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2022年1月30日简报:灭活疫苗加强针可防奥密克戎致重症;欧盟全面推行防疫解封政策;奥密克戎感染病例占单周新冠病例总数的99.9%;

2022-01-30 MedSci整理 MedSci整理

截至北京时间2022年1月30日7时01分,Worldometers世界实时统计数据显示,全球累计确诊新冠肺炎(COVID-19)病例超过3亿7289万例,新增2,628,337例,达到372,899

截至北京时间2022年1月30日7时01分,Worldometers世界实时统计数据显示,全球累计确诊新冠肺炎COVID-19)病例超过3亿7289万例,新增2,628,337例,达到372,899,245例。累计死亡病例567.5万例,达到5,675,389例。新增死亡为7,647例。康复为294,483,568例,重症和危重症病人达到94,660例;全球新冠确诊病例超过100万例的国家达49个,120个国家病例超10万例。昨日报道:2022年1月29日简报:奥密克戎“姐妹株”BA.2传染性翻倍,可能很快成为主流;纽约住院病例大降47%

美疾控中心:奥密克戎感染病例占单周新冠病例总数的99.9%

美国疾病控制和预防中心网站28日公布的每周疫情报告称,疫情模型数据显示,截至1月22日的一周,变异新冠病毒奥密克戎毒株感染病例占全美新冠确诊病例总数的99.9%,德尔塔毒株感染病例仅占总数的0.1%。

美国于去年12月1日报告首例奥密克戎毒株感染病例, 此后该毒株感染病例持续激增。数据显示,截至去年12月4日的一周,奥密克戎毒株感染病例占确诊病例总数的比例仅为0.6%;截至12月18日的一周,奥密克戎毒株感染病例数占比升至37.8%;截至12月25日的一周,这一比例升至74.1%;而截至今年1月15日的一周,这一比例已升至99.4%。

美疾控中心网站数据显示,全美27日新增新冠确诊病例572524例,目前全美7日平均日增新冠确诊病例数约57.7万例。全美27日新增新冠死亡病例达2625例,目前全美7日平均日增新冠死亡病例数为2300例,这是自去年2月中旬以来的新高。

日本新增确诊病例84933例 东京居家治疗人数达到6.4万

据日本放送协会(NHK)消息,截至到当地时间1月29日23时59分,日本报告新增新冠肺炎确诊病例84933例,较前一日又增加了3000多例,已连续五天刷新疫情暴发以来的最高纪录;新增相关死亡病例39例。

疫情在东京迅速蔓延,东京在过去24小时新增17433例确诊病例,与上周六同一时间相比,增加了1.6倍。居家就医的人数较前一日增加了3000多人,达到约6.4万。东京医院的病床使用率为48%。

美国新增超31万例确诊病例 专家称奥密克戎将致超100万美国人死亡

根据Worldometer实时统计数据,截至北京时间2022年1月30日6时30分左右,美国累计确诊新冠肺炎病例75408041例,累计死亡病例906550例。与前一日6时30分数据相比,美国新增确诊病例313382例,新增死亡病例1699例。

据《美国新闻与世界报道》网站28日报道,新冠变异毒株奥密克戎当前正席卷美国各地,导致死亡人数不断攀升。有专家预测指出,该病毒将导致美国超过100万人死亡。

欧洲60%人口将感染新冠,欧盟逆势推行防疫解封政策

据报道,欧盟理事会于近日发布欧盟内旅行的最新规定:游客只需携带疫苗接种证明或康复证明或阴性检测证明即可在欧盟27个国家之间畅行无阻,无需隔离或额外做新冠病毒检测。新规定将于2月1日生效。世界卫生组织此前表示,到3月,可能有60%的欧洲人感染奥密克戎。尽管整个欧洲的感染率很高,但各成员国相继响应,正摩拳擦掌等待解封日来临。

英国新增超7.2万例确诊病例 政府全面放开新冠防控惹争议

据英国卫生部1月29日公布的最新数据,过去24小时,英国新增新冠肺炎确诊病例72727例,累计确诊16406123例;新增死亡病例296例,累计死亡病例155613例。

英国政府为应对变异新冠病毒奥密克戎毒株启动的《应对新冠疫情:秋冬计划》B计划日前已全部结束。从27日起,英格兰民众无需戴口罩,无需在公共场所和活动中出示疫苗通行证。苏格兰、威尔士和北爱尔兰的疫情防控措施也有所放宽。

对英国政府取消B计划的决定,不少科研人员发出质疑。英国医师协会公共卫生医学委员会前主席、传染病学专家彼得·英格利希博士指出,奥密克戎毒株感染病例数仍然很高,新冠病毒并未消失,并仍将继续变异,“我们距离大流行结束还有很长的路要走”。英国沃里克大学病毒学教授劳伦斯·扬说:“面对极高的感染水平,取消B计划是一种风险,谈论结束大流行还为时过早。”

法国新增超33万例确诊病例 累计确诊逾1880万例

当地时间1月29日,法国公共卫生部门公布的数据显示,截至当天下午,法国累计新冠肺炎确诊病例18808595例,24小时新增332398例;累计报告死亡病例130457例,24小时新增178例;现存重症住院病例3634例。

意大利新增超13万例确诊病例 累计确诊逾1082万例

当地时间1月29日,意大利卫生部公布的最新统计数据显示,过去24小时,该国新增新冠肺炎确诊病例137147例,累计确诊10821375例;新增死亡病例377例,累计死亡145914例。

俄罗斯单日新增确诊病例首超10万例 累计确诊逾1161万例

据俄罗斯防疫指挥部29日消息,俄单日新增确诊病例首次超过10万例,创疫情暴发以来新高。

俄防疫指挥部当天数据显示,俄新增确诊病例较此前一天增加15.38%,达113122例,累计确诊11615779例;单日新增死亡病例668例,累计死亡330111例。俄首都莫斯科依然是全国疫情最严重的地区,单日新增确诊达26488例。

中科院最新研究:灭活疫苗加强针可防奥密克戎致重症

1月28日,中国科学院生物物理研究所王祥喜等在《自然》上刊登了一篇关于灭活疫苗加强针后免疫机制的论文,“Memory B cell repertoire from triple vaccinees against diverse SARS-CoV-2 variants”。研究者采集了60名接种过两剂次(0、1月程序)和60名接种过三剂次(0、1、7月程序)灭活疫苗志愿者的血清,通过新冠活病毒中和实验评估其对原始毒株和奥密克戎变异株的中和效价。

结果显示,接种两剂和三剂新冠灭活疫苗志愿者,针对奥密克戎中和抗体的血清转换率分别为3.3% (2/60) 和95% (57/60),表明灭活疫苗加强针接种有助于提升血清中的存量中和抗体。不过,接种三剂次新冠灭活疫苗志愿者血样中,奥密克戎中和抗体几何平均滴度为15.4,与原始株中和抗体几何平均滴度254相比,降低了16.5倍。但是,这一水平(15.4)仍然比接种两剂灭活疫苗产生针对德尔塔突变株的中和抗体水平要高。

他们研究还发现,结合RBD区域的抗体中,有31株能够强效中和野生型及所有关切变异株的假病毒和真病毒,半抑制浓度IC50在0.002至0.800μg/ml之间。其中30株抗体能够直接阻断RBD与ACE2的结合。

研究中分离出的31株广谱强效抗体中,有13株抗体对奥密克戎的IC50小于0.02ug/ml,是葛兰素史克与Vir生物技术公司(GSK/Vir)的VIR-7831和国内丹序生物尚处于临床试验阶段的DXP-604中和活性的10-40倍。

图片

在智利、巴西等国家真实世界数据表明,前期两剂次灭活疫苗产生针对德尔塔中和抗体几何平均滴度为6~10,但对预防德尔塔感染临床中重症的保护效率仍为80%以上。因此,推测三剂次灭活疫苗对奥密克戎感染临床中重症的保护可能仍然有效。现有疫苗接种后,血清存量中和抗体的水平不足以充分遏制突破性感染,那为什么还能有效提供重症保护呢?

研究者通过研究数据找到了答案。该研究从多名三剂新冠疫苗接种者的新冠特异性记忆B淋巴细胞中成功获得323株全人源抗体,其中24株对奥密克戎等突变株均有出色抑制活性,IC50(半数抑制浓度)均小于0.1微克/毫升(μg/mL)。这表明三剂次疫苗免疫后,约7%的记忆B淋巴细胞携有广谱性中和抗体,当人体被奥密克戎突变株感染时,这部分记忆B细胞会被特异性激活并增殖,产生大量能分泌高效中和抗体的浆细胞,从而实现对奥密克戎突变株的重症保护。

研究者认为,灭活疫苗加强针接种将有助于提升对奥密克戎突变株感染的重症保护。目前,相关数据也已提前上报国家药监局和世界卫生组织,为中国及全球新冠疫情防控公共策略的制定提供科学依据。

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    2022-01-30 1351f98dbdm

    世界都开放了,还要动态清零吗?

    0

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    2022-02-01 bioon3
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    2022-02-01 xugc
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    2022-01-30 小小医者

    要敢于面对病毒。邻居越南全面解封

    0

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