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J Infect Dis:乙型肝炎硬化患者使用替诺福韦可降低肝细胞癌发病率

2018-12-19 MedSci MedSci原创

新型口服抗乙型肝炎病毒(HBV)药物替诺福韦地索普西(TDF)对亚洲人肝脏疾病的治疗效果的研究很有限,因此本项研究旨在探究TDF对亚洲慢性乙型肝炎(CHB)人群肝细胞癌(HCC)发病率的影响。

背景及目的:
新型口服抗乙型肝炎病毒(HBV)药物替诺福韦地索普西(TDF)对亚洲人肝脏疾病的治疗效果的研究很有限,因此本项研究旨在探究TDF对亚洲慢性乙型肝炎(CHB)人群肝细胞癌(HCC)发病率的影响。

方法
这是一项回顾性队列研究,研究人员对6914例慢性HBV感染且没有移植史的成年人进行了数据分析,其中774名接受TDF治疗,6140名未接受治疗的患者。在进行年龄,性别,HBV e抗原状态,HBV DNA水平,丙氨酸氨基转移酶(ALT)水平,基线肝硬化状态和随访时间的倾向评分匹配(PSM)后,共筛选出591个治疗患者和591个未经治疗的患者。Kaplan-Meier分析用于估计HCC的累积风险,Cox比例风险模型来估计组间的HCC风险。

结果
未治疗组的8年累积HCC发生率显着较高(20.13%VS4.69%; P <.0001)。肝硬化是HCC的重要预测因子([aHR],5.36; 95%[CI],2.73-10.51; P <.001)。根据年龄,性别,HBV DNA水平,ALT水平和研究部位调整的多变量分析,TDF可使患者HCC风险降低77%(aHR,0.23; 95%CI,.56-.92)。

结论
在患有CHB的肝硬化和非肝硬化亚洲患者中,TDF治疗与8年HCC累积发病率的降低显着相关。

原始出处:

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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=355894, encodeId=a5853558942d, content=谢谢了,学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=30331616752, createdName=txqjm, createdTime=Thu Dec 20 06:41:34 CST 2018, time=2018-12-20, status=1, ipAttribution=)]
    2019-12-04 xjy02
  8. [GetPortalCommentsPageByObjectIdResponse(id=1823516, encodeId=81de1823516e3, content=<a href='/topic/show?id=b2873e9220e' target=_blank style='color:#2F92EE;'>#发病率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37922, encryptionId=b2873e9220e, topicName=发病率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aa0e14, createdName=lifestar, createdTime=Sun Dec 30 12:57:00 CST 2018, time=2018-12-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1825683, encodeId=0483182568308, content=<a href='/topic/show?id=1a942339426' target=_blank style='color:#2F92EE;'>#乙型肝炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23394, encryptionId=1a942339426, topicName=乙型肝炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ea6321, 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=355894, encodeId=a5853558942d, content=谢谢了,学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=30331616752, createdName=txqjm, createdTime=Thu Dec 20 06:41:34 CST 2018, time=2018-12-20, status=1, ipAttribution=)]
  9. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=355894, encodeId=a5853558942d, content=谢谢了,学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=30331616752, createdName=txqjm, createdTime=Thu Dec 20 06:41:34 CST 2018, time=2018-12-20, status=1, ipAttribution=)]
    2018-12-20 清风拂面

    谢谢分享学习

    0

  10. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=355894, encodeId=a5853558942d, content=谢谢了,学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=30331616752, createdName=txqjm, createdTime=Thu Dec 20 06:41:34 CST 2018, time=2018-12-20, status=1, ipAttribution=)]
    2018-12-20 txqjm

    谢谢了,学习

    0

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