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癌症早筛技术迎来全新技术,莱盟君泰LAM助力精准医疗

2018-03-27 MedSci MedSci

2018年3月27日,专注于开发癌症早期筛查与临床干预前沿技术的莱盟君泰LAM今日宣布,目前该公司已为美国医生提供突破性癌症早期筛查IvyGene检测产品,该产品基于ctDNA甲基化液体活检技术,将在今年向公众全面推出。IvyGene检测是一项精准、无创血液检测,该产品通过检测血液样本中ctDNA的多个位点的甲基化模式,以确认恶性肿瘤的存在,并提供与肿瘤相关的实时信息。 顺应国家健康战略

2018年3月27日,专注于开发癌症早期筛查临床干预前沿技术的莱盟君泰LAM今日宣布,目前该公司已为美国医生提供突破性癌症早期筛查IvyGene检测产品,该产品基于ctDNA甲基化液体活检技术,将在今年向公众全面推出。IvyGene检测是一项精准、无创血液检测,该产品通过检测血液样本中ctDNA的多个位点的甲基化模式,以确认恶性肿瘤的存在,并提供与肿瘤相关的实时信息。

顺应国家健康战略,癌症早期筛查成为疾病预防重要手段

“目前关于癌症的统计数据令人震惊:42%的男性和38%的女性将会在他们一生中的某个时间节点被诊断出患有癌症。”莱盟君泰LAM董事长李戍博士表示。根据资料显示,癌症早期筛查的普及,使美国近二十年癌症总体死亡率下降25%。

据《2017中国城市癌症最新数据报告》显示,中国是癌症高发国家,每天约有一万人确诊癌症,平均每分钟就有7人。《国家癌症登记数据库报告》指出我国癌症死亡患者平均约有60%是本可以预防和避免的。去年政府十九大报告中提出,健康中国上升为国家战略,在疾病的诊治上,强调“坚持预防为主”。2018年政府工作报告中,全国政协委员王贵齐建议,对癌症发病高危人群,以及有明确证据证明通过筛查早诊早治,明显降低发病和死亡的高发癌症病种,国家将加大资金投入,在医保以及新农合中设立专项资金进行早期筛查,真正实现关口前移,预防为主。

ctDNA甲基化液体活检技术成为癌症早筛领域的发展方向

IvyGene检测所使用的ctDNA甲基化液体活检癌症早期筛查技术由中美顶尖科学家-UCSD人类基因组医学研究所所长张康教授和中山大学肿瘤防治中心徐瑞华教授团队联合完成,研究成果2017年10月发表于《自然》子刊,西京医院和华西医院也参与了研究。短短数月,该研究成果便已成功转化为产品,使公众能够通过该项服务切身体会到癌症早筛的益处,备受业界瞩目。

该项研究成果在《自然》子刊发表以后,不仅在美国引发关注,在国内也获得业内的高度重视。跟美国同步,在国内该项技术也成功转化为迈赛普TM检测产品。该产品是由LAM中国(北京莱盟君泰)基于临床3万例样本研究,针对中国市场推出的用于泛癌早期筛查的ctDNA甲基化液体活检产品,准确率高达85%,给癌症早期筛查带来了曙光。正是莱盟君泰LAM前期五十万级的临床样本库的积累,机器学习和医学大数据分析技术的发展,以及患癌高危人群对早期检测的大量需求,加速了ctDNA甲基化肿瘤早筛技术到产品的转化,可以说迈赛普TM所使用的ctDNA甲基化液体活检技术就是癌症早筛领域的新方向。


图:多种癌症的甲基化分析

癌症早筛产品迈赛普TM服务中国人群

与大多数通过研究DNA突变来确定患癌风险的基因检测不同,迈赛普TM通过实时监测ctDNA甲基化的变化来检测癌变的发生和发展。到目前为止,迈赛普TM甲基化液体活检技术已经可以有效识别多种恶性肿瘤,为患者选择有效的早期肿瘤治疗方案和提高生存预期,也为其他恶性肿瘤检测方法的建立提供了有力证据。迈赛普TM检测在今后将与包括乳房X光造影检查、PET扫描和活检在内的其他诊断检测结合使用。

“在癌症精准医疗这个领域中,莱盟君泰前瞻性的迈赛普TM癌症早期筛查无疑实现了一次重大变革。每天都有成千上万的人在与癌症作斗争,如何在早期便能确定癌症的存在和发展对每个患者的生存至关重要。”健康衰老及癌症综合治疗研究所创始人和高端医疗主任Mark Rosenberg博士补充道。此次莱盟君泰迈赛普TM的推出,标志着人类防治癌症进入了新的阶段,在将癌症从危害生命的疾病转变为可治可控的疾病道路上迈进了一步。

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    2018-05-24 lxg951
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    2018-03-29 nakerunner
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    2018-03-28 1e0f8808m18(暂无匿称)

    全新技术.学习了.

    0

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