e260ad, content=<a href='/topic/show?id=221d685172' target=_blank style='color:#2F92EE;'>#EPA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6851, encryptionId=221d685172, topicName=EPA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4a9b4077760, createdName=gwc384, createdTime=Tue Nov 13 12:32:00 CST 2018, time=2018-11-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1504527, encodeId=a62c150452efb, content=<a href='/topic/show?id=7730e85412' target=_blank style='color:#2F92EE;'>#Gastroenterology#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=122, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7854, encryptionId=7730e85412, topicName=Gastroenterology)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5fc29706655, createdName=chaojitidian, createdTime=Tue Nov 13 12:32:00 CST 2018, time=2018-11-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1046353, encodeId=dd1210463538c, content=谢谢!最新的信息读起来就是收获大, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=guging, createdTime=Mon Nov 12 00:32:00 CST 2018, time=2018-11-12, status=1, ipAttribution=)]
    2018-11-12 guging

    谢谢!最新的信息读起来就是收获大

    0

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