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J Invest Derm:非甾体类抗炎药(NSAIDs)可能预防皮肤癌

2014-12-20 MedSci MedSci原创译

据一项最新研究表明非甾体类抗炎药(NSAIDs)能够预防皮肤癌,该研究发表于近日的Journal of Investigative Dermatology上。NSAID可以降低大肠癌、肺癌、乳腺癌和前列腺癌的发病风险,但是还没有证据表明它能够预防皮肤癌。Chiho Muranushi及其同事根据已发表的文献进行了meta分析,研究了阿司匹林、非阿司匹林类NSAIDs以及其他NSAIDs类药物对鳞状

据一项最新研究表明非甾体类抗炎药(NSAIDs)能够预防皮肤癌,该研究发表于近日的Journal of Investigative Dermatology上。NSAID可以降低大肠癌、肺癌、乳腺癌和前列腺癌的发病风险,但是还没有证据表明它能够预防皮肤癌。Chiho Muranushi及其同事根据已发表的文献进行了meta分析,研究了阿司匹林、非阿司匹林类NSAIDs以及其他NSAIDs类药物对鳞状细胞癌(SCC)的预防作用。肤色浅的人种容易患SCC。NSAIDs可以抑制COX-2,而COX-2催化炎症因子前列腺素E2的合成。在长期紫外线的照射下,COX-2可以在SCC患者中过表达。研究者纳入了9篇文献,其中5篇是病例对照,3篇队列研究,以及一篇随机对照研究。meta分析结果表明,与不使用NSAIDs类药物的人相比,使用非阿司匹林类NSAIDs和其他类型NSAIDs的人其SCC发病率低。尤其是对于有过光化性皮肤肿瘤病史或角化细胞肿瘤的患者,NSAIDs的作用更为显著。使用阿司匹林的人其SCC的患病风险下降,但是数据结果不显著。只有随机对照实验表明阿司匹林的作用呈剂量依赖性。研究者认为,非

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    2015-06-20 d830372
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    2015-07-22 wjywjy
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    2014-12-22 cooco
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    2014-12-22 amyloid

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