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Hypertension:早产年轻人肾脏大小、肾功能、血管紧张素和血压分析

2018-08-13 xing.T MedSci原创

由此可见,与足月产成人相比,早产的青年人肾脏较小,尿白蛋白与肌酐比值较高,血压和循环Ang I水平也较高。肾脏较小的早产成人具有较高的血压。

早产会导致成人包括高血压在内的血管疾病风险增加。由于早产可能影响肾脏发育,近日,血管权威杂志Hypertension上发表了一篇研究文章,该研究的主要目的是评估早产与足月产成人的肾脏大小和功能,并评估它们与血压(BP; 24小时动态血压监测)和循环肾素-血管紧张素系统的关系。该研究纳入了92名出生(1987-1997)早产(≤29周妊娠)和年龄、性别和种族匹配的出生足月(n=92)的年轻人。

早产的青年人肾脏较小(80±17 vs. 90±18cm3/m2; P<0.001),尿白蛋白与肌酐比值较高(0.70;四分位数范围为0.47-1.14 vs. 0.58;四分位数范围为0.42-0.78 mg/mmol,P=0.007),24小时收缩压(121±9 vs. 116±8 mmHg; P=0.001)和舒张压(69±5 vs. 66±6mmHg; P=0.004)较高,但估计的肾小球滤过率相似。血压与早产儿的肾脏大小呈负相关。血浆Ang I在早产成人中较高,相比于足月产参与者(36.3;四分位数范围为13.2-62.3 vs. 19.4;四分位数范围为9.9-28.1pg/mL; P<0.001)。肾素、Ang II、Ang(1-7)和alamandine水平没有组间差异。在早产组,而不是足月产组中,较高的血压与较高的肾素和alamandine水平显著相关,较低的出生体重和孕龄与较小的成年肾大小显著相关。

由此可见,与足月产成人相比,早产的青年人肾脏较小,尿白蛋白与肌酐比值较高,血压和循环Ang I水平也较高。肾脏较小的早产成人具有较高的血压。

原始出处:

Katryn Paquette,et al. Kidney Size, Renal Function, Ang (Angiotensin) Peptides, and Blood Pressure in Young Adults Born Preterm The HAPI Study.Hypertension.2018. https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.118.11397

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    2019-01-24 yese
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    2019-01-10 feather89
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    2018-08-15 jyzxjiangqin

    早产年轻人肾脏大小。

    0

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    2018-08-14 liumin1987

    早产年轻人的肾脏特点。

    0

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    2018-08-14 太阳系小猪

    早产的人肾脏小?肾脏小的容易得高血压?还能这样吗?

    0

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J Rheumatol:系统性红斑狼疮女性患者的孕前心血管健康和妊娠结局

差/中等的孕前心血管健康影响SLE女性患者早产和SGA婴儿的妊娠结局。

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