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FEBS Lett:铜绿假单胞菌鼠李糖脂与帕金森病相关蛋白α-突触核蛋白之间的关系

2018-04-01 MedSci MedSci原创

帕金森病相关蛋白α-突触核蛋白(αSN)是一种天然的非折叠蛋白,但其结构可以通过膜和表面活性剂来调节。机会性病原体铜绿假单胞菌(PA)产生并分泌调节细菌生物膜的生物表面活性剂鼠李糖脂(RL)。 本研究中,研究人员发现单体RL增强了αSN透化膜的能力,而胶束RL迅速诱导具有蠕虫状原纤维外观的蛋白质β-折叠结构,这种结构不能接种无RL的神经元,而是比αSN原纤化更快地转变成线性原纤维。暴露于αSN会降

帕金森病相关蛋白α-突触核蛋白(αSN)是一种天然的非折叠蛋白,但其结构可以通过膜和表面活性剂来调节。机会性病原体铜绿假单胞菌(PA)产生并分泌调节细菌生物膜的生物表面活性剂鼠李糖脂(RL)。

本研究中,研究人员发现单体RL增强了αSN透化膜的能力,而胶束RL迅速诱导具有蠕虫状原纤维外观的蛋白质β-折叠结构,这种结构不能接种无RL的神经元,而是比αSN原纤化更快地转变成线性原纤维。暴露于αSN会降低PA的生物膜形成程度,除非RL存在。

该研究结果表明,RL与αSN的相互作用可能影响αSN聚集和细胞毒性,可能牵涉微生物代谢物在帕金森病的发生和进展中。

原始出处:


Andersen KK, Vad BS, et al., Pseudomonas aeruginosa rhamnolipid induces fibrillation of human α-synuclein and modulates its effect on biofilm formation. FEBS Lett. 2018 Mar 23. doi: 1 0.1002/1873-3468.13038.  

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    2018-04-03 三生有幸9135

    学习一下谢谢分享

    0

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    2018-04-01 清风拂面

    谢谢分享学习

    0

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