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Am J Trop Med Hyg:强力霉素可预防疟疾的同时降低国际旅行者流行性感冒病的风险

2020-02-19 不详 网络

旅行者通常同时面临类流感(ILI)和疟疾的风险。强力霉素对引起ILI的病原体具有活性,可用于预防疟疾。我们评估了ILI的危险因素,以及预防疟疾的选择是否与ILI有关。 TravMil是一项前瞻性观察研究,招募到军事旅行诊所就诊的受试者。流感样疾病的定义是主观发烧伴有喉咙痛或咳嗽。分析旅行的特征和预防疟疾的用途,以确定与ILI发生的关系。使用具有强大误差方差的Poisson回归模型用于估计ILI的相

旅行者通常同时面临类流感(ILI)和疟疾的风险。强力霉素对引起ILI的病原体具有活性,可用于预防疟疾。我们评估了ILI的危险因素,以及预防疟疾的选择是否与ILI有关。

TravMil是一项前瞻性观察研究,招募到军事旅行诊所就诊的受试者。流感样疾病的定义是主观发烧伴有喉咙痛或咳嗽。分析旅行的特征和预防疟疾的用途,以确定与ILI发生的关系。使用具有强大误差方差的Poisson回归模型用于估计ILI的相对风险(RR)。

总共登记了3,227次旅行:男性62.1%,中位年龄39岁(四分位间距[IQR] 27,59),平均旅行时间19天(IQR 12,49);32%的人去了非洲,40%的人去了亚洲,27%的人去了加勒比和拉丁美洲。出行最常见的原因是军事旅行(46%)和度假(40%)。其中,有20%服用了强力霉素,有50%采取了其他预防措施,有30%没有服用。

结果,8.7%的人发展了ILI ILI的RR降低与强力霉素(RR 0.65 [0.43-0.99],P = 0.046)和军事旅行有关(RR 0.30 [0.21-0.43],P <0.01)。女性患ILI的风险增加(RR 1.57 [1.24-1.98],P <0.01),前往亚洲旅行(RR 1.37 [1.08-1.75],P = 0.01)和乘船旅行(RR 2.21 [1.73-2.83],P <0.01)。

综上所述,该研究结果表明,使用强力霉素预防疟疾可降低ILI风险。可能的原因包括抗炎或抗菌作用或其他无法衡量的因素。由于很少有减少旅行者ILI的策略,这些发现有待进一步研究。

原始出处:

Lago K, Telu K, et al., Impact of Doxycycline as Malaria Prophylaxis on Risk of Influenza-Like Illness among International Travelers. Am J Trop Med Hyg. 2020 Feb 10. doi: 10.4269/ajtmh.19-0648. 

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    2020-08-28 tulenzi
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